1.The Observation of the Curative Effect of the Acute Pelvic Inflammatory Disease Using the Combination of Penyanjing Capsule And Miconazole
International Journal of Traditional Chinese Medicine 2009;31(3):246-
Objective To observe the curative effect of the acute pelvic inflammatory disease through the combination of Penyanjing capsule and Miconazole. Methods Grouping the research patients into two groups with 32 patients respectively:the control group was given the Miconazole and the treating group was given the combination of Penyanjing capsule and Miconazole.Results The research group had the total effective power 100% but the control group only had 62.5% and the difference had obvious significance.Conclusion The combination of Penyanjing capsule and Miconazole has conditioning effects to the acute pelvic inflammatory disease.
2.Analysis of key genes and targeted protection methods affecting the survival of human islets
Wanli LI ; Yingying ZHANG ; Ting ZHANG ; Yuwei YANG ; Shanshan GU ; Lingling WU ; Shuangqin CHEN ; Jibing CHEN ; Hongjun GAO
Organ Transplantation 2023;14(2):273-
Objective To identify the key genes and targeted protection methods affecting the survival of human islets. Methods Using bioinformatics method, the gene expression profile (GSE53454) was selected through screening and comparison from Gene Expression Omnibus(GEO) database. GEO2R tool was employed to screen the differentially expressed gene(DEG) between the human islets exposed (exposure group) and non-exposed (non-exposure group) to interleukin (IL)-1β and interferon (IFN)-γ for 24, 48 and 72 h, respectively. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by DAVID. Protein-protein interaction (PPI) network was constructed by STRING and Cytoscape apps. Results A total of 69 up-regulated DEGs and 2 down-regulated DEGs were identified. GO analysis showed that during the biological process, DEGs were enriched in the aspects of virus defense and inflammatory response. In cellular components, DEGs were significantly enriched in extracellular space, outside plasma membrane and extracellular regions. Regarding molecular functions, DEGs were significantly enriched in chemokine activity and cytokine activity. KEGG analysis revealed that DEGs were mainly enriched in multiple signaling pathways, such as cytokine-cytokine receptor interaction, virus protein-cytokine and cytokine-receptor interaction,
3. The effect of pre-pregnancy weight and the increase of gestational weight on fetal growth restriction: a cohort study
Mengyao SHI ; Yafei WANG ; Kun HUANG ; Shuangqin YAN ; Xing GE ; Maolin CHEN ; Jiahu HAO ; Shilu TONG ; Fangbiao TAO
Chinese Journal of Preventive Medicine 2017;51(12):1074-1078
Objective:
To investigate the effect of pre-pregnancy weight and the increase of gestational weight on fetal growth restriction.
Methods:
From May 2013 to September 2014, a total of 3 474 pregnant women who took their first antenatal care and willing to undergo their prenatal care and delivery in Ma 'anshan Maternity and Child Care Centers were recruited in the cohort study. Excluding subjects without weight data before delivery (
4.Sense of coherence in female empty nest elderly and its influence on health self-management skill
Shuangqin CHEN ; Aixia LI ; Jier SU
Chinese Journal of Practical Nursing 2018;34(25):1978-1982
Objective To explore the sense of coherence in female empty nest elderly and its influence on health self-management skill. Methods There were 124 female empty nest elderly collected from 2 communities in Beilun and Jiangbei District by convenience sampling between April and October 2017. The basic data questionnaire, Sense of Coherence-13 and Health Self-management Skill Scale for Adults were used to collect data. Results The score of sense of coherence was 57.64 ± 11.35, which was in the low level. The score of health self-management skill was 125.64±20.22, with the highest score in self-management cognition, lowest score in self-management behavior. The sense of coherence and comorbidity can influence the self-management behavior. The educational level, comorbidity and religion can influence the self-management cognition. The sense of coherence and live alone or not can influence the self-management environment. Conclusions Community workers should pay attention to the management of female empty nest elderly, expand their social contact, encourage and guide them to use all kinds of social resources to face the difficulties, improve the data for the elderly living alone, establish periodic condolences and follow-up system, and improve the health self-management skills.
5.A cohort study on the differences of developmental behavior between early term infants and full-term infants
Guopeng GAO ; Shuangqin YAN ; Tingting WENG ; Hui CAO ; Zhiling CAI ; Sumei WANG ; Maolin CHEN ; Jingfang CHEN ; Fangbiao TAO
Chinese Journal of Health Management 2020;14(6):541-544
Objective:To investigate the developmental behavior of early term infants at 6 months and its difference from that of complete full-term infants.Methods:A healthy maternal and infant birth cohort in maanshan city, established in Maanshan Maternal and Child Health Hospital from June 2015 to June 2016. Birth outcomes were copied from the hospital electronic medical record system after delivery. The Chinese Ages and Stages Questionnaires was used to assess developmental behavior. The chi-square test and multivariate unconditional logistic regression model were used to analyze the differences in the behavioral development of early and full term infants.Results:The birth rate of early term infants was 24.74% (500/2 021). The detection rates of communication, gross motor, fine motor, problem solving and individual-social areas in early term infants were 2.1%, 3.2%, 6.1%, 6.3% and 2.7%, respectively. The detection rate of problem-solving area in early term infants was significantly higher than that in the full-term infants (6.3% vs. 3.7%, χ 2=5.42, P<0.05). After controlling for confounding factors, compared with full-term infants, the risk of problem-solving area in early infants was significantly increased ( OR=1.65, 95%CI:1.01-2.70, P<0.05). Conclusion:The risk of behavioral retardation in Early term infants is significantly higher than that in full-term infants, and long-term follow-up and appropriate early development promotion interventions are needed to improve their quality of life.
6.Physical activity status of early stage pregnant women and its influential factors
Xiaomin JIA ; Shuangqin YAN ; Hui CAO ; Guopeng GAO ; Maolin CHEN ; Jingfang CHEN ; Yafei WANG ; Baoli ZHANG ; Fangbiao TAO
Chinese Journal of Health Management 2019;13(1):71-75
Objective To understand the physical activity of early stage pregnant women and explore its influential factors. Methods From June 2015 to June 2016, 2122 pregnant women with early pregnancy card in Ma An Shan Maternal and Child Health Hospital were selected and surveyed with a questionnaire. The Physical Activity Questionnaire was used to understand the physical activity of pregnant women in their early pregnancy. Analysis of variance and t-test were used to describe the distribution of energy expenditures of physical activity of pregnant women with different demographic characteristics, and multiple linear regression analysis was used to analyze the factors influencing the energy expenditure of their physical activity. Result The duration of activities of sleep and sitting type was (16.56 ± 3.54) h, accounting for 83.38%of total activity time;the energy consumption value was (17.17±5.59) METs·h;mild physical activity time was (2.62±1.86) h, accounting for total time. 13.19%and the energy consumption value was (6.06±4.43) METs·h;the average time of moderate to severe physical activity was (0.68±0.93) h, accounting for 3.42%of total physical activity time, and the energy consumption value was (3.22±4.58) METs·h. In the univariate analysis, the energy expenditures of physical activity between the different groups (t=-3.551), education level (F=1.347), and occupation type (F=1.485) were different, and the difference was statistically significant (P<0.05). In multiple linear regression analysis, different occupational types and education were the energy expenditure levels of physical activity during early pregnancy. Influencing factors (P<0.05). Conclusion Pregnant women have longer periods of sleep and meditation during the first trimester, and shorter duration of physical activity than mild and above;the energy expenditure of physical activity during the first trimester of pregnancy is affected by the occupational type and educational level of the pregnant woman.
7.Research progress of Traditional Chinese Medicine for the treatment of rhythm disorder of blood pressure
Shiwen ZHANG ; Haitao SHANG ; Xinxin PANG ; Chenhui WANG ; Mengyu LI ; Zhentao WANG ; Shuangqin CHEN
International Journal of Traditional Chinese Medicine 2023;45(3):376-380
Normal human blood pressure has a unique "dipper type" rhythm, but various pathological factors will lead to abnormal nighttime blood pressure decline, seriously damage the target organs such as the heart, brain and kidneys, and significantly increase the incidence of cardiovascular events. Therefore, it is necessary to pay sufficient attention to rhythm disorder of blood pressure and intervene early. Modern Traditional Chinese Medicine (TCM) mostly understands the changes of rhythm of blood pressure from the view of the unity of nature and man, yin-yang theory and the theory of meridian flow, and study the syndrome distribution and TCM constitution law of rhythm disorder of blood pressure by combining TCM syndrome differentiation method and TCM constitution theory. TCM treatment can restore blood pressure rhythm and improve clinical symptoms and sleep quality of patients.
8.Analysis on the correlation between serum 25(OH)D deficiency and pregnancy-related anxiety in early pregnancy
Cheng WEI ; Xiaowu HU ; Shuangqin YAN ; Hui CAO ; Xiaomin JIA ; Maolin CHEN ; Yafei WANG ; Baoli ZHANG ; Yan HAN ; Fangbiao LANLAN ; Tao FENG
Chinese Journal of Health Management 2017;11(6):548-552
Objective To explore the correlation between pregnancy-related anxiety and serum 25 (OH)D level during early pregnancy. Methods A radioimmunoassay was used to determine the serum 25 (OH)D levels of 2 122 early pregnant women in Maanshan Maternal and Child Health Care Hospital, from June 2015 to 2016. Data were collected using a questionnaire. Results The mean serum 25(OH)D level was(29.71±32.27)nmol/L.About 15.2% of the subjects had adequate,22.6% had insufficient,45.1% had deficient,and 17.1% had severely deficient serum 25(OH)D levels.The type of housing and testing seasons were significantly associated with the serum 25(OH)D level.Single factor logistic regression analysis results show that pregnancy-related anxiety incidence in the group deficient in 25(OH)D was higher than that in the adequate group, which has a statistically significant difference (P<0.05). After adjusting for the maternal age,BMI,and educational level,multivariate logistic regression analysis results showed that the difference was statistically significant. Conclusion The serum 25(OH)D level in early pregnant women was inadequate. Furthermore, lack of serum 25(OH)D in early pregnancy and pregnancy-related anxiety were negatively correlated.
9.Study on the age composition of blood donors in some areas of China
Yuxiang CHEN ; Dongyan ZHAO ; Ling HOU ; Nan ZHAO ; Jing XU ; Xiaohua YUAN ; Xinyi TANG ; Dengping LEI ; Guiqi ZHAO ; Ying LI ; Yifei WANG ; Dan LIU ; Dong LI ; Can HUANG ; Lin WANG ; Yang ZHANG ; Xia DU ; Bin JU ; Shuangqin LI ; Shuanglin XUE ; Xiaojuan WU ; Jiangeng ZHANG ; Wusheng LI
Chinese Journal of Blood Transfusion 2022;35(4):368-371
【Objective】 To explore the recruitment and retention strategy of blood donors by investigating the age composition of blood donors in some areas of China, so as to promote blood donation and enhance clinical blood supply. 【Methods】 Through the working platform of Practice Comparison Working Group of China’s Mainland Blood Collection and Supply Institutions, the average age and age composition of blood donors from 22 blood centers were collected, and statistical analysis was conducted after eliminating invalid data. 【Results】 The median average age of blood donors during the survey year was 30.02.The median age in 2.89% of the blood centers was lower than 25. The average age of different genders was statistically significant only in 2018(P<0.05). Fot first-time blood donors, the median constituent ratio of donors <25 and ≥25 years old was 54.53% and 44.28%, with median retention rate at 10.30% and 9.61%, respectively. The median overall participation rate of blood donors was 2.7%, with median participation rate of blood donors <25 years old at 5.1%. 【Conclusion】 The recruitment and retention of blood donor is crucial to enhance clinical blood supply. Blood donors <25 years old, with a longer period for future donation, should be the main target of blood donation recruitment. Meanwhile, the revision of upper age limit for blood donation is another important initiative to grow the blood donor pool.
10.Mid-gestational glucose levels and newborn birth weight: birth cohort study.
Sanhuan HUANG ; Yeqing XU ; Maolin CHEN ; Kun HUANG ; Weijun PAN ; Xing GE ; Shuangqin YAN ; Leijing MAO ; Ying NIU ; Shilu TONG ; Fangbiao TAO
Chinese Journal of Epidemiology 2016;37(1):45-49
OBJECTIVETo understand the association between the blood glucose levels of pregnant women in second trimester detected by 75 gram oral glucose tolerance test (OGTT) and the birth weight of neonates.
METHODSDemographic information collection and OGTT were conducted for 3 081 pregnant women at ≤14 gestational weeks and 24-28 gestational weeks respectively. Multiple logistic regression analysis was done to identify the factors associated with the birth weight and the risks of large for gestational age (LGA) in three levels (FPG, OGTT-1 h and OGTT-2 h) of OGTT percentile group, multiple linear regression analysis was used to evaluate the relationships between maternal glucose levels and neonate birth weight.
RESULTSPre-pregnancy obesity (24.0 kg/m2≤BMI<28.0 kg/m2) (OR=1.4, 95%CI:1.0-2.0, P=0.029) and gestational diabetes mellitus (OR=2.4,95% CI: 1.8-3.2, P<0.001) were the risk factors. Pre-pregnancy underweight (BMI<18.5 kg/m2) (OR=1.6, 95%CI: 1.2-2.2, P=0.003), preeclampsia (OR=4.0, 95%CI: 1.9-8.4, P<0.001) increased the risk for small for gestational age (SGA). Multiple linear regression analysis showed neonate birth weight was positive correlated with maternal glucose levels (β were 91.99, 33.60, 32.00, respectively, P<0.001). Percentile groups of each OGTT level was linearly positive associated with increased mean value of neonate birth weight, and so with the risk of LGA.
CONCLUSIONSThere were positive correlations between maternal glucose levels and neonate birth weight. The risk of LGA increased with the maternal glucose levels, but there was no statistical association between SGA and maternal glucose levels. FPG level is one of the predictors of LGA. Active surveillance and control of maternal glucose level can effectively reduce the risk of LGA.
Birth Weight ; Blood Glucose ; analysis ; Cohort Studies ; Diabetes, Gestational ; Female ; Glucose Tolerance Test ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Logistic Models ; Obesity ; Pre-Eclampsia ; Pregnancy ; Pregnancy Trimester, Second ; blood ; Risk Factors ; Thinness