1.DEVELOPMENT OF HUMAN FACIAL CANAL AND FACIAL NERVE
Shuo CHEN ; Zhimin QIU ; Ningsheng ZHOU
Acta Anatomica Sinica 1955;0(03):-
The development of the human facial canal and the facial nerve of 229 temporal sides from 11 weeks fetuses to infancies were studied by histological method. The results showed that the facial canal was formed by the membranous ossification and by cartilaginous ossification. The lateral wall, inferior wall of the horizontal segment and the eminous segment, the superior wall of the labyrinthine segment of the facial canal were formed by the membranous ossification. The sequence of the membranous ossification had some regularities. The rest of the facial canal was ossified in the cartilaginous bone. The development of the facial nerve grew in advanced embrylogical age. The length and width diameters of the facial nerve in the facial canal were almost the largest in size before birth. The size of the facial nerve to that of the facial canal is kept in a more or less constant proportion. It was found that the facial norve was largest at the distal portion of the labyrinthine segment of the facial canal and smallest at the stylomastoid foramen.We put forward the conclusion that the disturbances of the membranous ossification in any portion of the facial canal and the anomalies of the pneumatization of the mastoid process were the main causes for the deficiency of the facial canal.
2.Influence of veneering porcelain thickness on the compressive strength of zirconia all-ceramic crown
Xiaoxue WANG ; Yafei QIU ; Shuo YUAN ; Zhao ZHANG ; Changjun GUO
Journal of Practical Stomatology 2016;32(2):178-181
Objective:To explore the influence of the veneering porcelain thickness on the compressive strength of zirconia all-ceramic crown.Methods:25 zirconia basement crowns with the thickness of 0.5 mm were made by CAD-CAMsystem,and then were divided into 5 groups randomly with the veneering porcelain thickness of 0.5(A),1.0(B),1.5(C),2.0(D)and 2.5 mm(E)respectively. The compressive strength of the samples was measured by a testing machine.Statistical analysis was conducted by SPSS13.0 software. The microstructure of the fractured bonding interface of the specimens was observed by scanning electron microscope(SEM).Results:The compressive strength in group A,B,C,D and E were:(1 279.96 ±42.85)N,(2 235.44 ±50.14)N,(2 216.38 ±48.97)N, (2 169.22 ±60.40)N and (2 028.70 ±47.37)N respectively(A or E vs B,C or D,P <0.01;A vs E,P <0.01;B vs C or D,P >0.05;C vs D,P >0.05).SEMobservation found that in group A and E the bonding interface was uneven and loose,the cracks and spores in veneering porcelain appeared more and larger,and had a more intensive distribution.Conclusion:When the veneering porce-lain is too thick or too thin,the compressive strength of zirconia all-ceramic crown decreases,the thickness of the veneering porcelain should be controled in an appropriate range.
3.MRI characteristics of autoimmune pancreatitis
Xuming LIU ; Qiande QIU ; Shuo LI ; Zhenghan YANG
Chinese Journal of Endocrinology and Metabolism 2010;26(9):782-783
The MRI data of 13 patients with autoimmune pancreatitis (AIP) were retrospectively analyzed. The results showed that the pancreas diffusely enlarged in 10 of 13 cases, and focally enlarged in 3cases. There were 13 cases with decreased signals on T1WI and mildly hyperintense on T2WI in the area with pancreatic lesions, 11 cases with thickened capsule-like structure showing moderate-low signal T1WI and low signal T2WI,and delayed enhancement in dynamic contrast-enhanced MRI, and 10 cases with stenotic common bile duct at the level of pancreas with proximal cholangiectasis. The findings in 9 cases were remarkably improved in followup MRI after glucocorticord treatment.
4.Development and application of automatic dental crown remover
Shuo LIU ; Yanru LIU ; Caixia LIU ; Libin QIU ; Lin WANG ; Wei LI
Chinese Medical Equipment Journal 2015;36(5):49-50
Objective To develop a dental crown remover with the strength provided constantly and adjusted freely.Methods The remover was composed of a shell, a crown hook, a conduction mechanism, a strength generating mechanism and a percussion mechanism. The spring had the explosive force formed in the crown head to destruct the cohesion of the cement.Results The remover could remove the crown, with one hand freed for the protection of abutment and mucous membrane.Conclusion The remover has simple structure and easy operation, and is worth popularizing clinically.
5.Correlation between cytochrome P450 3A5 gene polymorphism and essential hypertension
Fei XIAO ; Jian QIU ; Guoqiang ZHONG ; Zhiyu ZENG ; Ronghui TU ; Yan HE ; Shuo LI
Chongqing Medicine 2013;(25):2991-2993,2996
Objective To study the correlation between the cytochrome P450 3A5 gene polymorphism and essential hypertension (EH) in Chinese population .Methods The real-time PCR genotyping at CYP3A5*3(6986A>G) position was established using Taqman minor groove binding (MGB) probes .Total 170 EH patients and 193 matched controls of Chinese Han population were genotyped at CYP3A5*3(6986A>G) position using this method .Results The GG ,GA ,AA genotyped frequencies were 51 .2% , 42 .4% and 6 .5% for the EH patients and 39 .9% ,50 .8% and 9 .3% for the control group respectively .The risk of EH for person carrying GG genotype was 1 .579 fold of the persons carrying at least one A allele(95% CI:1 .041-2 .395) .Conclusion CYP3A5*3(6986A>G) polymorphism may be associated with EH in Chinese population .The risk of EH is decreased in the persons carrying allele A ,slightly lower levels of systolic blood pressure exists .
6.Detecting underlying malignancy with 18F-FDG PET/CT in patients with suspected paraneoplastic neurological syndrome
Yuan-yuan, GENG ; Shuo, GAO ; Bing-di, XIE ; Qiu-song, CHEN ; Li, CAI ; Yan-qing, LIU
Chinese Journal of Nuclear Medicine 2010;30(3):163-165
Objective To evaluate 18F-fluorodeoxyglucose (FDG) PET/CT in detecting occult malignancy in patients with suspected paraneoplastic neurological syndrome (PNS).Methods Twenty consecutive patients who underwent PET/CT scanning with the indication of suspected PNS were retrospectively reviewed.The gold standard of PNS was either cytology or clinical follow-up, and the final diagnosis was compared with PET/CT findings.Results Of the 20 patients, six were PNS.PET/CT detected nine cases.Six were true positive and three were false positive.The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT were 100% (6/6), 78.57% (11/14), 85.00% (17/20),66.7% (6/9) and 100.00% ( 11/11 ) respectively.The treatment plan was modified based on the PET/CT results in 4 patients.Conclusions 18F-FDG PET/CT may play a role in detecting the underlying malignancy of PNS.It is also valuable in staging of the malignancy thus providing information for therapy decision making.
8.Surgery for left ventricular aneurysm after myocardial infarction: techniques selection and results assessment.
Xin CHEN ; Zhi-bing QIU ; Ming XU ; Le-le LIU ; Ying-shuo JIANG ; Li-ming WANG
Chinese Medical Journal 2012;125(24):4373-4379
BACKGROUNDThe most appropriate surgical approach for patients with post-infarction left ventricular (LV) aneurysm remains undetermined. We compared the efficacy of the linear versus patch repair techniques, and investigated the mid-term changes of LV geometry and cardiac function, for repair of LV aneurysms.
METHODSWe reviewed the records of 194 patients who had surgery for a post-infarction LV aneurysm between 1998 and 2010. Short-term and mid-term outcomes, including complications, cardiac function and mortality, were assessed. LV end-diastolic and systolic dimensions (LVEDD and LVESD), LV end-diastolic and end-systolic volume indexes (LVEDVI and LVESVI) and LV ejection fraction (LVEF) were measured on pre-operative and follow-up echocardiography.
RESULTSOverall in-hospital mortality was 4.12%, and major morbidity showed no significant differences between the two groups. Multivariate analysis identified preoperative left ventricular end diastolic pressure > 20 mmHg, low cardiac output and aortic clamping time > 2 hours as risk factors for early mortality. Follow-up revealed that LVEF improved from 37% pre-operation to 45% 12 months post-operation in the patch group (P = 0.008), and from 44% pre-operation to 40% 12 months postoperation in the linear group (P = 0.032). In contrast, the LVEDVI and LVESVI in the linear group were significantly reduced immediately after the operation, and increased again at follow-up. However, in the patch group, the LVEDVI and LVESVI were significantly reduced at follow-up. And there were significant differences in the correct value changes of LVEF and left ventricular remodeling between linear repair and patch groups.
CONCLUSIONSPersistent reduction of LV dimensions after the patch repair procedure seems to be a procedure-related problem. The choice of the technique should be tailored on an individual basis and surgeon's preference. The patch remodeling technique results in a better LVEF improvement, further significant reductions in LV dimensions and volumes than does the linear repair technique. The results suggest that LV patch remodeling is a better surgical choice for patients with post-infarction LV aneurysm.
Aged ; Female ; Heart Aneurysm ; etiology ; mortality ; surgery ; Humans ; Male ; Middle Aged ; Myocardial Infarction ; complications ; mortality ; surgery ; Ventricular Remodeling
9.Molecular epidemiological study of adenovirus causing acute respiratory infection in children in Hebei Province
Fangzhou QIU ; Mengchuan ZHAO ; Guixia LI ; Le WANG ; Xiaotong YAN ; Weiwei GUO ; Shuo YANG ; Zhishan FENG
Chinese Journal of Microbiology and Immunology 2018;38(12):902-907
Objective To analyze the molecular epidemiology of adenovirus ( ADV) causing acute respiratory diseases and to investigate the mixed infection of ADV and other respiratory pathogens in Hebei Province. Methods Sputum samples were collected from inpatient children with acute respiratory diseases at Children′s Hospital of Hebei Province between June 2017 and May 2018. Multiplex reverse transcription PCR assay was used to detecte 13 kinds of respiratory pathogens. Nested PCR was performed to amplify ADV hexon gene and the amplified products were then sequenced. Results A total of 353 ADV-positive speci-mens were detected in 8839 specimens with a positive rate of 3. 99%. Significant difference in the positive rate of ADV was not observed between male and female patients (χ2=0. 0003, P=0. 99), but found among different age groups (χ2=115. 69, P<0. 001). All isolated ADV strains belonged to 11 serotypes, which were type 1 (16. 15%, 57/353), type 2 (35. 98%, 127/353), type 3 (21. 25%, 75/353), type 4 (1. 13%, 4/353), type 5 (11. 33%, 40/353), type 6 (3. 97%, 14/353), type 7 (8. 22%, 29/353), type 31 (0. 28%, 1/353), type 41 (0. 28%, 1/353), type 55 (0. 28%, 1/353) and type 57 (1. 13%, 4/353). Among the 353 ADV-positive specimens, 259 were mixed infections mainly caused by ADV and human rhinovirus (35. 52%). ADV and respiratory syncytial virus co-infections accounted for 12. 74% and 33. 20% of the mixed infections involved three or more pathogens. ADV could be detected throughout the year, especially in September and April to May. The predominant serotypes were types 1, 2 and 3. The av-erage ages of the two groups of ADV infection alone and ADV mixed infection were (27. 56±24. 67) months and (21. 33 ±20. 28) months, respectively, and the difference between them was statistically significant (P=0. 037). The incidence of ADV 2 infection alone was 25. 77% (25/97), which was lower than that of ADV 2-involved mixed infection [39. 84% (102/256),χ2=6. 05, P=0. 014]. However, the rate of ADV 7 infection alone was significantly higher than that of ADV 7-involved mixed infection [16. 49% 16/97) vs 5. 08% (13/256),χ2=6. 05, P<0. 001]. Conclusion ADV 1, ADV 2 and ADV 3 were the predominant serotypes circulating in Hebei Province from June 2017 to May 2018, especially in September and April to May. The younger the patients were, the higher the incidence would be. ADV 2 was prone to cause mixed infections with other respiratory pathogens, while ADV 7 was less common in mixed infections. Younger pa-tients were more susceptible to mixed infections. The most common co-infection was caused by ADV and hu-man rhinovirus.
10.Research progress of gene therapy for arrhythmias
Chinese Journal of cardiovascular Rehabilitation Medicine 2017;26(6):670-673
Gene therapy is defined as the target gene is import into viral or non-viral carriers and delivered to the tar-get area via direct injection or using catheter-based techniques,highly selectively taking effect,then reduce side effects of systemic medication and improve effectiveness of site-restricted therapy.The present article made a review on application of gene therapy in arrhythmias such as atrial fibrillation and ventricular tachycardia from mechanistic background,application strategies and preclinical outcome of research.