It is necessary to refresh our understanding of the academic mission for information retrieval course in the network information era.The correlation between scientific achievements and scientific information and between scientific literacy and information literacy revealed the fact that information retrieval capability is the core of information literacy when the information retrieval course is placed a broader academic background.The connotation of information retrieval was elaborated, which further demonstrates that the academic mission for information retrieval course is to train the information wisdom of undergraduates.

Objective To evaluate the efficacy of oxycodone mixed with dexmedetomidine for patient-controlled intravenous analgesia (PCIA) after renal transplantation.Methods Sixty American Society of Anesthesiologists physical status Ⅱ or Ⅲ patients of both sexes,aged 28-51 yr,weighing 53-76kg,scheduled for elective allografl renal transplantation under general anesthesia,were divided into 2 groups (n=30 each) using a random number table:oxycodone group (group O) and oxycodone mixed with dexmedetomidine group (group OD).PCIA was carried out at the end of surgery.PCIA solution contained oxycodone 1.0 mg/kg and tropisetron 5 mg in 100 ml of normal saline in group O and oxycodone 0.6 mg/kg,dexmedetomidine 5 μg/kg and tropisetron 5 mg in 100 ml of normal saline in group OD.PCIA pump was programmed to deliver 0.5 ml with a lockout interval of 15 min and background infusion at 2 ml/h,maintaining visual analog scale scores ≤ 4.When visual analog scale scores ＞4,oxycodone 0.05 mg/kg was intravenously injected as rescue analgesic.At 10 min before anesthesia and 4,12,24 and 48 h after operation,venous blood samples were collected for determination of plasma endothelin,blood urea nitrogen and creatinine concentrations (radio-immunity method) and epinephrine and norepinephrine concentrations in plasma (by high-performance liquid chromatography-electrochemical detection assay).The urine volume was recorded at each time point after the operation.The effective pressing times of PCIA and requirement for rescue analgesic were recorded within 48 h after operation,and the rate of rescue analgesia was calculated.The occurrence of adverse reactions such as over-sedation,nausea,vomiting,dizziness,respiratory depression and catheter-related bladder irritation symptoms was recorded within 48 h after operation.Parent's satisfaction with analgesia was assessed within 72 h after operation.Results Compared with group O,the concentrations of endothelin,blood urea nitrogen,creatinine concentrations,epinephrine and norepinephrine in plasma were significantly decreased,and the urine volume was increased at 12,24 and 48 h after operation,the rate of rescue analgesia was decreased,the effective pressing times of PCIA were reduced,the degree of parent's satisfaction with analgesia was increased,and the incidence of nausea and vomiting was decreased in group OD (P＜0.05).Conclusion Oxycodone mixed with dexmedetomidine produces better efficacy than either alone when used for PCIA after renal transplantation.

OBJECTIVE： To investigate the status of sulfur fumigation of TCM and its decoction pieces， and to put forward the suggestions on limit standard of sulfur dioxide residue. METHODS： The information of 374 varieties of TCM and sulfur dioxide residue were collected from the provincial and municipal drug inspection institutions of 27 provinces，municipalities and autonomous regions in China during 2013-2017， and then summarized and analyzed. The average value，median value，maximum value，qualification rate and detection rate of sulfur dioxide residue of 121 varieties with the sample number ≥10 batches were classified and statistically analyzed. RESULTS： This investigation involved 374 varieties of TCM and its decoction pieces， and a total of 13 776 batches of samples. The average content of sulfur dioxide was 242 mg/kg，the median value was 27 mg/kg，and the maximum value was 8 782 mg/kg. The overall qualified rate was 79.7％. According to the results of classified statistics， among the 10 varieties whose limit shall not exceed 400 mg/kg，5 varieties，including Codonopsis pilosula， Radix Trichosanthis， Asparagus cochinchinensis， Pueraria lobata， Achyranthes bidentata， were seriously affected by sulfur fumigation，and the qualified rate was less than 80％. Among the varieties with the sample number≥30 batches， there was no or very little abuse of sulfur fumigation in 16 varieties， such as Carthamus tinctorius； 19 varieties， such as Eupolyphaga Steleophaga， had excessive sulfur fumigation， but it was not serious； 25 varieties，such as Lonicera japonica，had severe excessive sulfur fumigation. Among the varieties with the sample number of 10-29 batches，33 varieties including Ziziphus jujube seed had no or very little abuse of sulfur fumigation； 8 varieties including Cuscuta chinensis had excessive sulfur fumigation but were not serious； 10 varieties including Pericarpium Trichosanthis had serious excessive sulfur fumigation. CONCLUSIONS： For the varieties with no or very little excessive sulfur fumigation，it is recommended that batch testing should not be carried out and a single list should be made； for the varieties with sulfur fumigation or severe sulfur fumigation， it is suggested to increase the sulfur dioxide residue limit under all varieties in the 2020 edition of Chinese Pharmacopoeia， and set the limit for the varieties with severe sulfur fumigation to be no more than 400 mg/kg，while the limit for the 2025 edition of Chinese Pharmacopoeia can be reduced to no more than 150 mg/kg. Other varieties should retain the provisions of “sulfur dioxide residue of sulfur dioxide medicinal materials and decoction pieces （except for minerals） shall not exceed 150 mg/kg” in the general rules 0212 “for the identification of medicinal materials and decoction pieces” in the 2015 edition of Chinese Pharmacopoeia （part Ⅳ）.