1.Prevention and Treatment of Radiation-Induced Pulmonary Fibrosis by the Method of Dispelling Stasis to Promote Regeneration
Lanxin ZHANG ; Shuaihang HU ; Jiawei WANG ; Tong ZHOU ; Wei HOU
Journal of Traditional Chinese Medicine 2024;65(10):1077-1081
Blood stasis is an important pathological factor throughout the whole course of radiation-induced pulmonary fibrosis, which could evolve from new into long stagnation, and the methods of dispelling stasis to promote regeneration should throughout the whole disease progress. It is believed that the basis of the radiation-induced pulmonary fibrosis is heat toxin dispersing qi and yin, and deficiency of healthy qi promoting blood stasis. The process of the disease showed latent fire burning pulmonary collaterals, and the binding of phlegm and stasis. The key factors of the disease were the damage of ying-wei (营卫) qi in channels and collaterals, as well as the blood stasis evolving into dried blood. It is suggested that during radiotherapy, we should pay more attention to relieve heat, moisten dryness, supplement qi and yin, nourish and harmonize blood, and remove blood stasis, so as to prevent disease before it arises. If there is radiation pneumonia, we could focus on dissolving phlegm, removing blood stasis, clearing latent fire, and unblocking the collaterals and veins, in order to "control the development of existing disease". If it develops into radiation-induced pulmonary fibrosis, we could relive the center and supplement deficiency, tonify original qi, dispel stasis to promote regeneration, and clear dried blood, for the purpose of slowing the progression of disease. These ideas might provide reference for clinical treatment.
2.Antibody identification and analysis of 80 children with positive platelet antibody in initial screening
Xiaohuan WANG ; Xiaoyan FU ; Yu LIU ; Shuaihang ZHANG ; Shuxuan MA
Chinese Journal of Blood Transfusion 2024;37(7):785-789
【Objective】 To explore the distribution and types of platelet antibodies in children with positive platelet antibody in initial screening. 【Methods】 Blood samples of 80 pediatric patients who applied for platelet transfusion in our hospital from September 2021 to May 2022 and tested positive for platelet antibodies were identified using the PAKPLUS kit for antibody identification, and the distribution of HLA and HPA antibodies were analyzed. 【Results】 Among the 80 reactive samples in initial screening, 9 were negative, 71 were positive. Among the 71 positive cases, 1 was HLA-Ⅰantibody positive(1.41%, 1/71), 21 were HPA antibody positive (29.58%, 21/71), and 49 were both HLA-Ⅰ antibody and HPA antibody positive(69.01%, 49/71). Among the 70 HPA positive cases, 23.95% (17/71) had a single HPA antibody, with 18.31% (13/71) of anti GP Ⅱb/Ⅲa, 2.82% (2/71) of anti GP Ⅰa/Ⅱa, 2.82% (2/71) of anti GP Ⅳ and 0% (0/71) of anti GP Ⅰb/Ⅸ, while 74.65% (53/71) presented multiple HPA antibodies. No statistically significant difference was found in antibody distribution among age, gender, transfusion history and disease types. 【Conclusion】 HLA-Ⅰ antibody combined with HPA antibody are the main types of platelet antibodies among children with positive platelet antibodies. Anti-GPⅡb/Ⅲa accounted for the largest proportion of HPA antibodies. Antibody distribution is not releted to age, gender, history of blood transfusion and disease types.