Objective To evaluate the effect and toxicity of docetaxel combined with oxaliplatin,leucovorin and 5-fluorouracil regimen for patients with advanced gastric cancer,and compare with non-docetaxel chemotherapy regimen.Methods 130 patients with advanced gastric cancer were randomly divided into treatment group 87 patients and control group 43 patients.The regimen of the treatment groups was docetoxel 50mg/m2,iv infusion from day 1 to 3 ;oxaliplatin 65mg/m2,iv infusion on day 1 ;leucovofin 300mg/m2,iv infusion for 2 hours followed by 5-fluorouracil 500mg/m2,iv infusion from day 1 to 5.The regimen of the control group was oxaliplatin 130mg/m2,iv infusion on day 1.The usage of leucovorin and 5-fluorouracil were similar to the treatment group.All patients were evaluated after 2cycles( every cycle lasted 3 weeks).Results The effective rate in treatment group and in control group had statistical significance(P ＜ 0.05).The main to:deities were no statistical difference in two groups( P ＞ 0.05).Conclusion Docetoxel combined with oxaliplatin,leueovorin and 5-fluorouracil regimen is safe,high response and well tolerable for advanced gastric cancer.

Objective To investigate the short term efficacy of transcatheter arterial chemoembolization(TA-CE)combined with arsenic trioxide(AS203) in the treatment of primary liver cancer.Methods 91 patients with advanced primary liver cancer underwent routine hepatic arterial chemoembolization,repeated every 4 weeks for 2 to 3 cycles.In each cycle of chemoembolization,AS2O3 ,was injected intravenously once a day for 2 weeks at a dose of 10～15mg.Results All patients completed 2～3 cycles treatment and followed for more than one year.Total response rate was 61.7% and clinical benefit rate was 42 cases of partial response(PR) ,35 cases of no changes(NC) and 11 cases of progressive disease(PD).Quality of life improved in 61 cases and stabilized in 24 cases.Toxicifies was mild and tolerable.Conclusion TACE combined with arsenic trioxide in the treatment of primary liver cancer is efficient with a mild toxicities.

Objective To observe the therapeutic effect of reformed subhibernation therapy on status epilepticus in patients with severe viral encephalitis.Methods 96 children with severe viral encephalitis complicated by status epilepticus were randomly divied into control group and experimental group.Control group: routine treatment was given that includes anticonvulsivus,ice compress and conventional therapy.The anticonvulsivus was applied in five drugs: the same doses of wintermin and phenergan mixed up,10% chlorpromazine hydrochloride,luminal,valii,the drugs were delivered when convulsion occurred otherwise not.Experimental group: in addition to routine treatment reformed subhibernation therapy was given.The anticonvulsivus drug's was delivered in return each 4-6 h according to the drugs half life.And anticonvulsivus drugs were applied for 2 d then gotten off.The clinical manifestation,auxiliary examination and therapeutic efficacy of patients in two groups were observed.Results All of 96 cases were analyzed.The lotal effective rate in experimental group is higher than that in control group(?2=5.872,P