1.Research progress of platelet gel in wound healing
Journal of Medical Postgraduates 2017;30(3):333-336
The platelet gel (PG) is mainly made of platelet rich plasma (PRP), which has been increasingly and widely used as a source of growth factors .PG releases platelet derived growth factor , vascular endothelial cell growth factor , transforming growth factor β, epidermal growth factor , and insulin like growth factor 1.These growth factors are necessary for wound healing .Re-cently studies demonstrated that PRP and PG were effective in treating ulcers , burning, osteoarthritis and arthromeningitis .This article will review the bionomics , the mechanism of promoting wound healing and clinical applications of PG .
2.Research status of pluripotent stem cells from different origins
International Journal of Biomedical Engineering 2011;34(2):122-125
Pluripotent stem cells are type of cells that can differentiate into cells of ectoderm,mesoderm and endoderm layers.Cells isolated from developing embryos such as embryonic stem cells,embryonic germ cells,as well as cells derived from adult tissues and bone marrow and testis,have been proved to be pluripotent.Recent studies demonstrated that differentiated cells from adult could be reprogrammed to become pluripotent by genetic manipulation.The characteristics of pluripotent cells from different origins are summarized in this review,and the possible relationship between those populations is discussed.
3.Crystallography,morphology,and thermal properties of starch in Fritillaria thunbergii and F.ussurensis as well as comparison with potato starch
Chinese Traditional and Herbal Drugs 1994;0(08):-
Objective To fully understand the medicinal plants of Fritillaria L.,the physicochemical properties of starch in two species of Fritillaria L.,F.thunbergii and F.ussurensis.were investigated by means of various analytical methods.Methods The properties of starch in the two different species of Fritillaria L.were compared by X-ray diffraction,scanning electron microscope(SEM) and themogravimetric analysis(TGA).Results The crystal type of starch in the two species of Fritillaria L.was the characteristic B-type which was in consistent with that of potato starch.The degrees of crystallinity of F.thunbergii starch and F.ussurensis starch were about 29.9% and 20.1%,respectively.However,the degree of crystallinity of the potato starch was 44.9%.From the crystallinity degree of the starch in two species of Fritillaria L.,it could be concluded that the content of amylose in F.ussurensis starch was higher than that in F.thunbergii starch.The granule size of the starch in two species of Fritillaria L.ranged from 5 to 40 ?m,which were all smaller than that of the potato.The starch granule in two species of Fritillaria L.was in cycloidal or elliptic-shape.It could be concluded that the thermal stability of the starch in two species of Fritillaria L.was different due to the different structures of different starch in various plants by TGA.Conclusion The physicochemical properties of starch in two different species of Fritillaria L.differ a lot due to their geographical origin.
4.Diagnosis and treatment of drug-induced pancreatitis
Journal of Clinical Hepatology 2014;30(8):722-725
Drug-induced pancreatitis (DIP)belongs to gastrointestinal drug-induced diseases.With the wide use of drugs,the number of drugs that may induce DIP is increasing.Since there are not specific clinical indicators for detecting DIP or a complete diagnostic and thera-peutic process for DIP,its diagnosis is often missed.The epidemiology and pathogenesis of DIP,as well as drugs inducing DIP and their classifications,are reviewed.It is stressed that careful collection of medication history of DIP patients and timely discontinuation of suspected pharmacological agents are the key to diagnosis and treatment of this disease,and the patients should be informed of the related drugs that in-duce DIP to prevent its recurrence.
5.Forty-four cases of cervical spondylosis with dissociated motor loss in upper extremity treated with needle scalpel combined with traction.
Shujun WANG ; Liantai LI ; Shaomei WANG
Chinese Acupuncture & Moxibustion 2015;35(1):30-31
Acupuncture Therapy
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Adult
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Female
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Humans
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Male
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Middle Aged
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Spondylosis
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physiopathology
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therapy
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Traction
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Upper Extremity
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physiopathology
6.The relation of matrix metalloproteinase-7 mRNA with lymphatic micrometastasis in gastric carcinoma
Shujun GUO ; Fuchun WANG ; Yongyan LI
Chinese Journal of General Surgery 2001;0(07):-
Objective To investigate an effective method for detecting lymphatic micrometastasis in gastric carcinoma.Methods RT-PCR technique was applied to examine MMP-7 mRNA in 94 lymph nodes in 24 cases of gastric carcinoma.Results Routine pathological method detected lymphatic metastasis in 54 lymph nodes,while MMP-7 mRNA RT-PCR showed positive in 78 lymph nodes. When re-examination for the 28 negative lymph nodes in the initial pathological examination and positive in RT-PCR, 8 lymph nodes with metastasis were found by routine pathological method.2 of 5 patients whose lymph nodes were negitive in pathological examination,but positive in MMP-7mRNA were found liver metastasis 16 and 22 months after radical gastrectomy. Conclusions MMP-7 mRNA RT-PCR is a sensitive method for detecting lymphatic micrometastasis for patients with gastric carcinoma. It is a great help for eluvating the postoperative prognosis and supplemental treatmemt.
7.The construction of driver' s personality trait model of armed police force
Wen ZHANG ; Shujun YU ; Dan WANG
Chinese Journal of Behavioral Medicine and Brain Science 2010;19(8):741-742
Objective To investigate the personality characteristics of the drivers in the Armed Police Force ( CAPF), as well as construct a personality traits model for drivers and evaluation criteria. Methods Adopting Sixteen Personality Factor Questionnaire(16PF) to collect data from 1187 CAPF drivers in Beijing,Sichuan,Inner Mongolia and Yunnan. Results The paper concludes that career personality traits of CAPF drivers are made up of 4 factors: stability and self-control, self-motivation and cooperation, fantasy and openness, intelligence and candor, which explain 50.13% of the total variance. Conclusion The four factors basically construct the personality trait model of CAPF drivers. They could also be of great significance in recruiting, training and evaluating drivers.
8.Preparing acellular nerve allografts by combined freeze-thaw and chemical methods
Shujun GUAN ; Wei WANG ; Yan LI
Chinese Journal of Tissue Engineering Research 2015;(12):1914-1918
BACKGROUND:Host immune rejection is the main problem for nerve alograft in the repair of nerve defects. Therefore, how to avoid and minimize the immune rejection is the key to the success of nerve alografting. OBJECTIVE: To develop a new nerve pretreatment method by which Schwann cels and myelin can be removed from the peripheral nerve of dogs while the basilar membrane can be reserved integraly in order to obtain acelular nerve alografts. METHODS:Bilateral sciatic nerves from healthy adult dogs were taken and pretreated with the combined freeze-thaw and chemical methods folowed by microscopic observation of ultrastructural features, histological staining and western blot analysis of its ingredients. RESULTS AND CONCLUSION:Pretreated acelular nerves with good ductility and excelent epineurium toughness were empty basal lamina tubes with no Schwann cels, myelin and fragments that were al removed thoroughly, but the basilar membrane was fuly retained. These findings indicate that the optimized combination of freeze-thaw and chemical methods can efficiently clear Schwann cels and myelin which are the major antigenic components in the peripheral nerve, while preserve the basilar membrane to promote nerve regeneration. Therefore, this method can be an ideal method for preparation of tissue engineered nerves.
9.Betatrophin and glucose-lipid metabolism
Shujun ZHAO ; Mingming WANG ; Shiwei LIU
Chinese Journal of Endocrinology and Metabolism 2015;31(3):288-290
Betatrophin,discovered in 2013,is a protein secreted by liver,white adipose tissues,and brown adipose tissues.Betatrophin can improve glucose tolerance in mice by promoting islet β cell proliferation and increasing the number of β cells significantly and specifically.At the same time,Betatrophin is involved in lipid metabolism.Betatrophin may work as the new target for treatment of diabetes and disorders of lipid metabolism.