Professor LIU Yan-chi is a well-known Chinese medicine experts at home and abroad,came from family medicine,is the country,s third and fourth groups academic heir tutors of the old Chinese teacher academic experience,full of rich academic experience.This paper introduces the Professor LIU diseases for urban residents to make good use Ziyin academic thinking,followed by the introduction of its common Ziyin drugs(Deodeok,Ophiopogon japonicus,Dendrobium).Finally,through listing,Professor LIU treating habitual constipation with producing Jin and clearing away heat,treating Parkinson,s disease with nouringing yin and calming endopathic wind and removing heat,summarized in flexible mode of thinking and bring us enlightenment.

Objective Through testing the immune functions of SD rats in spring and autumn, the internal mechanisms that lung corresponding with the autumn of TCM were explored, in order to provide the experimental evidence for the pathological and physiological mechanisms of respiratory system seasonal diseases. Method The pineal extirpating rat model was employed, and the indexes of spleen and thymus gland and the phagocytosis function of alveolar macrophage were observed at vernal equinox and autumnal equinox respectively. Result The indexes of spleen and thymus in the normal group and the false operation group at autumnal equinox were significantly lower than those at vernal equinox (P

Objective:To investigate the effects of Qingxin Yangshen Chinese herbs on ?-adrenoceptor in cardiocytes of stress rats.Methods:Adopting the method of radoligand binding,the affinity of ?-adrenoceptor of experimental myocardium cells and density were analyzed.Meanwhile,RT-PCR was used to test mRNA of ?-adrenoceptor of myocardium cells.To observe the effect of Qingxin Yangshen Fang on ?-adrenoceptor of myocardium cells of stress rats,and the Zhusha Anshen Pills and Propranololas the control groups.Results:All the three groups above can increase the affinity of ?-adrenoceptor of experimental myocardium cells,promote its sensitivity and notably inhibit the decrease of density of receptors and control down-regulation of expression of ?1-ARmRNA induced by stress,and regulate up the expression of ?2-ARmRNA.Conclusion:The Chinese herbs of Qingxin Yangshen had the effect of acceptor inhibiting and can regulate the changes of ?-adrenoceptor of myocardium cells induced by stress.

After analyzing current different understandings on the theory of spleen taking charge of energy of long summer, the author put forward the essential connotation that the spleen is a self-balanced regulation system based on time, and the spleen mainly regulates the body in long summer. The spleen is exteriorly-interiorly related to the stomach. The spleen governs ascending and the stomach governs descending, which actually summarizes the function of the whole digestive system. The spleen and stomach co-keep the self-balanced condition for the body, through the coordination of receiving and transportation, ascending and descending, dryness and dampness. The spleen is respon-sible for transportation and transformation, ascending of the clear, with a preference for dryness and aversion to dampness, which is regarded as Taiyin wet earth, corresponding with dampness in the long summer. The stomach governs receiving and descending, with a preference for moistness and aversion to dryness, which is considered to be the Y angming dry earth. In the long summer, spleen deficiency due to dampness retention may lead to hypo-func-tions of transporting and transforming, ascending of the clear; stomach excess thanks to the help of moistness and heat may lead to relative hyper-functions of receiving and decomposing food, as well as descending. The functional condition of spleen deficiency and stomach excess duo to abundant dampness in the long summer plays a dominant role in regulation on their own system and other four zang-organs; in other seasons, the functions of spleen and stomach are in a subordinate state assisting or inhibiting other four zang-organs, in pace with time, to keep balanced condition for the body, through their characteristics of nourishing and transforming. Due to spleen deficiency and stomach excess in the long summer, manifestations of the body are hyper-function of digestion and hypo-function of absorption, and may easily lead to problems in the digestive system, such as abdominal distension and loose stool. Correct understanding on the essential connotation of spleen taking charge of energy of long summer has an impor-tant significance on the pathology, diagnosis, prevention, healthcare and treatment of seasonal attacks in the digestive system.

By reviewing its experimental studies as well as clinical investigations,experiences and proven cases,this paper presented the main directions and methods in the study of Guo-Min (GM) decoction.It proved that GM decoction had identified anti-inflammatory and anti-allergic effects.Its effect may be through blocking H1 receptors,and lowering IgE in serum of type I allergic reaction to achieve.It showed that the clinical observation on multi-center,large sample randomized double-blinded controlled trials combined with compatibility laws of Chinese herbs and prescriptions by chemomics will be the future study direction of GM decoction.It played significant role in the prevention and treatment of allergic diseases.

Objective:To explore the difference in susceptibility to high-fat diet induced obesity in rats,as well as the changes of serum proteins. Method:Forty male SD rats were divided into basic group and high-fat diet group randomly. After 5w feeding DIO(diet-induced obesity)and DIO-R(diet-induced obesity resistance) rats were selected according to their body weight gain. The rats were sacrificed and the changes of serum proteins were screened using WCX2 proteomic chips made by American Ciphergen Biosystems. Results: DIO rats were significantly different from DIO-R rats in body weight,body-fat ratio,blood glucose and blood lipids. At the molecular weight range between 2 to 100 ku,the proteins with molecular weight of 7 945 and 9 513 were significantly expressed differently between DIO and DIO-R rats,and the proteins with molecular weight of 4496, 6152, 6267 were significantly expressed differently between DIO-R and control rats (the rats were fed basic diet). Conclusion:Different susceptibility to DIO or DIO-R was found in SD rats when they were fed high-fat diet. The differentially expressed serum proteins between DIO rats and DIO-R were observed,which might provide the basis for further isolation,purification and identification of these proteins.

This study was aimed to explore the influence of extreme environment changes on the lung immune function in rats. Artificial climate system was used to simulate six extreme weathers, which were the sudden temperature increase (ZS), sudden temperature drop (ZJ), continuous high temperature (CG), continuous low temperature (CD), high temperature and high humidity (GWGS), normal temperature and high humidity (CWGS). And then, the method of enzyme-linked immunosorbent assay (ELISA) was adopted to detect bronchoalveolar lavage fluid (BALF) and related immune substances in lung tissues. The results showed there was significant difference of ZJ on IL-10 (P<0.05). There were significant differences of CG, CD, GWGS, and CWGS on IL-6, INF-γ and sIgA (P<0.05). Contents of the GWGS group and CWGS group were higher than that of the CG group and CD group. There was very significant difference on IL-10 in the CD group (P<0.01). It was concluded that the extreme environment changes had different influence on body’s immune. And different intervention factors cause the body’s immune factors to response accordingly.

This paper systematically analyzed the understanding of qi from the perspectives of matter， energy， information and relationship reality， introduced the original holistic principle of systematic traditional Chinese medicine （TCM）， and considered the latest research results of qi （three-layer material theory）， trying to optimize the structure framework of the qi theoretical system and exhibit the occurrence and development rules of original qi. It emphasizes the hierarchical order of qi transformation following the original holistic principle， and takes this to guide the clinical understanding of “qi diseases”， helping doctors grasp the basic pathogenesis of the disease， that is abnormal qi movement， and helping them establish the awareness of providing systematic TCM treatment to patients by taking qi regulation as the key. At the same time， it discusses people within the structure of time and space， and points out that the treatment of diseases must comply with the principle of “the harmony of heaven， earth， and human beings”.

There are different views on the theory of “spleen governs time”， which is still a hot spot in the study of Zangxiang （藏象） theory. Based on Zangxiang time-space view， it is found that the thinking mode of the spleen governing time theory follows space-time logic. It is believed that the different time views of the spleen governing time are all formed based on the space view that the spleen belongs to earth and resides in the center， and the zang time theory is developed with the unified time and space logic. Guided by Zangxiang time-space view， the origin of the spleen belonging to earth and residing in the center is traced， and the theoretical connotation and its clinical application of spleen governing time under different time-space logic are explored with reference to the four season and five zang theory， five season and five zang theory， six season and six zang theory， and eight season and eight zang theory.

Long non-coding RNA (lncRNA) refers to non-coding RNA longer than 200 nt, with one or more short open reading frames (sORF), which encode functional micro-peptides. These functional micro-peptides often play key roles in various biological processes, such as Ca²⁺ transport, mitochondrial metabolism, myocyte fusion, cellular senescence and others. At the same time, these biological processes play a key role in the regulation of body homeostasis, diseases and cancers development and progression, embryonic development and other important physiological processes. Therefore, studying the potential regulatory mechanisms of micro-peptides encoded by lncRNA in organisms will help to further elucidate the potential regulatory processes in organisms. Furthermore, it will provide a new theoretical basis for the subsequent targeted treatment of diseases and improvement of animal growth performance. This review summarizes the latest research progress in the field of lncRNA-encoded micro-peptides, as well as the progress in the fields of muscle physiological regulation, inflammation and immunity, common human cancers, and embryonic development. Finally, the challenges of lncRNA-encoded micro-peptides are briefly described, with the aim to facilitate subsequent in-depth research on micro-peptides.
Animals ; Humans ; Neoplasms/therapy* ; Open Reading Frames ; Peptides/chemistry* ; RNA, Long Noncoding/genetics*