1.Changes in visual field and retinal nerve fiber layer thickness after Ex - press glaucoma shunt implantation
Zhen-Zhen, WU ; Wei-Lin, WU ; Guo-Wei, WU ; Shu-Nan, XU
International Eye Science 2016;16(10):1883-1885
AIM:To observe and analyze the change of visual field and retinal nerve fiber layer thickness of primary open-angle glaucoma ( POAG ) after the Ex-press glaucoma shunt implantation.
●METHODS:A total of 14 patients (24 eyes) with POAG were underwent Ex-press glaucoma shunt implantation. Visual acuity, intraocular pressure ( lOP ) , mean defect ( MD) , pattern standard deviation ( PSD ) , retinal nerve fiber layer thickness ( RNFLT ) , and corneal endothelial cell number were collected preoperatively. Visual acuity and lOP were collected in 1wk, 1 and 3mo postoperatively respectively. Also, MD, PSD, RNFLT, and corneal endothelial cell number were collected preoperatively and 3mo postoperatively respectively. Complication, the additional treatment, success rate were analyzed.
●RESULTS:There was no significant difference (P>0. 05) in visual acuity preoperative and postoperative 1wk, 1, 3mo. Visual acuity did not significantly reduce after operation. Compared with preoperative, there was significant decreased (P<0. 05) in lOP after 1wk, 1, 3mo postoperative, respectively. lOP keep stead in postoperative 3mo. The reduction of RNFLT had significant difference (P<0. 05) between preoperative and postoperative 3mo. Compared with preoperation, MD and PSD had no significant difference ( P > 0. 05 ) after postoperative 3mo. Corneal endothelial cell number decrease had significant difference (Z=-2. 585, P=0. 01) between preoperative and postoperative 3mo. Success rate: complete success: 79. 2% ( 19 eyes ); partial success:8. 3% (2 eyes);failure:12. 5% (3 eyes).
●CONCLUSION: Ex-press glaucoma shunt implantation could efficiently decrease the lOP in POAG patients. Although it results in reduction of RNFLT in short time. The visual acuity and visual field keep stable after operation. lt is a safe and effective device for treating primary open-angle glaucoma.
2.Effect of combining acupuncture and auricular point sticking on heart rate variability in patients with post-stroke depression
Lin ZHANG ; Yan ZHONG ; lin Shu QUAN ; hui Xue SHI ; guang Zhen LI ; jing Jing WANG
Journal of Acupuncture and Tuina Science 2017;15(6):392-397
Objective: To investigate the effect of combining acupuncture and auricular point sticking on heart rate variability (HRV) in patients with post-stroke depression (PSD). Methods: A total of 80 cases with PSD were randomized into a treatment group and a control group. The control group was intervened by oral administration of paroxetine hydrochloride, whereas the treatment group received acupuncture plus auricular point sticking base on the same oral administration. The Hamilton depression rating scale (HAMD) and HRV were measured before and after treatment in both groups. Results: The individual and global scores of HAMD significantly dropped after 8 weeks of treatment in both groups (all P<0.05). In the treatment group, anxiety/somatization factor, sleep disturbance, hopelessness factor, cognition factor and global score were significantly different from those in the control group (all P<0.05). The 24 h standard deviation of all normal-to-normal R-R interval (SDNN), standard deviation of 5-minute average of normal R-R intervals (SDANN), root mean square of successive differences (RMSSD), percent of differences between adjacent normal R-R intervals >50 ms (PNN50) and high frequency (HF) were increased while low frequency (LF) and LF/HF decreased significantly after 8 weeks of treatment in both groups (P<0.05). All items in the treatment group were significantly different from those in the control group (all P<0.05). Conclusion: Combining acupuncture and auricular point sticking can enhance the conventional medical treatment for HRV in patients with PSD.
3.Effects of curcumin on apoptosis and caspase-3 expression in cortex tissue in rats with hypoxic ischemic brain damage.
Guang-Mei YIN ; Lin-Sheng YU ; Shu-Zhen WU ; Guang-Hua YE
Chinese Journal of Applied Physiology 2010;26(4):504-506
Animals
;
Apoptosis
;
drug effects
;
Brain
;
drug effects
;
Caspase 3
;
metabolism
;
Curcumin
;
pharmacology
;
Hypoxia-Ischemia, Brain
;
metabolism
;
pathology
;
Male
;
Rats
;
Rats, Sprague-Dawley
4.Virtual Experiment and its Application in Physiology Teaching
Gui-Ping LIN ; Qiu-Ling XIANG ; Shu-Zhen WANG ; Ting-Huai WANG ;
Chinese Journal of Medical Education Research 2006;0(10):-
Virtual experiment is the application of virtual reality technology in experiment sciences.In the physiology teaching, virtual reality modules are made up of experiment theory module,experiment process module,virtual reality module,review mod- ule and experiment report module.We set up a virtual physiology experiment system by author ware and other software.
5.Genotype analysis of ESBLs-producing Klebsiella pneumoniae isolates
Shu-Zhen CHEN ; Rong-Lin SHI ; Fen YAO ; Ying-Mu CAI ; Yuan-Su QIAN ;
Chinese Journal of Infection and Chemotherapy 2006;0(04):-
Objective To identify the genotypes of ESBLs-producing Klebsiella pneumoniae isolates from the First Affiliated Hospital,Shantou University Medical College.Methods The MICs of 10 antibiotics were determined by agar-dilution against the clinical isolates of ESBLs-producing K.pneumoniae.PCR were performed with specific primers for blaTEM,blaSHV, blaCTX-M and blaOXA respectively.PCR products were cloned and sequenced.Results The results of PCR showed that a- mong the 83 strains of ESBLs-producing K.pneumoniae,75 were positive for blaTEM,41 positive for blaSHV,25 poitive for blaCTX-M,9 positive for hlaOXA.Three genotypes were found in 13 strains(15.7%),2 genotypes in 59 strains (71.1%) and single genotype in only 11 strains(13.2%).The genes of CTX-M-3,TEM-1 and SHV were found co-existent in 9 strains. The strains carrying 2 or 3 ESBL genes were more resistant to antibiotics than those carrying only 1 ESBL gene.Conclusions The genotypes of ESBLs-producing Klebsiella pneumoniae in this hospital are blaTEM,blaSHV,blaCTX-M and blaOXA. Most strains carry 2 or 3 ESBL genes.
7.Inhibitory effects of cyclooxygenase-2 selective inhibitor Celecoxib on human nephroblastoma.
Xiao-li HU ; Lin-sheng ZHAO ; Wei LIU ; Jian-bo SHU ; Li XU ; Zhen-fang WANG
Chinese Journal of Pathology 2012;41(5):340-341
Celecoxib
;
Cell Cycle
;
drug effects
;
Cell Line, Tumor
;
Cell Proliferation
;
drug effects
;
Cyclin-Dependent Kinase Inhibitor p16
;
genetics
;
metabolism
;
Cyclin-Dependent Kinase Inhibitor p21
;
genetics
;
metabolism
;
Cyclooxygenase 2 Inhibitors
;
administration & dosage
;
pharmacology
;
Dose-Response Relationship, Drug
;
Humans
;
Kidney Neoplasms
;
metabolism
;
pathology
;
Pyrazoles
;
administration & dosage
;
pharmacology
;
RNA, Messenger
;
metabolism
;
Sulfonamides
;
administration & dosage
;
pharmacology
;
Wilms Tumor
;
metabolism
;
pathology
8.Coupled exofixator for comminuted fracture of humeral shaft.
Hong-ru MA ; Shu-lin MA ; Tong-zhen YIN
Chinese Journal of Traumatology 2005;8(1):33-35
OBJECTIVETo report and assess the efficacy of a coupled exofixator in the treatment of comminuted fracture of the humeral shaft.
METHODSFrom June 1999 to September 2003, 24 patients with comminuted fracture of the humeral shaft were treated in our department, in whom 11 were involved in left humerus fractures and 13 in right humerus fractures. Closed reduction or open reduction with a small incision as well as a coupled exofixator was used to treat these patients.
RESULTSAll cases got anatomical reduction after 6-12 months follow-up. The time for fracture union averaged 5.8 months with a good functional recovery of the shoulder-elbow joints.
CONCLUSIONSThe coupled exofixator is favorable to the treatment of comminuted humeral shaft fractures. It can shorten union time and avoid nonunion occurrence.
Adolescent ; Adult ; External Fixators ; Female ; Fracture Fixation ; methods ; Fractures, Comminuted ; surgery ; Humans ; Humeral Fractures ; surgery ; Male ; Middle Aged ; Treatment Outcome
9.Correlation between level of TSH receptor antibody and activity of Graves ophthalmopathy after treatment with glucocorticoid
Hai-Bing JU ; Guang-Lin WANG ; Deng-Ming HU ; Zi-Zhen SHU ; Zi-Yin ZHU ; Fei-Fei SHEN ;
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
Fifty-six patients with Graves' ophthalmopathy(GO)were treated with antithyroid drug and oral prednisone for three months,TSH receptor antibody(TRAb)level was reduced,GO activity and severity of some patients were ameliorated but still positively associated with TRAb.It suggests that TRAb not only triggers off GO but also plays a possible role in the maintenance of the autoimmune process in GO.
10.Effect of subtotal proctocolectomy with modified Duhamel anastomosis on anal function in patients with slow transit constipation complicated with adult megacolon.
Yong Bang WANG ; Zhong Cheng HUANG ; Zhi Gang XIAO ; Shu Lin HUANG ; Wei YAN ; Wei Zhen LUO
Chinese Journal of Gastrointestinal Surgery 2021;24(12):1096-1099