It is necessary to refresh our understanding of the academic mission for information retrieval course in the network information era.The correlation between scientific achievements and scientific information and between scientific literacy and information literacy revealed the fact that information retrieval capability is the core of information literacy when the information retrieval course is placed a broader academic background.The connotation of information retrieval was elaborated, which further demonstrates that the academic mission for information retrieval course is to train the information wisdom of undergraduates.

The standard of Pharmaceutical packaging materials is an important part of the Chinese Pharmacopoeia. This article focuses on working background, general idea, working process, main framework, and its role and significance of the pharmaceutical packaging materials standards system in the Chinese Pharmacopoeia 2025 Edition, which can contribute to accurately understand and utilize the standards in the Chinese Pharmacopoeia 2025 Edition.

Objective To investigate the current situation and influencing factors of nursing satisfaction in general hospital of Changchun city, so as to explore the effective measures to improve the inpatient care satisfaction.Methods A stratified random sampling method was used to study the satisfaction of nursing services of 280 hospitalized patients in three general hospitals, which mainly included the basic information of the patients and their satisfaction to nursing service.Results The overall satisfaction of patients to nursing service was 90.4%,of which the gender, age, monthly income were the influencing factors.On the analysis of each item, the three highest satisfactory items were respecting the privacy of patients (96.4%), the nurses’ appearance (95.7%), and detecting and dealing with changes in condition (94.6%).The three lowest items were ward environment and hospital facilities (73.6%), access to disease-related knowledge (75.7%), and the nurse reminded all kinds of attentions after admission (77.9%).Conclusions Based on the patients’ satisfaction, we should take targeted measures to improve the hospital environment facilities and infrastructure, and strengthen the capacity of nursing services and health education capacity.

Objective To probe into the current status and influencing factors of sub-health among nurses in class A grade three hospitals in Changchun, and explore the strategies and corresponding measures for preventing nurses′sub-health. Methods A total of 500 nurses were chosen from June to August 2014 by cluster methods and investigated their basic information and status of sub-health in 4 class A grade three hospitals in Changchun. Results Ultimate 416 people completed questionnaires. A total 74. 6% of 416 investigators had sub-health, and the highest self assessment score for nurses was social sub-health (28. 35 ± 4. 55), the lowest one physiology sub-health (25. 57 ± 5. 16). The times of excise each week and the amount of water in-taking each day were important protective factors from sub-health, but the length of working experience as nurse, occupational title, life stress, family stress, degree of tense relationship with colleagues and work overtime were risk factors. Conclusions Nursing staffs maintain a high level of sub-health in Changchun class A grade three hospitals, which indicates the status of nursing staffs is pessimistic for their healthy status. Hospital administrators should make corresponding measures to prevent the sub-health of nursing staffs.

Objective:Gastrointestinal heat retention syndrome (GHRS) is associated with lung-heat syndrome and is related to recurrent respiratory infection.Upper respiratory tract infection (URTI) lung heat syndrome is common in children.The study will explore the effect of GHRS on the structure and function of gut microbiota in children with URTI lung-heat syndrome.Methods:Participants were divided into both groups using the self-developed URTI scale and the "GHRS Diagnostic Scale · Pediatric Part":GHRS-positive children (LS group) and GHRS-negative children (L group).General information,clinical symptoms,and stool were collected.We used 16S rRNA amplicon sequencing technology to determine the gene sequence of the V3-V4 region in feces and measure the gut microbiota of the both groups at the genus level.Results:A total of 23 children were included in the both groups.There were 12 cases in the LS group and 11 cases in the L group.There was no statistical difference between the both groups in age,gender,height,weight,and body mass index.The effective sequences shared by the both groups accounted for 85.66％ of the total.In the gut microbiota,there was no difference in the α diversity and the β diversity between the both groups.Compared with the L group,the LS group had a significant increase in the relative abundance of the Rurninococcus gnavus group,Prevotella-9,Staphylococcus,and Actinomyces(P ＜.05).The functions of the both groups of microbiota primarily concentrate on metabolism,genetic information processing,and environmental information processing.The relative abundance of signaling molecules and interactions in the LS group were higher than that in the L group (P ＜.05).The redun-dancy analysis (RDA) showed that the URTI score had the greatest impact on the distribution of microbiota.Conclusion:GHRS may affect the development of URTI lung-heat syndrome by changing the relative abundances of gut microbiota.

Objective To investigate influencing factors of clinical nurses working for aged nursing basing on theory of planned behavior(TPB), so as to provide reference for motivating nurses to work on aged nursing, and to predict possibilities of clinical nurses to work on the industry of aged nursing. Methods Questionnaire scale was designed basing on TPB and characteristics of aged nursing industry, and was handed out to 172 nurse practitioners in 4 hospitals in a city of Sichuan. Results Determination coefficients of attitude towards the behavior, subjective norm, and perceived behavioral control of clinical nurses′intention to work on aged nursing industry, R2 were respectively 0. 32,0. 45 and 0. 01. Determination coefficient of attitude towards the behavior, subjective norm, and perceived behavioral control of nurses′intention to work on aged nursing, was R2 =0. 36 (P<0. 05). Conclusions Subjective norm has the most remarkable influences on nurses′intention to work on aged nursing industry, followed by attitude towards the behavior, with the least of perceived behavioral control;it is feasible to apply TPB in exploring influencing factors for clinical nurses working on aged nursing.

Objective To evaluate the efficacy of oxycodone mixed with dexmedetomidine for patient-controlled intravenous analgesia (PCIA) after renal transplantation.Methods Sixty American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients of both sexes,aged 28-51 yr,weighing 53-76kg,scheduled for elective allografl renal transplantation under general anesthesia,were divided into 2 groups (n=30 each) using a random number table:oxycodone group (group O) and oxycodone mixed with dexmedetomidine group (group OD).PCIA was carried out at the end of surgery.PCIA solution contained oxycodone 1.0 mg/kg and tropisetron 5 mg in 100 ml of normal saline in group O and oxycodone 0.6 mg/kg,dexmedetomidine 5 μg/kg and tropisetron 5 mg in 100 ml of normal saline in group OD.PCIA pump was programmed to deliver 0.5 ml with a lockout interval of 15 min and background infusion at 2 ml/h,maintaining visual analog scale scores ≤ 4.When visual analog scale scores ＞4,oxycodone 0.05 mg/kg was intravenously injected as rescue analgesic.At 10 min before anesthesia and 4,12,24 and 48 h after operation,venous blood samples were collected for determination of plasma endothelin,blood urea nitrogen and creatinine concentrations (radio-immunity method) and epinephrine and norepinephrine concentrations in plasma (by high-performance liquid chromatography-electrochemical detection assay).The urine volume was recorded at each time point after the operation.The effective pressing times of PCIA and requirement for rescue analgesic were recorded within 48 h after operation,and the rate of rescue analgesia was calculated.The occurrence of adverse reactions such as over-sedation,nausea,vomiting,dizziness,respiratory depression and catheter-related bladder irritation symptoms was recorded within 48 h after operation.Parent's satisfaction with analgesia was assessed within 72 h after operation.Results Compared with group O,the concentrations of endothelin,blood urea nitrogen,creatinine concentrations,epinephrine and norepinephrine in plasma were significantly decreased,and the urine volume was increased at 12,24 and 48 h after operation,the rate of rescue analgesia was decreased,the effective pressing times of PCIA were reduced,the degree of parent's satisfaction with analgesia was increased,and the incidence of nausea and vomiting was decreased in group OD (P＜0.05).Conclusion Oxycodone mixed with dexmedetomidine produces better efficacy than either alone when used for PCIA after renal transplantation.

OBJECTIVE： To investigate the status of sulfur fumigation of TCM and its decoction pieces， and to put forward the suggestions on limit standard of sulfur dioxide residue. METHODS： The information of 374 varieties of TCM and sulfur dioxide residue were collected from the provincial and municipal drug inspection institutions of 27 provinces，municipalities and autonomous regions in China during 2013-2017， and then summarized and analyzed. The average value，median value，maximum value，qualification rate and detection rate of sulfur dioxide residue of 121 varieties with the sample number ≥10 batches were classified and statistically analyzed. RESULTS： This investigation involved 374 varieties of TCM and its decoction pieces， and a total of 13 776 batches of samples. The average content of sulfur dioxide was 242 mg/kg，the median value was 27 mg/kg，and the maximum value was 8 782 mg/kg. The overall qualified rate was 79.7％. According to the results of classified statistics， among the 10 varieties whose limit shall not exceed 400 mg/kg，5 varieties，including Codonopsis pilosula， Radix Trichosanthis， Asparagus cochinchinensis， Pueraria lobata， Achyranthes bidentata， were seriously affected by sulfur fumigation，and the qualified rate was less than 80％. Among the varieties with the sample number≥30 batches， there was no or very little abuse of sulfur fumigation in 16 varieties， such as Carthamus tinctorius； 19 varieties， such as Eupolyphaga Steleophaga， had excessive sulfur fumigation， but it was not serious； 25 varieties，such as Lonicera japonica，had severe excessive sulfur fumigation. Among the varieties with the sample number of 10-29 batches，33 varieties including Ziziphus jujube seed had no or very little abuse of sulfur fumigation； 8 varieties including Cuscuta chinensis had excessive sulfur fumigation but were not serious； 10 varieties including Pericarpium Trichosanthis had serious excessive sulfur fumigation. CONCLUSIONS： For the varieties with no or very little excessive sulfur fumigation，it is recommended that batch testing should not be carried out and a single list should be made； for the varieties with sulfur fumigation or severe sulfur fumigation， it is suggested to increase the sulfur dioxide residue limit under all varieties in the 2020 edition of Chinese Pharmacopoeia， and set the limit for the varieties with severe sulfur fumigation to be no more than 400 mg/kg，while the limit for the 2025 edition of Chinese Pharmacopoeia can be reduced to no more than 150 mg/kg. Other varieties should retain the provisions of “sulfur dioxide residue of sulfur dioxide medicinal materials and decoction pieces （except for minerals） shall not exceed 150 mg/kg” in the general rules 0212 “for the identification of medicinal materials and decoction pieces” in the 2015 edition of Chinese Pharmacopoeia （part Ⅳ）.

Objective To investigate the role of sodium-glucose cotransporter 1(SGLT1)inhibitor mizagliflozin(MIZA)in autosomal dominant polycystic kidney disease(ADPKD).Methods Western blotting,quantitative polymerase chain reaction(qPCR),and immunofluorescence staining were used to determine the expression and distribution of SGLT1 in kidney tissues of PKD1-/-and PKD1+/+mice,human renal cancer adjacent tissue and ADPKD tissue.Renal cyst lining epithelial cells OX161 and renal tubular epithelial cells UCL93 were treated with MIZA,incubated at 37℃for 24,48,and 72 h,and then were subjected to methyl thiazolyl tetrazolium and colony formation assay to observe cell proliferation.The qPCR method was used to determine the mRNA levels of collagen 1α1,collagen 3α1,and fibronectin 1 in OX161 cells treated with 100 μmol/L MIZA for 48 h.The Madin-Darby canine kidney(MDCK)cell 3D cyst formation assay verified the effect of MIZA on cyst formation.The mRNA-seq technology was used to detect differentially expressed genes between UCL93 cells and OX161 cells,and between OX161 cells and OX161 cells treated with 100 μmol/L MIZA for 48 h,and then the differentially expressed genes were analyzed with Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.Results The expression level of SGLT1 was significantly increased in the tissues of ADPKD patients and PKD1-/-mice compared to those in normal kidney tissues(P＜0.05,P＜0.01).Immunofluorescence staining revealed that SGLT1 was mainly expressed in the cystic lining epithelial cells.Additionally,MIZA inhibited the proliferation and fibrosis of polycystic kidney cells in a concentration-and time-dependent manner,and also inhibited cyst formation in 3D formation assay in vitro.The mRNA-seq analysis and KEGG enrichment analysis showed that differentially expressed genes between OX161 cells and OX161 cells cultured in 100 μmol/L MIZA for 48 h were mainly enriched in the phosphatidylinositol 3-kinase(PI3K)-protein kinase B(Akt)and mitogen-activated protein kinase(MAPK)signaling pathways,which were the same as those between OX161 cells and UCL93 cells.Conclusion The SGLT1 inhibitor MIZA may inhibit the proliferation and fibrosis of polycystic kidney cells through signaling pathways such as PI3K-Akt and MAPK,delaying the growth of polycystic kidney,and it is a potential therapeutic target for ADPKD.