[Objective] To investigate the improvement of abdominal symptoms,quality of life,and depression of Soothing Liver Regulating Qi and Regulating Spirit and Relieving Depression massage combined with western medicine treating diarrhea type irritable bowel syndrome(IBS) patients.[Methods] From January 2015 to December 2016,a total of 60 diarrhea type IBS patients were randomly divided into control group and treatment group.The control group was treated with Trimebutine Maleate Dispersible Tablets,while the treatment group was treated with Soothing Liver Regulating Qi and Regulating Spirit and Relieving Depression massage on the base of the control group.Two groups patients were treated for 4 weeks.The abdominal symptoms,quality of life,depression and serum 5-HT were collected before and after treatment.[Result] After 4 weeks treatment,the abdominal pain/abdominal discomfort,diarrhea,HAMD of both groups were lower than before treatment,and the treatment group was lower than the control group(P＜0.05).The SF-36 of both groups were higher than before treatment,and the treatment group was higher than the control group(P＜0.05).Serum 5-HT of both groups were lower than before treatment,and the treatment group was lower than the control group(P＜0.05).[Conclusion] Soothing Liver Regulating Qi and Regulating Spirit and Relieving Depression massage combined with western medicine can effectively improve the abdominal symptoms and quality of life for diarrhea type IBS patients.