Objective:To investigate the effect of phloroglucinol combined with sufentanil on catheter-related bladder discomfort (CRBD) during anesthesia recovery in patients undergoing lobectomy for lung cancer under general anesthesia.Methods:A total of 95 lung cancer patients from the Cangzhou Central Hospital from May 2020 to June 2022 were selected as the study subjects and randomly divided into a control group (47 cases) and an observation group (48 cases) using a random number table method. The control group received intravenous injection of sufentanil approximately 15 minutes before the end of the surgery, while the observation group received intravenous injection of phloroglucinol combined with sufentanil. The recovery progress, lung function, relevant serum indicators, and occurrence of CRBD within 4 hours after surgery were compared between the two groups.Results:The observation group had shorter eye opening, free breathing, and extubation times than the control group (all P<0.05). Compared with before surgery, there were significant fluctuations in forced vital capacity (FVC), oxygenation index (OI), and partial oxygen pressure (PaO 2) during anesthesia resuscitation and 1 day after surgery in both groups (all P<0.05); The fluctuation amplitude of FVC, OI, and PaO 2 during anesthesia resuscitation and 1 day after surgery in the observation group was significantly smaller than that in the control group (all P<0.05). Compared with before surgery, hypoxia inducible factor-1α (HIF-1α) increased and brain-derived neurotrophic factor (BDNF) decreased in both groups on the first day after surgery (all P<0.05); The HIF-1α of the observation group was significantly lower than that of the control group on the first day after surgery, and the BDNF was significantly higher than that of the control group (all P<0.05). The comparison of the incidence of CRBD between the two groups at 4 hours after surgery showed that the observation group [12.50%(6/48)] was lower than the control group [31.91%(15/47)] (χ 2=4.286, P<0.05). Conclusions:The combination of phloroglucinol and sufentanil in general anesthesia patients undergoing lobectomy for lung cancer can reduce the occurrence of CRBD during anesthesia recovery, reduce the impact on lung function and serum HIF-1α and BDNF levels, and facilitate patient recovery.