Objective To assess whether AECOPD patients can breathe independently at the PIC window and thus whether NPPV was necessary after extubation.Methods We performed a prospective observational study, we used the spontaneous breathing trial (SBT)to assess whether each patient could breathe independently at the PIC window,then performed extubation.Patients who passed the SBT received oxygen therapy only,whereas those who failed received NPPV.However,if the former showed respiratory distress,they also received NPPV.The primary out-come variables were SBT pass/fail,the demand for NPPV and rate of reintubation within 72h following extubation. Results In all,23 patients were enrolled,15cases(65.2%)of which passed the SBT.Of these,12cases (80.0%) patients developed respiratory distress after extubation and required NPPV (one of whom required reintubation).Of the eight patients that failed,one received reintubation after NPPV.The reintubation rates within 72h following extuba-tion of SBT-pass(7.0%)and SBT-fail (13.0%)(χ2 =1.476,P>0.05)patients were comparable.Conclusion Most AECOPD patients can breathe independently at the PIC window,but nonetheless develop respiratory distress and thus require NPPV following extubation.

Objective To investigate the effects of heparanase and E-cadherin on the invasion and metastasis of gastric cancer. Methods Fifty specimens of gastric cancer which had been resected at Cancer Hospital of Liaoning Province from February 2005 to May 2007 were collected. The expression of heparanase mRNA and E-cadherin mRNA in these gastric cancer specimens was detected by RT-PCR, and the expression of E-cadherin in these gastric cancer specimens was detected by immunohistochemistry. Data were analyzed by t-test and variance analysis, and the enumeration data analyzed by chi-square test. Results There were significant differences in the expression of heparanase and E-cadherin between gastric cancer cells with high and low differentiation, presence and absence of metastasis, and TNM stages Ⅰ and Ⅱ versus Ⅲ and Ⅳ (t = 1.999, 4.258, 1.735 ; 1.286, 6.794, 3.091; χ~2 =6.273, 9.397, 5.640, P <0.05). The co-expression of heparanase (+) and E-cadherin (-) was correlated with tumor undifferentiation, lymph node metastasis and advanced TNM staging (χ~2 =11.306, 10.208, 8.420, P <0.05). Conclusions Heparanasc shows high expression while E-cadherin shows low expression in gastric cancer tissue. There is a synergistic effect between the abnormal expression of heparanase and E-cadherin, and the gastric cancer cells with coexpression of heparanase and E-cadherin have more malignant potential.

Objective To explore the effects of continuing nursing health education on postoperative rehabilitation of patients with gastric cancer. Methods A total of 98 cases of patients with gastric cancer radical were selected from December 2011 to December 2012 in our hospital according to the random number table method and were divided into observation group and control group. The patients of control group were given routine nursing, while the patients of observation group were given continuity of nursing health education based on the control group. We evaluated self satisfaction after nursing intervention of pain control, and assessed the score of self-rating anxiety scale ( SAS) , self-rating depression scale ( SDS) and quality of life self-rating scale. Results After intervention in the intervention group, the patients′ satisfaction to pain control method, to pain control education and all care, and family satisfaction scores were (42. 15 ± 14. 21), (44. 26 ± 13. 2), (16.69 ±2.20), that all were higher than these of the control group (t=3. 658, 5. 698, 4. 265; P<0. 05). Before the implementation of continuity of nursing health education, two groups of patients with SAS scores and SDS scores and the patient′s appetite, sleep quality and mental status, level of understanding of cancer, family understanding and cooperation, and daily life six dimensions related to the pain and psychological differences had no statistical significance (P>0. 05);continuity of nursing health education after implementation, the SAS scores and SDS scores were (30. 58 ± 8. 64), (35. 21 ± 9. 02) in the observation group that all were obviously lower than these of the control group (t=2. 245, 2. 014;P<0. 05); after the intervention group in appetite, sleep quality and mental status, the understanding of cancer, family understanding and cooperation, the score in the daily life were (3. 52 ± 0. 78), (4. 36 ± 1. 25), (3. 92 ± 1. 14), (4. 25 ± 0. 42), (3. 78 ± 0. 87), (4. 21 ± 0. 62);in six dimensions, related to the pain and psychological in the observation group were better than those of the control group (t=3. 145, 2. 896, 3. 859, 5. 697, 4. 021, 4. 256; P<0. 05). Conclusions Continuity nursing health education can reduce gastric cancer patients with postoperative pain and the degree of anxiety and depression patients, improve the patient′s quality of life and is good for stomach cancer patients with postoperative recovery.

Objective:To explore the status of early social function in young and middle-aged patients after percutaneous coronary intervention (PCI) and analyze its influencing factors, so as to provide a basis for formulating relevant intervention measures.Methods:From July to December 2021, the convenient sampling method was used to select 110 young and middle-aged patients with coronary heart disease after PCI in the First Affiliated Hospital of Harbin Medical University as the research objects. The general information questionnaire, Social Disability Screening Schedule (SDSS) , Social Support Rate Scale (SSRS) and General Self-Efficacy Scale (GSES) were used to investigate the patients. Univariate analysis and multiple linear regression analysis were used to explore the influencing factors of early social function in young and middle-aged patients with coronary heart disease after PCI. A total of 110 questionnaires were distributed and 106 valid questionnaires were recovered, with an effective recovery rate of 96.36% (106/110) .Results:The scores of SDSS, SSRS and GSES of 106 young and middle-aged patients after PCI were (3.89±1.63) , (38.80±7.02) and (21.08±6.39) , respectively. The results of univariate analysis showed that there were statistically significant differences in SDSS scores among patients with different gender, family per capita monthly income, education level and number of stents ( P<0.01) . The results of multiple linear regression analysis showed that gender, family per capita monthly income, education level, number of stents, general self-efficacy and social support were the influencing factors of early social function in young and middle-aged patients with coronary heart disease after PCI ( P<0.05) . Conclusions:The status of early social function in young and middle-aged patients with coronary heart disease after PCI is not ideal. Medical staff should give more intervention and guidance to patients after PCI who are female, have a lower education level, have a lower per capita monthly family income and have a large number of stents, consider the influence of self-efficacy and social support on the social function of patients and formulate corresponding intervention measures according to the influencing factors, so as to improve the level of social function of patients.