OBJECTIVETo study the effect of Suxiao Jiuxinwan on angiogenesis in experimental myocardial infarction rats.

METHODThe animal model was established by ligation of anterior decending coronary artery and the infarction areas as well as microvascular density (MVD) in the marginal infarction area of the myocardial infarction rats were observed.

RESULTInfarction areas in high dose and low dose Suxiao Jiuxinwan groups were significantly different from that of model group (P<0.01), and this effect was similar with the positive model group and had the dosage-dependent speciality. The microvascular density (MVD) of marginal infarction areas in Suxiao Jiuxinwan high and low groups was much more elevated than that in the sham group (P<0.05), and the effect of Suxiao Jiuxinwan high group was similar with that of the positive control group. But the difference between the Suxiao Jiuxinwan high and the low goups was not significant.

CONCLUSIONSuxiao Jiuxinwan has the obvious effcet on angiogenesis in eperimental myocardial infarction rats.

Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Male ; Microvessels ; drug effects ; physiopathology ; Myocardial Infarction ; drug therapy ; physiopathology ; Neovascularization, Pathologic ; drug therapy ; Rats