BACKGROUND: Cerebral infarction can not only directly cause depression, but also indirectly influence psychological mood so as to cause negative effect during therapeutic process at various degrees.OBJECTIVE: To study the psychological mood and related factors of the inpatients with cerebral infarction.DESIGN: Cross-section observation.SETTING: Neurological Department of Meizhou People's Hospital of Guangdong Province.PARTICIPANTS: A total of 91 inpatients with cerebral infarction were selected from Meizhou People's Hospital of Guangdong Province from 2000 to 2002. All patients were diagnosed as cerebral infarction with clear mind and stable illness with CT. They were inquired to answer questionnaires individually.METHODS: ① Ninety-one patients with cerebral infarction were inquired questionnaires individually with Self-Rating Anxiety Scale (SAS) and Selfrating Depression Scale (SDS). Both scales contained 7 questions and the total scores were 0-21 points. If scores were more than 9 points, patients were diagnosed as anxiety or depression. ② Induction of depression and anxiety was evaluated on the aspects of physical and social factors. Physical factors included dizziness, headache, agrypnia, active disorder of limbs (muscle force was lower than grade 4 and patients could not walk individually) and poor response (pulmonary infection, urologic infection, bedsore,hemorrhage of alimentary tract, febrile, etc.). Social factors included age,sex, marriage, education, careful degree, economic status (whether patients were able to afford all cost of hospitalization or not) and overtime of hospitalization (＞ 1 month). Results were assessed with Binary analysis. The relative risk of value was expressed as Exp (B), and B means partial regression coefficient.MAIN OUTCOME MEASURES: Correlation among depression, anxiety,physical factor and social factor of patients with cerebral infarction.RESULTS: All 91 patients were involved in the final analysis. ① Correlation of depression with physical and social factors. Of the 91, 38 patients (41.8%) suffered from depression. Therefore, depression was closely correlated with physical and social factor. Physical factors of induction of depression, such as headache, dizziness, active disorder of limbs and poor response, wereas higher than those patients who did not have (P ＜ 0.01).Social factors of incidence of depression of patients who had poor care and overtime of hospitalization were increased (P ＜ 0.01). Onset of depression was not related to age, sex, marriage, educational level, economic status and sleeping status (P ＞ 0.05). ② Correlation of anxiety with physical factor and social factor: Of the 91 patients, 28 cases (30.8%) had anxiety;therefore, anxiety was closely correlated with physical and social factors.Physical factors of induction of anxiety, such as poor response and slow recovery of paralysis, were higher than those patients who did not have (P＜ 0.05). Social factors of induction of anxiety in female patients who had high educational level, poor care and poor economic status were increased (P ＜ 0.05). Onset of anxiety was not related to age, marriage, time of hospitalization, headache, dizziness and asomnia (P ＞ 0.05).CONCLUSION: Anxiety and depression are the most common psychological disturbances in patients with cerebral infarction, which are closely correlated with physical and social factors. Thus psychotherapy and care should be performed in inpatients with cerebral infarction.

0.05).Conclusion The serum cTnT is not useful for diagnosing the severity of anthracycline induced cardiactoxicity.

Objective To compare the effectiveness of arthroscopy assisted percutaneous internal fixation and open reduction and traditional surgery tibial plateau fractures.Methods From August 2013 to April 2014, 78 patients with tibial plateau fractures according to random number table were divided into group A and group B, 39 cases in each. A group of traction using arthroscopic surgery, group B with traditional open bag reduction surgery.Results The operation time, intraoperative and postoperative bleeding less and wound lesion area was shorter and less in group A than that in group B; while the healing time and HSS score was faster and higher than that in group B. The difference was statistically significant (P < 0.05); the follow-up time of the two groups show no significant difference (P > 0.05); postoperative complication rate in group A was lower than that in group B, and there is significant difference (P < 0.05).Conclusion Both treatment methods can achieve good clinical results, but arthroscopically assisted treatment of tibial plateau fractures reset shorter operative time, less blood loss, healing time is shorter, less complications, but higher HSS score, etc., which reduced the suffering of patients and improved the outcome.

N ⁶-methyladenosine (m⁶A) modification is critical for mRNA splicing, nuclear export, stability and translation. Fat mass and obesity-associated protein (FTO), the first identified m⁶A demethylase, is critical for cancer progression. Herein, we developed small-molecule inhibitors of FTO by virtual screening, structural optimization, and bioassay. As a result, two FTO inhibitors namely 18077 and 18097 were identified, which can selectively inhibit demethylase activity of FTO. Specifically, 18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells. In addition, 18097 reprogrammed the epi-transcriptome of breast cancer cells, particularly for genes related to P53 pathway. 18097 increased the abundance of m⁶A modification of suppressor of cytokine signaling 1 (SOCS1) mRNA, which recruited IGF2BP1 to increase mRNA stability of SOCS1 and subsequently activated the P53 signaling pathway. Further, 18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein alpha (C/EBPα), and C/EBPβ. Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells. Collectively, we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer.