AIM: To determine the effects of valsartan on calcium channel and sodium-calcium exchanger current in isolated ventricular myocytes of congestive heart failure (CHF) rats. METHODS: Eight weeks after coronary ligation, the rats with heart failure were confirmed by measuring the hemodynamic parameters and divided randomly into the group treating with valsartan (CHF-T, 20 mg/kg) and placebo (CHF-C). Sham-operated group rats served as negative controls (PS). Twelve weeks later, 6 rats were selected randomly for the study of ion channel. Single ventricular myocytes of rats were isolated by enzymatic dissociation. The whole-cell patch-clamp recording technique was used to record calcium channel current and sodium-calcium exchanger current. RESULTS: (1) In the hemodynamic variables, HR and blood pressure were not significantly different in three groups. Compared CHF-C with PS group, LVEDP and Cm increased, LVSP and ?d p /d t max decreased ( P 0 05). (4) Na +-Ca 2+ exchanger current in CHF-C group increased significantly. Na +-Ca 2+ exchanger current in CHF-T group was smaller significantly than that in CHF-C group. However, CHF-T group and PS group were not significantly different. CONCLUSION: Administration of valsartan is effective in preventing from cardiac function deterioration, increases calcium channel current and decreases Na +-Ca 2+ exchanger current in ventricular myocytes of heat failure rats.

Objective To explore the application effect of video education combined with feedback method on rehabilitation training in acute ischemic stroke.Methods A total of 182 acute ischemic stroke patients were divided into conventional group and study group,with 91 patients per group,given early rehabilitation nursing intervention,video education method combined with feedback,respectively.Hospitalization time,accuracy of rehabilitation training before discharge,FuglMeyer Assessment (FMA) score and life movement ability score before discharge,on discharge,at 3 and 6 months,rehabilitation training compliance at 6 months after discharge,and nursing satisfaction were compared.Results The study group had lower hospitalization time,higher performance scores of oral and motion demonstration accuracy than the conventional group (P ＜ 0.05).The FMA score and Barthel index before discharge,on discharge,at 3 and 6 months were significantly higher (P ＜0.05),and the time and frequency compliance during hospitalization and after discharge were significantly higher than that of conventional group (P ＜ 0.05).The satisfaction of rehabilitation training was significantly higher than that of conventional group (P ＜ 0.05).Conclusion Video education combined with feedback method can improve mastery of rehabilitation exercise in patients with acute ischemic stroke,increase the compliance of rehabilitation exercise,improve the ability of daily life,and promote the recovery of prognosis,so it is worthy of clinical popularization and application.

Objective To explore the application effect of video education combined with feedback method on rehabilitation training in acute ischemic stroke.Methods A total of 182 acute ischemic stroke patients were divided into conventional group and study group,with 91 patients per group,given early rehabilitation nursing intervention,video education method combined with feedback,respectively.Hospitalization time,accuracy of rehabilitation training before discharge,FuglMeyer Assessment (FMA) score and life movement ability score before discharge,on discharge,at 3 and 6 months,rehabilitation training compliance at 6 months after discharge,and nursing satisfaction were compared.Results The study group had lower hospitalization time,higher performance scores of oral and motion demonstration accuracy than the conventional group (P ＜ 0.05).The FMA score and Barthel index before discharge,on discharge,at 3 and 6 months were significantly higher (P ＜0.05),and the time and frequency compliance during hospitalization and after discharge were significantly higher than that of conventional group (P ＜ 0.05).The satisfaction of rehabilitation training was significantly higher than that of conventional group (P ＜ 0.05).Conclusion Video education combined with feedback method can improve mastery of rehabilitation exercise in patients with acute ischemic stroke,increase the compliance of rehabilitation exercise,improve the ability of daily life,and promote the recovery of prognosis,so it is worthy of clinical popularization and application.