Objective:To explore the related factors affecting the extravasation of CT enhanced high-pressure injection, and propose protective countermeasures for early warning intervention.Methods:From April to October 2019, 31 595 patients undergoing CT enhanced examination in the First Affiliated Hospital of Zhengzhou University were selected as the research subject. Patients were divided into extravasation group ( n=21) and no extravasation group ( n=31 574) according to whether they had extravasation of high-pressure injection. We collected clinical data and analyzed the related factors of extravasation of CT-enhanced high-pressure injection. Results:Among 31 595 patients undergoing CT enhanced examination, there were 21 cases with high-pressure injection extravasation, accounting for 0.07%. Univariate analysis showed that there was a statistical difference in the age, injection rate, contrast agent concentration, osmotic pressure, history of chemotherapy and working years of injection nurses between extravasation group and no extravasation group ( P<0.05) . Multivariate Logistic regression analysis showed that patient age, injection rate, contrast agent concentration, osmotic pressure, history of chemotherapy, and working years of injection nurses were related factors that affected the extravasation of CT enhanced high-pressure injection with a statistical difference ( P<0.05) . Conclusions:Related factors that affect CT enhanced high-pressure injection extravasation include patient age, disease type, injection rate, contrast agent concentration, osmotic pressure, working years of injection nurses, and history of chemotherapy.Taking active protective measures is of great significance to reduce the extravasation of contrast agent and the suffering of patients.