Objective:To investigate the clinical efficacy of conversion therapy with XELOX regimen in the treatment of stage IV advanced gastric cancer.Methods:The diagnosis and treatment process of two patients with stage IV gastric cancer who were diagnosed and treated in Southern Central Hospital of Yunnan Province (The First People's Hospital of Honghe State) in September 2018 and July 2019 were retrospectively analyzed. The performance of conversion therapy with XELOX regimen in the treatment of stage IV gastric cancer was analyzed based on relevant literature.Results:Pathological complete remission of stage IV gastric cancer was achieved in both patients after conversion therapy with XELOX regimen.Conclusion:Conversion therapy with XELOX regimen is effective on stage IV gastric cancer and is worthy of clinical promotion.