In the recent aging society, many strategies against cerebral diseases including dementia are needed.As hand massage treatments promote blood flow for muscle fatigue and other disorders, ultrasonic vibration may promote cerebral blood flow.A novel, long wavelength ultrasonic vibration device with high permeation (less than 30 kHz, 2 mW/cm2) was applied to investigate cerebral blood flow before and after the frontal or occipital trans-cranial irradiation. In this study, the frontal or a mixture of the frontal and the occipital irradiation were conducted respectively on Xe gas X-ray CT, and SPECT experiments in healthy adults who did not have any excluding criteria. From the results, we confirmed that the low mill watt ultrasonic vibration emitted by the device promoted cerebral blood flow.

Behavioral and psychological symptoms were examined by psychiatric and cognitive functional evaluation in cognitive dysfunction patients who received weak ultrasound stimulation and drugs. We found great improving effects on motor symptoms for the first time in this study.