Objective To discuss whether Saccharomyces boulardii sachets can improve the eradication rate and reduce some untoward effects of gastrointestinal tract when adding in the Helicobacter pylori (Hp) standard quadruple therapy.Methods 249 cases infected with Hp were randomly divided into control group(124 cases) and treatment group (125 cases).The control group was treated with standard quadruple therapy:colloidal bismuth pectin capsules,100 mg,tid,po;furazolidone tablets,0.1 g,bid,po;amoxil capsule,1 g,bid,po;rabeprazole sodium enteric-coated capsules,20 mg,qd,po.The treatment group was treated with Saccharomyces boulardii sachets(0.25 g,bid,po)besides.Both groups were treated for 4 weeks.Evaluate the effect of Hp eradication rate by using the method of intent of treatment (ITT) analysis and consistent scenario set (PP)analysis.Results According to the ITT analysis,the eradication rate of control group was 89.52%,and that of treatment group was 96.00%.According to the PP analysis,the eradication rate of control group was 90.00%,and the rate of treatment group was 97.39%.Both analysis results showed the eradication rate of Hp in treatment group was significantly higher than control group(P<0.05).As for reducing the untoward effects such as nausea,inappetence,diarrhea,astriction and erythra,control group was obviously lower than treatment group (P<0.05).Conclusion Compared with standard quadruple therapy only,adding Saccharomyces boulardii sachets can significantly improve the eradication rate of Hp and obviously reduce the untoward effects such as nausea,inappetence,diarrhea,astriction and erythra.It is worth to be generalized and applied in clinical practice.

ObjectiveTo investigate the application effect of doctor-nurse-patient-family four-in-one integrated home care in treatment and rehabilitation of patients with reflux esophagitis.Methods A total of 138 patients with reflux esophagitis,treated in Department of Spleen and Stomach Disease in the Hospital of Shanxi University of TCM from March to October 2016,were selected and divided into control group and observation group according to randomized grouping method and program SAS 8.2 proc uniform. Totals of 69 patients in the control group received conventional nursing care,while other 69 in the observation group were intervened by the doctor-nurse-patient-family four-in-one integrated home care (RE-HC). After completion of the 12-week intervention,total score of symptoms,total effective rate of the clinical treatment,comprehensive score of nursing management effect and quality of life score were compared between the two groups.Results Total score of symptoms in the observation group (16.54±4.82) was obviously lower than that in the control group (28.65±6.55) (Z=12.37,P<0.01). In the observation group,total effective rate of the clinical treatment was 97.10%,the score of nursing management effect was (125.98±3.46),and the total score of quality of life was (86.31±5.80),all higher than those in the control group (χ2/Z=5.90,68.03,1.41;P<0.05).Conclusions In treatment of patients with reflux esophagitis,the doctor-nurse-patient-family four-in-one integrated home care can remarkably improve the patients' symptom score,total effective rate,nursing management effect and the patients' quality of life.