More than 40 institutions have set up the specialty of medical law in order to train inter-disciplinary talents of medical law.Many scholars undertook extensive research aiming at strengthening and developing this new specialty,but many problems still existed in its teaching and the quality of the graduates was been questioned.Through in-depth analysis of the existing research,we pointed out three problems of the current research:being subjective and lacking data support; confining to the ivory tower and lacking contact with the social; limiting to scholars and teachers and lacking retrospective thinking and critique from postgraduates.

Objective To observe the efficacy and complication of laser subepithelial keratom ileusis (LASEK) combined with mitomycin C (MMC) in treatment of high myopia.Methods 118 cases ( 236 eyes) diagnosed as high myopia were treated by LASEK combined with MMC.The changes of vision,refractive regression,postoperation pain and haze were observed.Results 7-days after operation,all patients' post-operation relief.6-months after operation,the quantity of vision reached or exceeded BCVA were 228 cases ( 96.61％ ),average refraction wsa ( + 0.54 ± 0.24 ) D,the incidence of haze was 4.66％.Conclusion Is safe the LASEK combined with MMC in treatment of high myopia,effective,low incidence of haze.

The teaching method of histology and embryology experiment course are dis-cussed in this article and the teaching test,and some thoughts and experiences about how to im-prove the learning activeness of students are introduced as well.

Objective:To investigate the effect of Operation Maps application on relieving anxiety of patients of the nurses of operation room preoperative visits. Methods:39 cases of operation were randomly divided into the application of operation maps 19 cases and routine visit group 20 cases, regular visiting group received routine preoperative interview content, and on the basis of content, the original application mapping group are visited by nurses carrying atlas album, and according to the related content the nurses explain to patients in the album when they introduce the patients the operating room environment surgery, surgical notes, position, etc. At the same time, the self rating anxiety scale measurement measures the anxiety of patients when they are admitted and after into operation room, and blood pressure, heart rate, pain intensity, the first time getting out of bed, exhaust time, clearing time, and they compare the difference. Results:The anxiety values of the original application mapping group mapping group, systolic blood pressure, heart rate are lower than regular visits group(t=2.28, t=4.756, t=10.28;P<0.05). Intensity of pain after operation in the two groups , get out of bed the first time, exhaust time showed no significant differences(t=3.04, t=3.06, t=2.56;P<0.01). Conclusion:Application of operation atlas of systematic, standardized preoperative visit is an important psychological guidance, and it can reduce the anxiety level of patients and effectively improve the quality of medical operation period.

Atherosclerotic model of rabbit was established by feeding heavy dosage ofcholesterol for 60 days and then withdrew it for 30 days. The relation between cholesterolcontent, lipld peroxide (LPO), activity of antioxidative enzyme and the evolution of ath-erosclerotic lesions was observed. It was found that the serum cholesterol level increasedwith the increased duration of cholesterol feeding and reached a peak at the 60th day,then decreased rapidly after feeding was stopped. However the LPO level didn't fall, in-stead it was increased continuously to a much higher level than that of the control. Theanti-oxidative enzymes SOD and GSH-Px showed compensatory increase at the early stageof high LPO level. There after, it was decreased and was kept in lower level than thatof the control. There were developed atherosclerotic lesions of various degree in aorta,pulmonary and coronary arteries. Even one month after the stop of cholesterol feeding,progressive changes, such as large amount of smooth muscle cell proliferation and inflam-matory cell infiltration were observed, and the lesions became much more severe thanbefore. These results suggested that the exess of LPO in the serum resulted in inhibitionof anti-oxidative enzyine activity Which might play an important role in the initiatingand developing of atherosclerosis.

Objective To observe the effect of Dachengqi granule on degree of illness, blood levels of inflammatory mediators, incidence rate and mortality of multiple organ dysfunction syndrome (MODS) so as to discuss its therapeutic mechanism on MODS. Methods A total of 51 patients with systemic inflammatory response syndrome in intensive care unit (ICU) were randomly divided into treatment group (n=26) and control group (n=25) for an observation of clinical manifestation and prognosis. The plasma levels of endotoxin, tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10) and human leukocyte antigen DR (HLA-DR) of each patient were measured in order to determine the curative effect of Dachengqi granule. Results The plasma level of endotoxin in treatment group was ameliorated more significantly than that in the control group. Dachengqi granule could down-regulate the levels of proinflammatory mediators including TNF?, IL-1? and IL-6 and antiinflammatory mediators including IL-4 and IL-10 and up-regulate the expression of HLA-DR (P

Objective To observe the effect of passive smoking on Clara cells and secretion of Clara cell secretory protein (CC16) in rat lung tissue and to find some relations between passive smoking and chronic inflammation in the lung. Methods 40 male rats were randomly divided into 4 groups: passive smoking for 1 month (group 1), 2 months (group 2), and 3 months (group 3) and control group (n=10). The change of Clara cell ultrastructure was detected through transmission electron microscope and the lung pathology was examined by HE stain. The expression of CC16 mRNA in the lung was detected by RT-PCR. The number of Clara cells and synthesis of CC16 were detected by immunohistochemistry, the CC16 level in BALF was detected by ELISA. Results The ultrastructure of Clara cells in group 3 was destroyed greatly and the formation of pneumatocele was observed. The percentage of Clara cells in terminal bronchioles in group 2 and group 3 significantly decreased than that of the control(P

BACKGROUND:Angelica polysaccharide has the function of enriching blood and promoting blood circulation, but how to improve the hematopoietic microenvironment and promote hematopoiesis has become one of the hot topics. OBJECTIVE: To investigate the effect of angelica polysaccharide on Sca-1+, CD34+ hematopoietic stem cells and intercellular adhesion molecule 1 level in bone marrow stromal cells in mice. METHODS:Mouse models of hemorrhagic anemia were made and then randomly divided them into control group, low-concentration angelica polysaccharide group and high-concentration angelica polysaccharide group. Angelica polysaccharide groups were intraperitoneally injected with the corresponding concentration of angelica polysaccharide (4, 6 mg/kg) for continuous 6 days, while the control group was injected with equal amount of normal saline. General conditions of the model mice were observed. Peripheral blood red cells were counted by automatic blood cell analyzer. Bone marrow hematopoietic stem cels were counted by magnetic bead sorting technique and flow cytometry. Proliferation of bone marrow stromal cells was detected by MTT method. Expression of intercellular adhesion molecule-1 in bone marrow stromal cells was detected by flow cytometry. RESULTS AND CONCLUSION:Angelica polysaccharide had no obvious effect on the body mass of hemorrhagic anemia mice (P > 0.05). The number of peripheral blood cells, the percentage of bone marrow CD34+ and Sca-1+ cells, the number of bone marrow stromal cells and the level of intercellular adhesion molecule 1 were ranked as follows: high-concentration group > low-concentration group > control group (P < 0.05). To conclude, angelica polysaccharide could promote the proliferation of bone marrow stromal cells and increase the expression of intercellular adhesion molecule 1, thereby promoting the proliferation of hematopoietic stem cells and regulating their functional activities.

Objective]To study Professor Wang Kungen's therapeutic principles in treating functional dyspepsia by data mining therapy. [Method]First, establish Wang Kungen's medical records database;then do data standardization and data mining.[Result]There are total y 408 cases that meet the demand. Postprandial distress syndrome is the major subtype of senile group while epigastric pain syndrome is the major subtype of non senile group. The major patterns of syndrome of FD in Professor Wang Kungen's medical records are as fol ows: liver qi attacking the stomach, deficiency and stagnation of spleen Qi, disharmony of stomach qi, stagnation of qi and accumulation of dampness, phlegm-heat harassing the inner body. The major prescriptions are as fol ows:ErChen Decoction, ZuoJin Pil s, SiJunZi Decoction, SiNi Powder, LiuJunZi Decoction, XiangSu Decoction, WenDan Decoction. There is close correlation between prescriptions and patterns as fol ows:liver qi attacking the stomach and SiNi Powder, ZuoJin Pil s;stagnation of qi and accumulation of dampness and ErChen Decoction,PingWei powder;phlegm-heat harassing the inner body and WenDan Decoction, ErChen Decoction; There is close correlation between herbs as fol ows: Processed Rhizoma Pinel iae and Tangerine Peel, Processed Rhizoma Pinel iae and Poria cocos; Rhizoma Coptidis and Processed Evodia rutaecarpa; Fructus Aurantii and Processed Mangnolia officinalis; Radix Bupleuri and Radix Paeoniae Alba; Poria cocos and Atractylodes;Tangerine Peel and Caulis Peril ae; Poria cocos and Codonopsis pilosula; Radix Bupleuri and Curcuma aromatica. [Conclusion]The incidence and subtype of FD between female group and male group is different. Professor Wang Kungen's therapeutic principles in treating FD are clearing liver and adjusting stomach, soothing liver-qi stagnation,harmonizing stomach and lowering adverse qi, promoting the circulation of qi and resolving dampness and clearing phlegm heat.

Objective To assess the effect of nicotinic acid on hyperphosphatemia in maintenance hemodialysis (MHD) patients.Methods Twenty-six MHD patients with stable disease condition and hyperphosphatemia that could not be successfully controlled by conventional methods were selected.All patients were treated with oral nicotinic acid for 20 weeks.The changes of serum calcium,high sensitivity Creactive protein (hs-CRP),albumin (ALB),aspartate aminotransferase (AST),alanine aminotransferase (ALT),gamma-glutmyltransferase (GGT),total bilirubin (TBIL),derect bilirubin (DBIL),high density lipoprotein cholesferol (HDL-C),low density lipoprotein cholesferol (LDL-C),triacylglycerol (TG),total cholesterol (TC),intact parathyroid hormone,hemoglobin,platelet count,etc were observed before and after treatment.Results Two patients withdrew from this study because.of pruritus and diarrhea after two weeks of oral nicotinic acid.In 24 cases,compared with that before treatment,the serum phosphate,calcium-phosphorus product was decreased [(1.49 ± 0.19) mmol/L vs.(2.13 ± 0.16) mmol/L,(4.40 ± 0.49)mmol2/L2 vs.(5.45 ± 0.36) mmol2/L2] and HDL-C was increased [(1.45 ± 0.14) mmol/L vs.(1.18 ± 0.15)mmol/L] after treatment,and there was significant difference (P ＜ 0.05).There was no significant difference in the serum calcium,iPTH,LDL-C,TG,TC,ALB,AST,ALT,GGT,TBIL,DBIL,hs-CRP,platelet count,hemoglobin between before and after treatment (P ＞ 0.05).Conclusions Nicotinic acid is effective as all adjuvant measure in control of hyperphosphatemia in patients on MHD and can increase HDL-C.It provides a new approach for the treatment of hyperphosphatemia.