Objective To explore the mediating effect of overgeneral autobiographical memory between shame and depression in college students.Methods Randomly selected 205 undergraduates were tested using Shame Scale (SS),the Center for Epidemiologic Studies Depression Scale (CES-D) and the Autobiographical Memory Test(AMT).Results (1) The total score of shame was (58.46± 12.34).The total score of overgeneral autobiographical memory was (5.19 ± 2.1 1).The total score of depression was (19.62±5.36).The correlation results showed that the sense of shame,the overgeneral autobiographical memory and depression were positively correlated with each other(r=1.99,0.48,0.28;all P＜0.01).(2)Mediation effect analysis and further Boot-strap test showed that sense of shame positively predicted depression,and overgeneral autobiographical memory partly mediated the association between the shame and depression,accounting for 10％ of total effect.Conclusion During the clinical treatment of depression,medical profession can reduce the depression caused by shame by intervening in the generalization of autobiographical memory of patients with depression.