Objective To investigate the curative effect of kelp micro gelation (KGM) for bronchi arterial chemoembolization (BACE) combined with radiofrequency ablation (RFA) for central lung cancer.Methods 60 patients pathologically confirmed as the central lung cancer were enrolled and performed with BACE+KGM after the tumor-feeding artery was confirmed.RFA was performed under local anesthesia 1 month later.1 month,3 months and 6 months after the treatments CT scan was performed to show the changes of the tumor.Tumor markers were detected by blood test 1 month before and after the treatments.Up to the end of this study.Improvements of clinical symptoms and complications were also evaluated.Results Among the 60 patients under the treatment of BACE+KMG+RFA,10 patients had a complete remission(CR),33 patients in partial remission (PR),11 patients in stable (SD) and 6 patients in progress (PD).1 month after the treatments,VEGFA,VEGFB,VEGFC,CEA,CA125 and CA19-9 were significantly decreased,with the overall reactive rate (ORR) of 71.67％,disease control rate (DCR) of 90.00％,18.33％ of no change,10.00 ％ progressing and the 2 year survival rate was 93.33 ％.Conclusion BACE+KMG combined RFA is an effective treatment for central lung cancer with better short-term and long-term effect,improving the life quality and survival time of patients significantly.