Bronchopulmonary dysplasia(BPD)is a common disease in preterm infants, with high disability rate and morbidity.Current researches on biomarkers of BPD mainly focus on genes, inflammatory factors and cytokines, aiming to improve the prognosis of the disease.Metabolomics analysis can identify changes of the metabolites caused by the interaction between gene expression and environment.It contributes to evaluating the comprehensive pathophysiological process of BPD, such as oxidative stress, pulmonary surfactant and microbial colonization, so that can early detect the disease.This article reviews the lately metabolomic studies on screening new biomarkers of BPD.

Objective To find out the clinical characteristics and morbility factors of intravascular catheterrelated bloodstream infection(CRBSI). Methods Totally 21 patients who had CRBSI in neonatal intensive care unit were investigated retrospectively. Results The distribution of CRBSI was higher in very low birthweight preterm infants, gestational age among 28 ～34week, whose intravascular catheter remaining time were obove three weeks. Principal clinical presentation of CRBSI were poor feeding, unaocountable tachycardia, temperature instability, stressed hyperglycemia,refractoriness metabolic acidosis. The most common pathogens were coagulase-negative staphylococci (35.7%), Klebsiella pneumonia, bacilli ( 11.9% ) Staphylococcus aureus (9.5 % ), Pseudomonas aeruginosa( 7. 1% )and Enterobacter cloacae(7.1% ). Conclusions The clinical manifestations of CRBSI were concealment,and reducing the time of inserted central catherization and total parenteral nutrition, strengthening the nutrition of body would provide effective prevention of CRBSI.