Objective To explore for mentally challenged children, their families after the implementation of com-munity-based management and care, the effect obtained performance.Methods Select mentally disabled children 150 ca-ses as the research object of this experiment, implement necessary community management intervention for children and to give the necessary family care, mainly include the children carry out health education, existence education and encourage children to participate in training activities, etc.Comparing the patient′s psychological state before and after the intervention and the quality of life scores.Results Before the intervention and post-intervention comparison found that children in ath-letic ability, the ability to understand the performance aspects of quality of life scores, and a very significant improvement (p<0.05).In terms of children with inner feelings, after giving intervention also received a significant effect, children with heart felt warm enough.Conclusion For the mentally challenged children, to give them the necessary community manage-ment and home care, improving the quality of life in children with intellectual disabilities and children with enhanced inner feelings, etc., have shown a very significant meaning, highlights the success of community management and family care Ap-plication significance.

Objective To investigate the charateristic CT features of pediatircs reproductive system of endodermal sinus tumor. Methods Thirteen cases with pediatircs reproductive system of endodermal sinus tumor confirmed by surgery and biopsy pathology all underwent CT and contrast-enhanced CT scans,and theire imaging features were then ananlyzed.Results On CT scan,7 cases of testicular or vagina endodermal sinus tumor of children appeared soft tissues mass with uneven density,small patchy hypodense shadows,and ill-defined boundaries.Contrast-enhanced CT scans reveal the solid masses were obvious uneven continuous enhance-ment,but small patchy hypodense shadows were not enhanced,local envelope were enhanced.CT scans reveal that 6 cases of ovaries endodermal sinus tumor showed the large cystic solid mass,predominantly cystic mass,including 2 cases of punctate and patchy cal-cification,and contrast-enhanced CT scans showed that solid part were enhanced obviously and with obvious strengthening vessels shadows.1 case of right ovaries endodermal sinus tumor with fat density shadow and small patchy calcification.Its pathological di-agnosis was the endodermal sinus tumors with mature cystic treatomas.Conclusion CT image has an advantage in the diagnosis of endodermal sinus tumor of the children's reproductive system,especially combined with serum AFP determination.

Brain natriuretic peptide consists of 26 amino acids and has diuretic, natriuretic and hypotensive activities. We have synthesized BNP and its analog (BNP-A) (Mpr4, D-Ala613)-BNP(4-26)-NH2 using solid phase method and examined their biological activities. Our results showed that 1) BNP (10-7mol/L) dilated human basal cerebral artery which was pre-constricted with endothelin, 5-HT and noradrenaline in vitro; 2) both BNP (5 ?g/ rat) and BNP-A (5 ?g/ rat) increased regional cerebral blood flow following i.v. injection in rats; 3) intracerebroventricular injection of BNP (3 ?g/ rat) induced an obvious natriuretic effect when blood volume was extremely expanded with hypoosmotic glucose solution in rats; 4) BNP (5 ?g/ rat) infusion for 60 minutes caused a decline of plasma concentration of angiotensin II and aldosterone at the end of infusion in spontaneous hypertensive rats (SHR), and the bolus injection of BNP (10 ?g/ rat) led to a fall in blood pressure about 1.33kPa. We conclude that BNP is an important peptide in regulating water and sodium metabolism and plays an important role in regulating blood flow to various organs.

ObjectiveToinvestigatetheclinicaleffectofthelowmolecularheparininthetreatmentofoli-gohydramnios in late pregnancy and its influence on pregnant women blood coagulation function.Methods According to didital table 100 patients with oligohydramnios in late pregnancy were divided into the observation group and control group.The treatment group was given routine treatment,and the observation group was given low molecular heparin therapy on the basis of conventional treatment.Results The clinical curative effect score of the observation group was (8.52 ±1.48)points,which was obviously higher than (5.03 ±1.26)points of the control group,the difference was statistically significant(P<0.05).Conclusion For patients with oligohydramnios in late pregnancy,low molecular heparin can be a significant boost for the clinical treatment effect of patients,can promote the use in clinic.

This paper briefly describes the mechanism of neurochemical changes in AD,the roles of the epigenetics,the regulation of gene expression and the mechanism of epigenetics in SAD.On the basis of the basic study on the AD during the decades,researchers initially revealed the mystery of the unfathomable neurochemical changes attack on AD.Especially in recentyears,researchers summarized the abnormal protein expression on SAD into epigenetics disease.This achievement helps researchers point out the new and strategic direction on AD pathogenesis,prevention and control mechanism.With the understanding of biological characteristics of epigenetics,AD needs to be studied in depth.

ObjectiveTo evaluate the clinical efficacy ofYigongpowder withYupingfengpowder for syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia.MethodsA total of 60 patients who had spleen deficiency after azithromycin injection 5 days were randomly divided into treatment group and control group according to the random number table, with 30 in each group. The patients in both received azithromycin suspension for 2 weeks, while the patients in the treatment group received azithromycin suspension and traditional Chinese medicineYigongpowder withYupingfengpowder for 2 weeks. The symptoms score was used to evaluate the clinical efficacy.ResultsThe scores of appetite loss (0.65 ± 1.00vs. 2.32 ± 1.28,t=5.631), abdominal distention (0.73 ± 0.23vs.1.33 ± 0.97,t=3.297) and fatigue (0.72 ± 0.32vs. 1.42 ± 1.18,t=3.136) in the treatment group were significantly lower than those in the control group (all P<0.05). The total effective rate for syndrome of spleen deficiency in the treatment group was significantly higher than thatin the control group(90.0%vs.66.7%;χ2=4.812,P<0.05).ConclusionYigongpowder withYupingfeng powder can significantly improve the symptoms of syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia.

Objective To assess prognostic factors impacted on overall survival in patients with epithelial ovarian carcinoma. Methods Totally 170 patients with stages Ⅰ-Ⅳ epithelial ovarian carcinoma admitted in Shanxi Provincial Cancer Hospital from Jan 2002 to Dec 2005 were analyzed by retrospective analysis. Results The results showed that the prognostic factors of epithelial ovarian carcinomas were related to age, stage, histological type, pathological differential grade, the size of residues lesions and the number of course of chemotherapy (P<0.01). The univariate analysis showed that family history was not related to the survival of epithelial ovarian carcinoma (P > 0.05). Compared with stage Ⅳ,the risk of mortality was 0.005 for stage Ⅰ (95% CI, 0.001-0.024), 0.106 for stage Ⅱ (95% CI,0.038-0.297) and0.361 (95% CI, 0.181-0.718)for stage Ⅲ (P<0.01). The risk of mortality was 0.307 (95% CI, 0.176-0.536) for the patients with residual diameter >2 cm, in comparison with the residual ≤2 cm (P < 0.01). The risk of mortality in patients received < 6 courses of chemotherapy was 8.191 times higher than that in patients received ≥6 courses of chemotherapy (95% CI, 4. 666-14. 379;P < 0.01). Conclusions The major independent prognostic variables for epithelial ovarian carcinoma are stage, the size of residual tumor lesions and the number of courses of chemotherapy. Therefore, the earlier diagnosis, the earlier surgery, sufficient cycles and timely assistant chemotherapy are the key point to improve the survival rates of epithelial ovarian carcinoma.

The hypothesis of tumor stem cells believes that a small proportion of cells which have the stemness property reside in tumor. This population is the cause of tumor formation, growth, metastasis and relapse. Only the therapy targeting this population could make tumors curable. At present, most anti-cancer protocols only kill the majority of differentiated tumor cells and hardly affect the tumor stem cells. That is why most of the therapies do not achieve good results. Disrupting the pathways and niche which regulate the tumor stem cells’ self-renewal, or inducing the tumor stem cells’ differentiation, or targeting the surface markers which distinguish the tumor stem cells from normal stem cells are all probable strategies.

Medical nutrition therapy (MNT)is the basic and long-term treatment of diabetes patients. At present,the dietary structure of type 2 diabetes mellitus(T2DM)patients in China has yet to be further improved. This article focused on the effect,dietary structure,food selection and guarantee of compliance of MNT in T2DM.We recommended that the dietary pattern should be designed based on the traditional dietary habits around the country,combined with people living and working reality. The rational utilization of network platform can improve the efficiency and compliance of nutrition education.

Objective To investigate the clinical curative effect of laparoscopic surgery assisted gonadotropin-releasing hormone agonist ( GnRH -a ) goserelin in the treatment of the severe ovarian endometriosis ( OEM ) . Methods The clinical data of 300 patients with severe OME who received the laparoscopic conservative surgery were retrospectively analyzed.The patients were divided into three groups according to whether assisted the postoperative drug treatment:goserelin group 100 cases, gestrinone group 100 cases, no drug group 100 cases.All patients were followed up for 2 years,the relief situation of pelvic pain,the recurrence rate,pregnancies situation of the patients who had fertility requirements and drug adverse reaction were observed.Results ( 1 ) The pelvic pain remission rates of the GnRH-a group,gestrinone group and no drug group were 98.0%,89.0%,74.0% respectively,the GnRH-a group,gestrinone group were obviously higher than that of no drug group,the differences were statistically significant (χ2 =4.723,4.182,all P<0.05).Goserelin group and the gestrinone group had no statistically significant difference (χ2 =2.012,P>0.05).Follow-up 2 years,the recurrence rates of the goserelin group,gestrinone group and no drug group were 6.0%,14.0%,29.0% respectively,the goserelin group was significantly less than gestrinone group and the no drug group,the gestrinone group was lower than that of the no drug group,the differences were statistically sig-nificant (χ2 =4.982,4.667,all P<0.05).(2)The natural pregnancy rates of the goserelin group,gestrinone group and no drug group were 35.9%(14/39),34.2%(13/38),25.0%(10/40) respectively,there were no statistically significant differences among the three groups(χ2 =1.374,P>0.05).(3)The incidence rate of the tidal fever and night sweating of the goserelin group was higher than the gestrinone group,the incidence rate of the vaginal bleeding, acne and elevated aminotransferase was lower than that in gestrinone group, with statistically significant differences (χ2 =5.028,4.876,4.394,4.876,all P<0.05).Conclusion The laparoscopic conservative surgery assisted gose-relin in the treatment of severe OME can improve the treatment effect,reduce the postoperative recurrence rate,and have less adverse reaction,but cannot increase natural pregnancy rate.