Objective · To investigate the clinical effects of photo-activated disinfection (PAD)-assisted non-surgical therapy on the treatment of chronic periodontitis. Methods · Eleven patients with chronic periodontitis (totally 118 selected sites) were randomly enrolled. A split-mouth self-control method was adopted. Selected sites with the probing depth (PD) of bilateral homonymous teeth ≥ 5 mm were randomly assigned to the group A (receiving scaling and root planning, SRP) and the group B (receiving SRP+ PAD). Periodontal clinical indexes, inflammation indexes, and periodontal pathogens at selected sites were examined at baseline and 6 and 12 weeks after treatment. Results · Both SRP alone and SRP+PAD improved the periodontal inflammation significantly. The positive rate of bleeding on probing (BOP) 12 weeks after treatment was remarkably lower in the group B than in the group A (37.3% vs 57.6%, P=0.042). Both SRP and SRP+PAD effectively decreased matrix metalloproteinase-8 (MMP-8) and interleukin-1β (IL-1β) levels in gingival crevicular fluid. The IL-1β levels 6 and 12 weeks after treatment were significantly lower in the group B than in the group A [(17.99±14.26) pg/mL vs (32.64±30.69) pg/mL, P=0.007; (11.37±10.25) pg/mL vs (23.85±15.55) pg/mL, P=0.000]. Both treatments decreased the ratio of P. gingivalis and F.nucleatum in total bacteria. Conclusion · PAD can serve as a potential adjunctive therapy to conventional SRP in the treatment of chronic periodontitis with better improvement of bleeding gums and control of periodontal inflammation.

OBJECTIVE: To discuss the clinic effect and surgical experience of complicated deflection of nasal septum with endoscopic surgery. METHOD: Fifty-two patients with complicated deflection of nasal septum were diagnosed by nasal endoscopy and CT scan,such as posterior segment deflection, huge processus spinosus, multi-abnormal curvature, nasal septum fracture dislocation and second operation for deflection of nasal septum. All case were followed-up for six months, RESULT: All case had satisfactory surgical results. All had an unobstructed nasal cavity and no perforation of nasal septum, nasal synechia and bridge of nose collapsed. CONCLUSION Endoscopic surgery in complicated deflection of nasal septum have the good advantages of vision and accuracy. So the endoscopic surgery is a minimally invasive surgery and benefit to the nasal physiological function.
Adolescent ; Adult ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Nasal Septum ; abnormalities ; surgery ; Treatment Outcome ; Young Adult

Objective To investigate the effect of antihypertensive therapy on post-stroke depression （PSD） in patients with acute ischemic stroke. Methods A total of 83 patients who were diagnosed with ischemic stroke by computed tomography or brain magnetic resonance imaging within 48 hours after the appearance of symptoms from August 2020 to January 2022 were enrolled in this study， and they were divided into intensive antihypertensive therapy group （intensive group with 41 patients） and standard antihypertensive therapy group （standard group with 42 patients） using a random number table. The goal of the intensive group was to reduce systolic blood pressure to <130 mmHg， and the goal of the standard group was to reduce systolic blood pressure to <140 mmHg. The primary outcome was the incidence rate of PSD during follow-up for 6 months after treatment， which was defined as ≥8 points for Hamilton Rating Scale for Depression-24 Items （HRSD-24）， and secondary outcomes were cognitive tests ［Addenbrooke's Cognitive Examination Revised （ACE-R） and Stroop test］ and activities of daily living （Barthel Index）. The safety outcome was a serious adverse event. Results After 6 months of treatment， compared with the relative changes of systolic blood pressure and diastolic blood pressure in the standard group， the systolic blood pressure and diastolic blood pressure in the intensive group were reduced by 10.6 mmHg and 5.5 mmHg， respectively （P<0.001 and P=0.004）. In addition， the relative change of heart rate during treatment in the intensive group was reduced by 5.0 bmp compared with that in the standard group （P=0.034）. After adjustment for random variables， there was no significant difference in the primary outcome （HRSD score） between the intensive group and the standard group during the treatment period， and HRSD score in the intensive group was reduced by 1.2 （95%CI -0.8 to 1.1， P=0.105）. As for the secondary outcomes， compared with the standard group， the intensive group had significant reductions in ACE-R （P=0.045） and mRS （P=0.036） and significant increases in the scores of accuracy （P=0.027）， interference accuracy （P=0.033）， and animal naming （P=0.008） in Stroop test. There was no significant difference in the overall incidence rate of serious adverse events between the two groups at the end of the trial （χ2=0.597， P=0.440）. Conclusion Intensive antihypertensive therapy has an acceptable safety profile in patients with acute ischemic stroke， but it cannot reduce the risk of PSD.