1.Application of genetic methods in family-based association study of congenital heart disease
International Journal of Pediatrics 2015;42(5):549-552
Congenital heart disease (CHD) is the most common survivable birth defect in newborns.Pathogenesis of CHD is thought to be associated with environmental and hereditary factors.However,the etiology of most CHD remains unclear.Familial resurgence presents a classic pattern of CHD and data from reviews showed a higher incidence rate in first-degree relatives.Analysis of large multigenerational families could improve the identification of numerous genes and inheritance model in CHD patients.Recent genetic breakthroughs allowed specific evaluation of genetic abnormalities in large families with CHD patients.Next-generation sequencing technologies,genetic linkage analysis and candidate gene analysis have all been applied in the research of family-based CHD.With the development of genetic research technologies, analyses of nuclear famihies or distantly corresponding sporadic cases have generated more progress in CHD studies.Thus, this review will focus on the application of genetic methods in family-based association study of congenital heart disease.
4.Erratum to: Questions about NgAgo.
Shawn BURGESS ; Linzhao CHENG ; Feng GU ; Junjiu HUANG ; Zhiwei HUANG ; Shuo LIN ; Jinsong LI ; Wei LI ; Wei QIN ; Yujie SUN ; Zhou SONGYANG ; Wensheng WEI ; Qiang WU ; Haoyi WANG ; Xiaoqun WANG ; Jing-Wei XIONG ; Jianzhong XI ; Hui YANG ; Bin ZHOU ; Bo ZHANG
Protein & Cell 2017;8(1):77-77
5.Questions about NgAgo.
Shawn BURGESS ; Linzhao CHENG ; Feng GU ; Junjiu HUANG ; Zhiwei HUANG ; Shuo LIN ; Jinsong LI ; Wei LI ; Wei QIN ; Yujie SUN ; Zhou SONGYANG ; Wensheng WEI ; Qiang WU ; Haoyi WANG ; Xiaoqun WANG ; Jing-Wei XIONG ; Jianzhong XI ; Hui YANG ; Bin ZHOU ; Bo ZHANG
Protein & Cell 2016;7(12):913-915
Animals
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Archaeal Proteins
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genetics
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metabolism
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Deoxyribonuclease I
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genetics
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metabolism
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Gene Editing
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methods
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Humans
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Natronobacterium
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enzymology
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genetics