Objective To explore the clinical significance of lantus plus acarbose applied for the treatment of elderly diabetes patieats.Methods 84 old diabetes patients treated in our hospital were randomly divided into experimental group and control group. The patients of experimental group were treated with lantus plus acarbose, the control group used normal insulin. To observe the therapeutic effect of two groups. Results The levels of fasting plasma glucose,2 hours postprandial glucose,glycosylated hemoglobin A1C and the occurrence of adverse reactions after the treatment were statistically significant ( P ＜ 0. 05 ). Conclusion Lantus plus acarbose was an effective treatment for elderly diabetes patients, and could obtain the ideal blood sugar and less complications, and clinical effect of the therapy was ideal, and it was worth used widely.