The performance appraisal system of medical institutions serves as the cornerstone for hospital management. Thanks to the grow-th of information technology, information platform has grown into an indispensable tool for performance appraisal in hospitals as well. This paper focuses on the design and application of such a platform for performance appraisal, as well as the innovations on the appraisal contents and forms, setup and control methods for appraisal indicators, and the achievements made with such a platform.

Abstract: Objective　To compare and analyze the clinical characteristics, diagnosis, and treatment of different subtypes of severe influenza in neonates to provide a reference for the diagnosis and treatment of neonatal severe influenza. Methods A cohort of 40 neonates with severe influenza who were hospitalized in the neonatology ward of Children's Hospital Affiliated to Zhengzhou University between January 2019 to December 2023 were selected and divided into two groups based on the virus subtype: influenza A (n=23) and influenza B (n=17). A retrospective analysis was conducted to compare general information, clinical manifestations, auxiliary examinations, complications, and treatment outcomes of neonates with severe influenza A and B infection. Results The number of days of hospitalization was longer in cases of influenza A than that of influenza B. The proportion of neonates with severe influenza A who exhibited fever was higher than that for influenza B, and a higher percentage of those with fever had peak temperatures ranging from 38.1 ℃ to 39 ℃. Gastrointestinal symptoms, including vomiting and diarrhea leading to dehydration, were more evident in severe influenza B cases. The proportion of influenza A cases with abnormal creatine kinase-MB isoenzyme levels (>25 U/L) was higher than that of influenza B, and the differences were statistically significant (P<0.05). There were no significant differences between the two types of influenza in other clinical manifestations, the incidence of pneumonia/respiratory failure complications, peripheral blood leukocyte count and classifications, the proportion of abnormal aspartate aminotransferase (AST) (>40 U/L), alanine aminotransferase (ALT) (>40 U/L), and creatine kinase (CK) (>200 U/L), and lactate dehydrogenase (LDH) values (all P>0.05). In terms of treatment, neonates treated with Oseltamivir within 48 hours of onset mainly suffered from influenza A. Among those treated with Oseltamivir, the proportion of influenza A cases whose body temperature returned to normal within 24 hours was relatively higher, whereas, for those whose temperature returned to normal within 24-72 hours, the proportion was relatively higher in influenza B cases. These differences were statistically significant (all P<0.05). Conclusions Severe neonatal influenza usually occurs in winter and spring. After severe infection, fever is more obvious in neonates with influenza A, which is more likely to cause myocardial cell damage. Neonates with influenza A can be treated with Oseltamivir earlier and return to normal body temperature faster than those with influenza B after Oseltamivir treatment. Gastrointestinal symptoms are more common in neonates with severe influenza B.

OBJECTIVE To investigate the bone development activity and differences in safety of ethanol extract (EE) and water decoction (WD) of Psoralea corylifolia L.efficiently.METHODS Zebrafish larvae were co-exposed to prednisolone 25 μmol· L-1 and different concentrations of EE and WD (0.1,1.0,10 and 100 mg crude drug· L-1),and etidronate disodium (ED) 30 mg·L-1.All these groups were incubated at 28.5℃ until 9 dpf.The medium solution was changed every other day.Zebrafish skeleton at 9 dpf was stained with alizarin red and inspected under an optical microscope,in addition,the death toll and organ toxicity of zebrafish were also observed.The mRNA expression of osteoprotegrin (OPG) and receptor activator of NF-κB ligand (RANKL) in 9 dpf zebrafish were determined with fluorescence quantitative PCR.Zebrafish embryos (1 dpf) were exposed to various concentrations of EE (10,20,30,35,40,50 and 60 mg crude drug· L-1),WD (10,50,100,125,150,175,200 and 500 mg crude drug· L-1),psoralen (12.5,25.0,50.0,100.0,200.0 and 400.0 μmol·L-1) and bakuchiol (1,5,10,25 and 50 μmol· L-1).Embryonic morphology of zebrafish (3 dpf) was inspected with an optical microscope and the death toll of embryos or larvale was counted from 2 dpf to 9 dpf and LC50was calculated.Components of EE and WD ware analyzed by HPLC method.RESULTS Both EE (0.1 mg crude drug· L-1) and WD (1.0 mg crude drug· L-1) groups could increase the staining area and optical density values of zebrafish skeleton compared with prednisolone group (P＜0.01),indicating the increase in bone mineralization;the OPG mRNA expression in both EE and WD (1.0 mg crude drug· L-1) groups increased,while the RANKL mRNA expression decreased (P＜0.01) and the ratio of OPG/RANKL improved obviously (P＜0.01).Embryos exposed to EE,WD,psoralen and bakuchiol showed swelling of the heart and yalk sac,and decrease in GOT.The LC50 of WD and psoralen was 5～8 and 5～21 times that EE and bakuchiol,respectively.The composition and relative content of EE and WD also varied considerably.CONCLUSION Bone development activity and toxicity of EE are both stronger than those of WD.The lipid soluble characteristic components of Psoralea corylifolia L.,may be critical components of toxicity.

Objective To investigate the correlation between family cohesion and adaptability and quality of life in patients with enterostomy. Methods Using Chinese version of Family Adaptability and Cohesion Scale (FACESⅡ-CV) and Chinese version of Stoma-Quality of Life (STOMA-QOL-C) to investigate the status of family cohesion and adaptability, family type and their impact on quality of life of 110 patients with enterostomy. Results Scores of family cohesion and adaptability averaged 59.15 ± 11.94, 47.32 ± 9.40,were significantly lower than 63.90 ± 8.00 and 50.90 ± 6.20 in the norm,and the difference was statistically significant (t=-4.171,-3.990, P<0.01).The family cohesion was positively correlated with the score of quality of life, social interaction and psychological burden(r=0.274, 0.284, 0.263, P<0.05), and the family adaptability was positively correlated with the score of quality of life,social interaction and psychological burden(r=0.316, 0.338, 0.228, P<0.05 or 0.01). The balance type family was 30 cases;scores of quality of life averaged 45.10±7.26, the intermediate type family was 50 cases;scores of quality of life averaged 43.48±9.98, the extreme type family was 28 cases;scores of quality of life averaged 43.37 ± 16.68, and difference between the three was no statistically significant(F=0.442, P=0.665). Conclusions In the nursing process of patients with enterostomy, health care workers should pay attention to improve family cohesion and adaptability, as to achieve the purpose of improving the quality of life of the patients.

T lymphocyte subpopulation and level of soluble interleuckin 2 receptor in peripheral bloodand serum of primary hepatocellular carcinoma and donor were tested.The results show that de-crease of T lymphocyte subpopulations is related with increase of level of soluble interleuckin2 re-ceptor in patients with primary hepatocellular carcinoma.

The sense of stigma is common in young and middle-aged diabetic patients, which greatly affects their quality of life. This article reviews the concepts related to stigma, the current status of stigma in young and middle-aged diabetic patients at home and abroad, the influencing factors and their effects on patients, aiming to provide a theoretical basis for the intervention of stigma in young and middle-aged diabetic patients.

Objective:To explore the components of home care ability of disabled elderly in communities so as to provide a basis for assessment of home care ability among the home disabled elderly.Methods:From July 2018 to May 2019, the semi-structured interview was used to 5 home disabled elderly people, 12 home caregivers and 6 service members for the elderly in community of Beijing. Content analysis was used to analyze and extract the components.Results:The home care ability of the disabled elderly consisted of four components including the economic capacity, human resource, cohesion of home care and care ability of home caregivers.Conclusions:During home care for the disabled elderly, home economic and human resource are guarantees, cohesion of home care is the motive force and care ability of home caregivers is the core of care quality guarantee. It is the important way of improving home care quality of the disabled elderly to fully understand the home care ability and accurately match home care in community.

OBJECTIVETo explore the distribution of the main clinical symptoms and signs of primary biliary cirrhosis (PBC) in a population of individuals with positivity for anti-mitochondrial antibody-M2 (AMA-M2).

METHODSA total of 20 970 persons who participated in routine health examinations at our hospital were tested for presence and level of antinuclear antibodies (ANAs) using an indirect immunofluorescence (IIF) assay and of AMA-M2 by western blotting. The chi-square test was used for statistical analysis.

RESULTSTiters of ANAs more than 1:320 were detected in 1 243 of all the study participants, with 156 of those individuals having detectable AMA-M2.The overall rate ofAMA-M2 positivity was 0.74%, with a significantly higher rate among female subjects (males:0.3% (32/10 550) vs.females:1.2% (124/10 420); x2=55.85, P less than 0.05). Among the AMA-M2-positive population there were 66 cases of abnormal liver function, 58 cases of increased alkaline phosphatase, 72 cases of abnormal findings for routine blood testing, 47 cases of gallbladder disease history, 49 cases of diabetes history, 22 cases of allergy, 75 cases of abdominal discomfort, 38 cases of weakness, 3 cases of jaundice, and 11 cases of pruritus. There were significant differences between the AMA-M2-negative individuals and the AMA-M2-positive individuals.

CONCLUSIONAmong the general population, individuals with substandard states of health, such as those with abnormal findings in routine blood tests and abnormal liver function, should be screened for AMA-M2. This screening will facilitate early diagnosis of PBC and timely initiation of disease management, improving the patient's life quality of life and prolonging their life.

Biomarkers ; Blotting, Western ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Liver Cirrhosis, Biliary ; metabolism ; Male ; Pruritus ; Quality of Life

Objective To analyze the impacts of two different loading methods on the sterilization of glass feeding bottle in hospitals,to confirm the best loading sterilization methods and provide the acceptable product for the clinical department.Methods By purposive sampling the glass feeding bottles sterilized between December 2013 and December 2014 in Central Sterile Supply Department,the First People's Hospital of Shangqiu,were chosen.We divided them into experimental group and control group with each 5 groups (120 bottles).The control group applied medical storage tank to load and sterilize.The experimental group sterilized through innovative stainless steel hollow with cover.Both groups were deposited in the storage rack in the clean area with air 300 000 stage air purification and temperature and humidity meeting the national standards.The professional worker supervised this two items at the same time in validity.In the period of validity,professional personnel implemented visual inspection,a magnifying glass detection and bacterial culture at the same time.Results The visualization and magnifying glass detection qualified rate of 5 packages (120 bottles) in the control group was 75.0％,sterilization quality rate 95.0％ by biological cultivation compared with 95.8％ and 100.0％ in the experimental group (P ＜ 0.05).Conclusions The usage of wrapping tool with innovative hollow stainless steel can ensure the effectiveness and the integrity of the glass feeding bottles,can reduce the medical cost and the occurrence of hospital infection.

Objective:To construct an evaluation index system for the family care ability of the disabled elderly in the community, so as to provide a reference for comprehensively assessing the family care ability of the disabled elderly.Methods:On the basis of literature research, from July 2018 to May 2019, purpose sampling was used to select 5 home disabled elderly people, 12 family caregivers, and 6 community service staff to conduct the semi-structured interview, and the content of the index system was initially constructed. From June 2019 to January 2020, the Delphi method was used to conduct two rounds of consultation with 17 experts, to improve and revise the indicators. The analytic hierarchy process was used to determine the weight of the indicators.Results:After two rounds of expert consultation, an evaluation index system for the family care ability of the disabled elderly was finally formed, including 4 first-level indicators (family care economic capacity, family care manpower, family care cohesion, family caregiver's care ability) , 12 second-level indicators, and 27 third-level indicators. The questionnaire response rate for two rounds of consultation was 100.0%, and the expert's authority coefficient was 0.88. After the second round of consultation, the Kendall coordination coefficients of the first-level, second-level and third-level indicators were 0.647, 0.635, and 0.620 respectively ( P<0.01) . Conclusions:The evaluation index system for the family care ability of the disabled elderly in the community is scientific, reliable and comprehensive. It can provide reference and direction for improving the existing evaluation content, formulating evaluation standards, and then implementing the family care ability evaluation.