OBJECTIVE: To study the chemical constituents of Ixeris chinensis Nakai. METHODS: The constituents were isolated by silica gel column chromatography, HPLC and recrystallization, and their structures were elucidated on the basis of spectral analysis. RESULTS: Fifteen compounds were isolated and identified as Chinensioide F(1), Chinensioide C(2), daucosterol(3), 6'-phydroxyphenylacetyl-Ixerin D(4), methyl-4-hydroxyphenylacetate(5), p-hydroxyphenylethanol(6), 3,5-dimethoxy-4-hedroxyphenylpropynol(7), 10α-hydroxy-guaia-12,6-lactone-3-keton(8), sitosterol(9), Chinensioide E(10), Chinensioide D(11), Ixerochinoside(12), 3β,10α-dihydroxy-guaia-4(15), 11(13)-diene-12,6-lactone(13), 10α-hydroxy-11βH-guaia-4(15)-ene-12,6-lacton(14) and luteolin-7-O-β-D-glucoside(15). CONCLUSION: Compound 1 is new (chinensiode F). Compound 4~7 and 12~14 were isolated from I. chinensis Nakai for the first time.

Objective To study the chemical constituents from the bark of Juglans mandshurica. Methods The compounds were isolated and purified by column chromatography on silica gel,HPLC,and recrystallization.Their structures were elucidated by the physicochemical and spectroscopic evidences. Results Fifteen compounds were identified as:4,8-dihydroxynaphthalenyl-O-?D-(6′-acetoxyl)gluco- pyranoside(Ⅰ),dihydrokaempferol(Ⅱ),juglone(Ⅲ),daucosterol(Ⅳ),kaempferol(Ⅴ),4,8-dihy- droxynaphthalenyl-1-O-?-D-[6′-O-(3″,5″-dimethoxy-4″-hydroxybenzoyl)] glucopyranoside(Ⅵ), kaempferol-3-O-?-L-rhamnoside(Ⅶ),3,3′-dimethoxylellagic acid(Ⅷ),naringenin(Ⅸ),quercetin (Ⅹ),reginolone(Ⅺ),quercetin-3-O-?-L-rhamnoside(Ⅻ),naringenin-7-O-?-D-glucoside(ⅩⅢ),4,8- dihydroxynaphthalenyl-1-O-?-glucoside(ⅩⅣ),4,5,8-trihydroxy-?-tetralone-5-O-?-D-[6′-O-(4″-hy- droxy-3″,5″-dimethoxy-benzoyl)] glucoside(ⅩⅤ).Conclusion CompoundⅠ(juglamanol)is a new compound.CompoundsⅡ,Ⅶ—Ⅸ,Ⅻ,andⅩⅢare isolated from plants of Carya Nutt.for the first time.

Objective:To observe the effect of rapid point pressure on clinical effect and pulmonary function of patients with chronic persistent bronchial asthma.
Methods:A total of 60 confirmed chronic persistent bronchial asthma cases were randomly allocated into two groups, 30 in each group. Cases in the treatment group were treated with rapid point pressure, 1 h for the initial treatment, and 40 min for the ensuing treatments. The treatment was done once a day for 40 d. Cases in the control group were treated with Compound Methoxyphenamine Hydrochloride Capsules, 2 capsules for each dose, 3 times a day. The treatment lasted for 7 consecutive days. A 1-year follow-up was made for both groups.
Results:After treatment, the scores of each symptom and total symptom scores for the traditional Chinese medicine (TCM) symptoms in the treatment group were significantly higher than those in the control group (P<0.05);the total effective rates in the treatment group were higher than those in the control group in each time frame; and there was a between-group statistical significance in total effective rate after 7 d of treatment (P<0.01). After 40-day treatments, there were statistical significances in the forced expiratory volume in 1 s percentage of predicted value (FEV 1%) and inspiratory capacity (IC%) in the treatment group (P<0.05); however, there were no statistical significances (P>0.05) in forced expiratory volume in 1 second to forced vital capacity ratio (FEV1/FVC), peak expiratory flow rate (PEF%) and maximum midexpiratory flow rate (MMEF%); and there were no statistical significances in pulmonary function parameters in the control group. In addition, as for pulmonary function parameters, there were no intra-group statistical significances in differences before and after treatment (P>0.05).
Conclusion:Rapid point pressure can alleviate patients’ TCM symptoms and improve their FEV%and IC%.

Anti-Bacterial Agents ; therapeutic use ; Chronic Disease ; Diagnosis, Differential ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Male ; Medicine, Chinese Traditional ; Phytotherapy ; Prostatitis ; diagnosis ; drug therapy

Objective To discuss the clinical methods and curative effect of minimally invasive percutaneous plate osteosynthesis ( MIPPO) technique applied in the treatment of humeral shaft fractures. Methods A retrospective analysis was applied on 14 patients with humeral fracture underwent the MIPPO operation in our department from April 2012 to March 2013. There were 8 males and 6 females, with their ages ranging from 28 to 64 years. Results Fourteen cases were followed up for 2 months to 12 months (an average of 6 months) . Their incisions got primary healing. The fracture segments got satisfactory reduction with good apposition and alignment radiologically, and the radial never function recovered well. UCLA score concluded as excellent in 13 cases and good in 1 case. Conclusion MIPPO is a safe and effective treatment for the humeral fracture with the benefits of less invasion, fewer complications and higher union rate.

AIM:To evaluate the changes of lung morphologic features and oxidative stress in experimental diabetic rats. METHODS: The pulmonary structure of alloxan-induced diabetic rats were quantitatively studied with stereological methods. Changes of ultrastructure, activities of superoxide dismutase (SOD) and contents of malondialdehyde(MDA) of diabetic lung and serum were observed. RESULTS: The volume proportion of alveolar air and mean linear intercept of diabetic rats decreased remarkably in comparison with controls while the volume proportion of alveolar wall, the surface density of alveolar, the numerical density of alveolic area, the numerical density of alveolar and specific surface of alveolar increased significantly. The major change of the type II pneumocyte of diabetic rats was dilation of the rough endoplasmic reticulum (RER). The other findings in diabetic rats had included the presence of thickened alveolar epithelial, pulmonary capillary basal laminae and blood- air barrier, the volume density, the surface density, the mean profile area and the mean perimeter of RER in type Ⅱ pneumocyte of diabetic rats increased remarkably. And the specific surface of RER was significantly lower as compared with controls. SOD activity decreased and MDA content increased significantly in serum of diabetic rats as compared with the control group. SOD activity in the diabetic lung was not different from that of the control lung. However, the content of MDA obviously increased in diabetic lung. CONCLUSION: The morphologic features and oxidative stress in early diabetic rats are abnormal thus the lung should be considered as one of the “target organ”in diabetes mellitus.

AIM To study the therapeutic effects of Deketoprofen trometamol (D KPT) on adjuvant arthritis (AA) and its side effects on gastroduodena. METHEDS The change of primary and secondary inflammatory and the injury effect of gastroduodena treated with D KPT were observed. The effect of D KPT on prostaglandin E 2 (PGE 2) produced by peritoneal macrophage (PM) on AA rats in vitro was also observed. RESULTS D KPT (2 5, 5, 10 mg?kg -1 ) significantly inhibited primary inflammatory, secondary inflammatory and multiple arthritis of AA rats. D KPT(10 -8 ,10 -7 ,10 -6 ,10 -5 ,10 -4 mol?L -1 )inhibited the elevated PGE 2 released from PM of AA rats in vitro . D KPT (10 mg?kg -1 ) significantly injured gastroduodena on AA rats, but the degree of injuries was less than that of ketoprofen (KP) (10 mg?kg -1 ). CONCLUSION D KPT has therapeutic effects on AA rats, and its injury effect on gastroduodena is less than that of KP.

Objective: To study the chemical constituents of Artemisia argyi. Methods: The chemical constituents were isolated by silica gel column chromatography and HPLC, and its structure were identified by their spectral data and physicochemical properties analysis. Results: Thirty-four compounds were isolated from A. argyi with the structures identified as 5-hydroxy-6,7,3’,4’- tetramethoxyflavone (1), eupatorin (2), p-hydroxy-acetophenone (3), raspberry ketone (4), zingiberone (5), 7-hydroxycoumarin (6), p-hydroxybenzoic acid (7), desacetoxymatricarin (8), 3α-hydroxy-1(10),4,11(13)-triene-12,6α-olide (9), jaceosidin (10), 7-hydrxyterpineol (11), cis-2,8-dihydroxy-p-mentha-1(7)-en (12), trans-2,8-dihydroxy-p-mentha-1(7)-en (13), artemisetin (14), scopoletin (15), arteminolide C (16), desacetylmatricarin (17), artecalin (18), 11,13-dehydrodesacetylmatricarin (19), 1,9-azelaic acid (20), 3-methoxy-tanapartholide (21), phaseic acid (22), seco-guaiaretic acid (23), 5,3’,4’-trihydroxy-6,7-dimethoxy-flavone (24), 1,7-pimelic acid (25), 10-epi-ajafinin (26), 3-epi-iso-seco-tanapartholide (27), austroyunnane C (28), artanomaloide (29), ligustolide A (30), seco-tanapartholide B (31), 3-dehydroxy-iso-seco-tanapartholide (32), 3α-hydroxyreynosin (33), dihydrophaseic acid (34). Conclusion: Compounds 4, 22, 25, 30, 33, 34 are separated from the Artemisia for the first time. Compounds 5, 7, 8, 11-13, 21, 23, 24, 26-28 are isolated from A. argyi for the first time.

Objective To study the chemical constituents from the leaf of Syringa oblata. Methods The compounds was isolated by silica gel column chromatography and HPLC, and their structure were identified by spectral data analysis. Results A total of 35 compounds were isolated and identified as oleanolic acid (1), ursolic acid (2), betulinic acid (3), 1,3-benzodioxole-5-propanol (4), p-hydroxyl benzene propyl alcohol (5), p-hydroxyl benzene ethel alcohol (6), syringopicrogenin D (7), syringopicrogenin E (8), syringopicrogenin F (9), syringopicrogenin A (10), syringopicrogenin C (11), 3,4-dihydroxyl benzene ethel alcohol (12), syringobittergenin B (13), syringo-picrogenin B (14), grasshopper ketone (15), (7R,8S)-4,9,9’-trihydroxyl-3,3’-dimethoxyl-7,8- dihydrobenzofuran-1’-propylneolignan (16), lariciresinol (17), syringin (18), 3(Z)-enol glucoside (19), quercetin-3-O-β-D- glucopyranoside (20), (8E)-ligstroside (21), epipinoresinol-4-O-β-D-glucopyranoside (22), (8E)-ligstroside B (23), (8E)-ligstroside A (24), salidroside (25), 7-dehydrologanin (26), fliederoside B (27), syringopicroside B (28), oleoside dimethyl ester (29), lilacoside (30), syrigopicroside (31), oleuropein (32), (+)-lariciresinol-4-O-β-D-glucopyranoside (33), verbascoside (34), and (+)- epipinoresinol-4’-O-β-D-glucopyranoside (35). Conclusion Compounds 4, 5, 14-16, 19, 23, 24, 26, and 27 are isolated from S. oblata for the first time.

Objective: To study the chemical constituents in the whole herbs of Xanthium mongolicum. Methods: The chemical constituents were isolated and purified by chromatography on silica gel column and HPLC, and their structures were elucidated by spectral analysis. Results: Seventeen compounds were isolated and identified as lasidiol p-methoxybenzoat (1), β-selinene (2), xanthatin (3), xanthinosin (4), luteone (5), daucosterol (6), 4β,5β-epoxy xanthatin-1α,4α-endoperoxide (7), (6S,9R)-vomifoliol (8), dehydrovomifoliol (9), 3(Z)-hexenyl-β-D-glycoside (10), 4-oxo-bedfordia acid (11), 11α,13-dihydro-8-epi-xanfbut (12), scopolin (13), pinoresinol (14), β-sitosterol (15), quercetin (16), and methyl p-hydroxybenzonate (17). Conclusion: The compounds 2, 8, 9, 10, and 17 are isolated from the plants of Xanthium L. for the first time and the compounds 1, 5, 7, 11 and 13 are isolated from the whole herbs of X. mongolicum for the first time.