Praziquantel is the only effective drug of choice against five huaman species of schistosomes. Main adva-ntages of praziquantel include convenient oral administration, high safety and efficacy as well as short treatment course. To better understand the mode of action of praziqantel against schistosomes would be helpful for further development of new broad-spectrum anthelminthics. This paper summarizes the 30 years′ research progress on the mode of action of the drug against schistosomes proceeded by domestic and abroad laboratories.

This paper summarizes the progress in the study on anthelmintics,including nematocide,trematocide and cestocide since the founding of the People′ s Republic of China and the roles that these agents played in the control of parasitic diseases.Meanwhile,views are given to the challenges faced in the further study on anthelmintics.

Objective To evaluate the health effects of ambient air pollution on the respiratory systems of school children and screen the risk factors associated with respiratory diseases in order to propose air pollution control measures and to protect susceptible population. Methods The air pollution monitoring data were obtained from the local environmental protection bureau. Six thousand elementary school pupils (grade 1 and grade 6, half girls and half boys) were selected from light and heavy air pollution areas. Respiratory health states were assessed by investigation of the children's respiratory symptoms and diseases using a parent-completed questionnaire. The results were analyzed by non-conditional logistic regression analysis to calculate ORs of respiratory symptoms and diseases and 95% confidence intervals, after adjustment for air pollution levels, age, sex, indoor coal-burning, parents' smoking, ventilation and parents' respiratory disease history. Results TSP in lightly and heavily air-polluted areas were 0.59 mg/m3 and 1.02 mg/m3 respectively (P

Physiological MR imaging techniques provide abundant information for the diagnosis and research of knee cartilage le -sions.It can not only evaluate the morphology and structure of cartilage , but also analyze the functional , metabolic and biochemical changes quantitatively , to explore the causes of cartilage lesions at the molecular level .Application and advance of physiological MR imaging of knee articular cartilage are reviewed , including sodium imaging , delayed gadolinium enhanced magnetic resonance imaging of cartilage, T1ρ, T2 mapping, chemical exchange saturation transfer , diffusion imaging and so on, aiming at providing references for choosing MR imaging of knee articular cartilage .

Objective To observe the efficacy and complication of laser subepithelial keratom ileusis (LASEK) combined with mitomycin C (MMC) in treatment of high myopia.Methods 118 cases ( 236 eyes) diagnosed as high myopia were treated by LASEK combined with MMC.The changes of vision,refractive regression,postoperation pain and haze were observed.Results 7-days after operation,all patients' post-operation relief.6-months after operation,the quantity of vision reached or exceeded BCVA were 228 cases ( 96.61％ ),average refraction wsa ( + 0.54 ± 0.24 ) D,the incidence of haze was 4.66％.Conclusion Is safe the LASEK combined with MMC in treatment of high myopia,effective,low incidence of haze.

More than 40 institutions have set up the specialty of medical law in order to train inter-disciplinary talents of medical law.Many scholars undertook extensive research aiming at strengthening and developing this new specialty,but many problems still existed in its teaching and the quality of the graduates was been questioned.Through in-depth analysis of the existing research,we pointed out three problems of the current research:being subjective and lacking data support; confining to the ivory tower and lacking contact with the social; limiting to scholars and teachers and lacking retrospective thinking and critique from postgraduates.

Objective To discuss the clinical curative effect on maxillary sinusitis nasal endoscopic single path surgical treatment and provide reference for the clinical treatment.Methods A total of 52 patients of fungal ball type maxillary sinusitis were randomly divided into group A(26 patients) and group B (26 patients).The patients in group A were treated by endoscopic single path surgical treatment and the patients in group B were treated by intranasal antrostomy.The clinical curative effect was analyzed.Results In group A and group B,the total effective rate was 88.5％(23/26) and 65.4％(17/26),there was significant difference (P ＜0.05).The remission rate of nasal obstruction,nasal discharge with suppuration,nasal discharge with blood,headache were 100.0％ (26/26),92.3 ％ (24/26),84.6％ (22/26),73.1％ (19/26) in group A,and 100.0％(26/26),88.5％(23/26),76.9％(20/26),65.4％(17/26) in group B.The recurrence rate in group A and group B was 0,15.4％(4/26),there was significant difference (P＜ 0.05).Conclusions The clinical curative effect of endoscopic single path surgical treatment is better,and the recurrence rate is lower.It is worthy of clinical application.

Objective To discuss the reliability of sensory integration curing and the affecting element of curing result. Method Adopt standardized curing method to 455 children, four to twelve years old, who have sensory integration disorder. Start up parents school as well. Result The total effective rate is 85%. The more parents grasp the children sanitation knowledge, the better results are. The better results are also related to the level of disorder, intelligence quotient, age and curing period. Conclusion Sensory integrating treatment is effective in treating sensory integrating disohter in children by systematic psychological intervention for children and personal psychological intervention for parents.

The academic thoughts of WU Pei-heng originate from the theory of emphasizing yang in Inner Canon of Huangdi and warming and assisting yang theory in Treatise on Cold Pathogenic Diseases,which inherits and develops the theorectical essence of ZHENG Qin-an.The core of WU Pei-heng’s academic thoughts is the importance of yang-qi in human body.In his opinion,yang-qi is the essence of human,warming yang is the basic principle and treatment in clinic,large dose of aconite root should be used to saving critical patient.In addition,two cases treated by warming yang method are recorded to verify the practicability of WU Pei-heng’s thoughts.

Experimental studies indicated that the killing process of schistosomes induced by praziquantel comprises two aspects, i.e. the direct effect of praziquantel on schistosomes and the host immune reaction. The former one appears in stimulation of worm activity, spasmodic contraction of worm musculatures and severe damage to the tegument, which results in hepatic shift of schistosomes, influence on the nutrition absorption, excretion/secretion and defense function of the tegument, followed by the secondary interference with the worm metabolism. While the latter one involves the destruction of the host concomitant immune mechanism after tegumental damage and peeling, which is unfavorable for worm survival. Particularly, the exposure of the worm surface antigen provides a target which can be attacked by specific antibodies. Therefore, the antischistosomal activity of praziquantel is immune-dependent. In this paper some host factors involved in the killing process of schistosomes induced by praziquantel were summarized.