ObjectiveToinvestigatetheclinicaleffectofthelowmolecularheparininthetreatmentofoli-gohydramnios in late pregnancy and its influence on pregnant women blood coagulation function.Methods According to didital table 100 patients with oligohydramnios in late pregnancy were divided into the observation group and control group.The treatment group was given routine treatment,and the observation group was given low molecular heparin therapy on the basis of conventional treatment.Results The clinical curative effect score of the observation group was (8.52 ±1.48)points,which was obviously higher than (5.03 ±1.26)points of the control group,the difference was statistically significant(P<0.05).Conclusion For patients with oligohydramnios in late pregnancy,low molecular heparin can be a significant boost for the clinical treatment effect of patients,can promote the use in clinic.

Brain natriuretic peptide consists of 26 amino acids and has diuretic, natriuretic and hypotensive activities. We have synthesized BNP and its analog (BNP-A) (Mpr4, D-Ala613)-BNP(4-26)-NH2 using solid phase method and examined their biological activities. Our results showed that 1) BNP (10-7mol/L) dilated human basal cerebral artery which was pre-constricted with endothelin, 5-HT and noradrenaline in vitro; 2) both BNP (5 ?g/ rat) and BNP-A (5 ?g/ rat) increased regional cerebral blood flow following i.v. injection in rats; 3) intracerebroventricular injection of BNP (3 ?g/ rat) induced an obvious natriuretic effect when blood volume was extremely expanded with hypoosmotic glucose solution in rats; 4) BNP (5 ?g/ rat) infusion for 60 minutes caused a decline of plasma concentration of angiotensin II and aldosterone at the end of infusion in spontaneous hypertensive rats (SHR), and the bolus injection of BNP (10 ?g/ rat) led to a fall in blood pressure about 1.33kPa. We conclude that BNP is an important peptide in regulating water and sodium metabolism and plays an important role in regulating blood flow to various organs.

Objective To explore for mentally challenged children, their families after the implementation of com-munity-based management and care, the effect obtained performance.Methods Select mentally disabled children 150 ca-ses as the research object of this experiment, implement necessary community management intervention for children and to give the necessary family care, mainly include the children carry out health education, existence education and encourage children to participate in training activities, etc.Comparing the patient′s psychological state before and after the intervention and the quality of life scores.Results Before the intervention and post-intervention comparison found that children in ath-letic ability, the ability to understand the performance aspects of quality of life scores, and a very significant improvement (p<0.05).In terms of children with inner feelings, after giving intervention also received a significant effect, children with heart felt warm enough.Conclusion For the mentally challenged children, to give them the necessary community manage-ment and home care, improving the quality of life in children with intellectual disabilities and children with enhanced inner feelings, etc., have shown a very significant meaning, highlights the success of community management and family care Ap-plication significance.

Objective To investigate the charateristic CT features of pediatircs reproductive system of endodermal sinus tumor. Methods Thirteen cases with pediatircs reproductive system of endodermal sinus tumor confirmed by surgery and biopsy pathology all underwent CT and contrast-enhanced CT scans,and theire imaging features were then ananlyzed.Results On CT scan,7 cases of testicular or vagina endodermal sinus tumor of children appeared soft tissues mass with uneven density,small patchy hypodense shadows,and ill-defined boundaries.Contrast-enhanced CT scans reveal the solid masses were obvious uneven continuous enhance-ment,but small patchy hypodense shadows were not enhanced,local envelope were enhanced.CT scans reveal that 6 cases of ovaries endodermal sinus tumor showed the large cystic solid mass,predominantly cystic mass,including 2 cases of punctate and patchy cal-cification,and contrast-enhanced CT scans showed that solid part were enhanced obviously and with obvious strengthening vessels shadows.1 case of right ovaries endodermal sinus tumor with fat density shadow and small patchy calcification.Its pathological di-agnosis was the endodermal sinus tumors with mature cystic treatomas.Conclusion CT image has an advantage in the diagnosis of endodermal sinus tumor of the children's reproductive system,especially combined with serum AFP determination.

ObjectiveTo evaluate the clinical efficacy ofYigongpowder withYupingfengpowder for syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia.MethodsA total of 60 patients who had spleen deficiency after azithromycin injection 5 days were randomly divided into treatment group and control group according to the random number table, with 30 in each group. The patients in both received azithromycin suspension for 2 weeks, while the patients in the treatment group received azithromycin suspension and traditional Chinese medicineYigongpowder withYupingfengpowder for 2 weeks. The symptoms score was used to evaluate the clinical efficacy.ResultsThe scores of appetite loss (0.65 ± 1.00vs. 2.32 ± 1.28,t=5.631), abdominal distention (0.73 ± 0.23vs.1.33 ± 0.97,t=3.297) and fatigue (0.72 ± 0.32vs. 1.42 ± 1.18,t=3.136) in the treatment group were significantly lower than those in the control group (all P<0.05). The total effective rate for syndrome of spleen deficiency in the treatment group was significantly higher than thatin the control group(90.0%vs.66.7%;χ2=4.812,P<0.05).ConclusionYigongpowder withYupingfeng powder can significantly improve the symptoms of syndrome of spleen deficiency in children with mycoplasma pneumoniae pneumonia.

This paper briefly describes the mechanism of neurochemical changes in AD,the roles of the epigenetics,the regulation of gene expression and the mechanism of epigenetics in SAD.On the basis of the basic study on the AD during the decades,researchers initially revealed the mystery of the unfathomable neurochemical changes attack on AD.Especially in recentyears,researchers summarized the abnormal protein expression on SAD into epigenetics disease.This achievement helps researchers point out the new and strategic direction on AD pathogenesis,prevention and control mechanism.With the understanding of biological characteristics of epigenetics,AD needs to be studied in depth.

Signal transduction is a very fine and complicated process that indudes participation in the cell propagation, division, maturation and apoptosis.Under normal circumstance disabled-2( Dab2) in human tissues participates in the signal transduction of the cell in order to allow the body to keep normal functions,but under some circumstances the absence of Dab2 influences the normal signal transduction path,leding to atypical cell changes.and the generation of tumors.This paper is a review on the construction and function of Dab2 and its related gene as well as the relation of Dab2 and tumors generation.

Matrix Metalloproteinases is one of the critical enzymes that produce great influence during tumour invasion and metastasis. Single nucleotide polymorphism is single basic group changed at chromosome DNA sequence in certain site. MMP-1 promotor gene additional inserts guanopterin G at site -1607bp. In the tumor crowd, 2G homozygote has higher proportion. MMP-3 promoter region has a single adenine mononucleotide polymorphism site at -1171bp. MMP-3 5A genetype may increase the risk of lymphatic metastasis and have certain correlation with susceptibility

Background and purpose:Cervical cancer is one of the common disease in women in china.Radical surgery remains the first choice for patients with early-stage cervical cancer.However,the majority of patients with bulky disease have lymph nodes or metastases when diagnosed.Palatinum-based neoadjuvant chemotherapy has been utilized in locally advanced cervical cancer with the aim of improving response and survival.The study was to evaluate the effect of neoadjuvant chemotherapy followed by radical surgery for the patients with locally bulky Ⅰ_(B2) and Ⅱ_A cervical carcinoma.Methods:Between September 2003 and February 2004,51 untreated patients with Ⅰ_(B2) and Ⅱ_A cervical carcinoma were enrolled in study group,and were treated with neoadjuvant chemotherapy with cisplatin,vincristine and bleomylin for one cycle followed by radical hysterectomy and pelvic lymphadenectomy;another 51 patients as control group were treated with radical surgery alone.The tumor size,depth of stromal invasion,lymph node metastasis and involvement of surgical specimens were assessed.Results:The overall clinical response rate was 41.2%.There were no complete and progressive ones.The blood loss during operation was 116.82?45.50ml,it was significantly lower than that in control group(P

Objective To analyze the expression of BDNF, NGF,GFAP in Wistar rat pretectel area and determine the relation between neuron damage and neurotrophin change of pretectal area and retinal neurodegeneration in the early stage of diabetes. Methods Male Wistar rats weighing about 200 g were used to create diabetic animal model by injecting STZ. Wistar rats were killed by heart perfusion with 4% FDP at 1-week, 2-week and 1-month after diabetes. The dissected pretectal area was used to determine the expression of BDNF, NGF and GFAP with immunohistochemistry. Results In pretectal area of diabetic rat, the expression of BDNF and NGF began to decrease from 1-week DM, the expression of GFAP began to increase from 2-week DM. Conclusions There are neuron damage and neurotrophin decrease in the pretectal area in the early stage of diabetes. Neurodegeneration and neurotrophin decrease in pretectal area, which is the target tissue of retina, might be one of the reasons resulting in retinal neurodegeneration at the early stage of diabetes.