Magnetic resonance imaging ( MRI ) findings were studied in 19 patients with non-dementia Parkinson′s disease ( PD) Hoehn-Yahr Stage 1 and 1.5 and 38 healthy subjects.The width and area of pars compacta of substantia nigra ( SNc) , substantia nigra ( SN) and midbrain were measured.The width and area ratios of SNc to SN were calculated.Compared with controls, the widths of right SNc was narrower, bilateral ratios of SNc to SN width were decreased in PD group.As to the area of substantia nigra, there was no significant difference between PD and controls.The width of left SN and the ratio of right SNc to SN width was negatively correlation with age of patients.The ratio of left SNc to SN width, the area of bilateral SNc and left SN, as well as the ratio of right SNc to SN area had negative correlation with the disease duration;however, there was no correlation with gender, Hoehn-Yahr Stage, the Unified Parkinson disease rating scale score, mini mental state scale, education years, levodopa equivalent daily dose, Hamilton Depression Scale or Hamilton Anxiety Scale in PD group.The results indicate that there are bilateral structural changes of SN in unilateral PD patients, which may be more significant with increasing disease duration.The measurement of SNc width and SN area can be used as an objective indicator for diagnosis and disease progression monitoring of PD.

Objective To explore the curative effects of artificial skin(hydrocolloid dressing) and erythromycin ointment in the treatment of neonatal skin injury, and to provide theoretical evidences for the promotion of clinically rapid recov-ery of neonatal skin injury and the improvement of curative effects. Methods A total of 160 patients with neonatal skin injury who were treated in our hospital from March 2014 to March 2015 were selected. They were randomly and aver-agely assigned to two groups, research group and control group. Infant patients in the control group were given the treatment of erythromycin ointment, and infant patients in the research group were given the treatment of artificial skin (hydrophilic dressing). Wound healing time, average frequency of dressing change, incidence of complications, non-cure rate and effective rate of treatment were compared between the two groups of infant patients. Results In infant patients of the research group, wound healing time was (4.47±0.76) d, average frequency of dressing change was (3.18±0.52) times, incidence of complications was 5.00%, non-cure rate was 3.75% and effective rate of treatment was 95.00%. All in-dices in the research group were significantly better than those in the control group, and the differences were statisti-cally significant (P<0.05). Conclusion Artificial skin (hydrophilic dressing) in the treatment of neonatal skin injury is able to promote the wound healing rapidly, can reduce the frequency of dressing change and improve the effective rate of treatment.

Objective To explore the structural changes of basal ganglia(subcortical nuclei of cerebral hemisphere)in Parkinson's disease(PD)based on magnetic resonance imaging(MRI)and their relationship with clinical status,and to find neuroimaging biomarkers that are valuable for early diagnosis and disease progression monitoring in PD.Methods Three-dimensional-T1WI and T2WI were applied to 54 PD patients(35 in tremor-dominant PD group,19 in akinetic-rigid-dominant PD group)and 35 healthy controls using 3.0 T MRI scanner.Voxel-based morphometry was used to investigate the volume changes of basal ganglia(subcortical nuclei of cerebral hemisphere, including caudate nucleus, putamen, and globus pallidus).Results Compared with the controls(caudate nucleus: left(6.94 ±1.00)mm3, right (6.93 ±0.88)mm3;putamen:left(5.64 ±0.69)mm3,right(6.03 ±0.86)mm3;globus pallidus: left (3.49 ±0.26)mm3,right(3.60 ±0.25)mm3,PD patients(caudate nucleus:left(5.99 ±1.78)mm3, right(6.11 ±1.65)mm3;putamen:left(4.99 ±1.50)mm3,right(5.56 ±1.68)mm3;globus pallidus:left(3.12 ±0.72)mm3,right(3.23 ±0.72)mm3)exhibited volume reduced in bilateral caudate nuclei(left t=2.871, P=0.005;right t=3.045, P=0.003), left putamen(t=2.773, P=0.007), and bilateral globus pallidus(left t=3.439, P=0.001; right t=3.493, P=0.001).Early stage of PD patients exhibited these changes.In addition,atrophy was showed mainly in left putamen(t=2.136, P=0.038)and globus pallidus(left t=2.683, P=0.010; right t=2.637, P=0.011)in the early stage, while in the later stage,caudate nucleus volume reduction(left t=3.260,P=0.002;right t=3.089,P=0.003)was also found.Moreover,no significant differences were found between tremor-dominant PD group and akinetic-rigid-dominant PD group.However, bilateral volume changes of basal ganglia in PD patients were not explicitly relevant to age,gender,Mini-Mental State Examination score,levodopa equivalent doses, disease duration,Hoehn-Yahr stages,Unified Parkinson's Disease Rating Scale-Ⅲ score, Hamilton Rating Scale for Depression score or Hamilton Rating Scale for Anxiety score.Conclusions The phenomenon of reduced basal ganglia volume was found in patients with PD.The measurement of basal ganglia volume by MRI could be an objective way for early diagnosis of PD.