OBJECTIVE:To observe the efficacy and safety of Children resuqing oral lipid in the treatment of acute suppurative tonsillitis. METHODS:112 children with acute suppurative tonsillitis were randomly divided into control group and observation group. Control group was treated with Amoxicillin clavulanate potassium for injection 30 mg/kg,twice a day;based on the treat-ment of control group,observation group was treated with Children resuqing oral lipid,1/4-1/2 bag for <1 year old,1/2-1 bag for 1-3 year(s)old,1-1.5 bag(s)for 3-7 years old,1.5-2 bags for 7-12 years old,3-4 times a day. The treatment course was 5 d. The clinic data was observed,including clinical efficacy,average cooling time and throat disappear time,WBC,CRP level,and CD4+/CD3+,CD4+/CD8+and CD8+/CD3+in vivo before and after treatment and incidence of adverse reactions in 2 groups. RESULTS:The to-tal effective rate in observation group was significantly higher than control group,average cooling time and throat disappear time were significantly shorter than control group(P<0.05). After treatment,WBC and CRP level were significantly lower than before, and observation group was lower than control group;CD4+/CD3+ was significantly higher than before,and observation group was higher than control group;CD4+/CD8+in observation group was significantly higher than before and control group,CD8+/CD3+in con-trol group was significantly higher than before(P<0.05);however,there were no significant differences in the CD8+/CD3+ in obser-vation group before and after treatment,and incidence of adverse reactions between 2 groups (P>0.05). CONCLUSIONS:Based on the treatment of Amoxicillin clavulanate potassium for injection,Children resuqing oral lipid has better efficacy and safety in the treatment of acute suppurative tonsillitis.