Objective Research to the quality of life and its influencing factors of Alzheimer's caregivers.Methods Use of general questionnaire and health questionnaire(SF-36)to measure and evaluate 50 cases of Alzheimer's caregivers'quality of life,using spearman correlation analysis and multiple regression analysis of influencing factors.Results SF-36 score of the families of Alzheimer's patients and eight dimension scores were lower than the normal,the difference was statistically significant(P＜0.05);In which a sense of general health(44.39±17.31)points,mental state(42.99±22.39)points.The factors of influencing caregiver's life quality are their gender, age, education level, economic status,time,cost,payment method,the severity of patients with dementia,mental and behavioral symptoms and relationship.Conclusions The quality life of Alzheimer's caregivers was poor,the factors was extensive.Therefore,it is given our attention to concern with Alzheimer's patients,as well as their caregivers,and connected the medical institutions with community services and home care,in order to reduce the burden of caregivers and improve their quality of life.

Cardiac Catheterization ; Heart Septal Defects, Ventricular ; therapy ; Humans ; Prosthesis Implantation ; instrumentation ; Septal Occluder Device

Objective To observe the effect of ear acupuncture point treatment for insomnia patients of kidney deficiency. Methods A total of 91 cases of insomnia patients with kidney deficiency were randomly divided into two groups: 46 cases of treatment group and 45 cases of control group. Patients in treatment group underwent ear acupuncture point treatment for 1 months, two ears in turn, three days changed. While patients in control group only used warm water treatment. Results The effective rate of treatment group was significantly higher than that in control group ( P < 0. 01). Except for sleeping efficiency and daytime function factor of PSQI factor score, the other score in treatment group was significantly lower than that in control group (P < 0. 05). The SAS score of treatment group had significant difference, (P <0. 01). There was no significant difference in terms of the rate of adverse effect between groups (P >0. 05); The positive symptom of anxiety and depression in treatment group was significantly lower than that in control group. Conclusions The effect of ear acupuncture point treatment can improve sleep quality and psychological health of patients of kidney deficiency, its uncomfortable rates has no significant difference compared with that in hot water footbath therapy.

OBJECTIVETo determine the prevalence and risk factors of retinal diseases of preterm infants and full term for newborns small gestational age born (SGA) by using wide-angle digital retinal imaging system (RetCam3).

METHODSClinical data of 779 preterm and SGA infants whose eyes were detected by RetCam3 between January and December 2013 before discharge were studied retrospectively.

RESULTSAmong the 779 infants, there were 69 cases of retinal hemorrhage (8.9%), 10 cases (1.3%) of retinopathy of prematurity (ROP), 9 cases of retinal exudative changes, 4 cases of retinal myelinated nerve fibers, 2 cases of congenita cataract, 3 cases of retinal chromatosis, 2 cases of retinal crystalline changes and 1 case of retinoblastoma. Logistic regression analysis indicated that low birth weight and gestational age and the history of oxygen inhalation were risk factors for the development of ROP and that vaginal delivery and mechanical ventilation increased the risk of retinal hemorrhage.

CONCLUSIONSNeonatal fundus diseases may be so various and harmful that early fundus screening should be carried out on high-risk infants, such as preterm and SAG infants. Preventive measures should be taken against the risk factors for fundus diseases.

Birth Weight ; Female ; Fundus Oculi ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Neonatal Screening ; Retinal Hemorrhage ; diagnosis ; etiology ; Retinopathy of Prematurity ; diagnosis ; etiology ; Risk Factors

OBJECTIVETo evaluate their long-term outcome and the efficacy and economic significance of antiviral drugs by investigating the long-term health-related quality of life (HQL) in chronic hepatitis B (CHB) patients.

METHODSThe HQL of 101 CHB patients with biopsy-proven 6 to 18 years ago and 105 persons of general population as control was studied with revised SF-36 questionnaire.

RESULTSThe HQL in CHB patients was lower than that in general population in physical functioning, role physical, general health, mental health, and specific symptoms (mu > or = 2.10, P<0.05).

CONCLUSIONSThe long-term HQL in chronic hepatitis B patients is poor.

Adolescent ; Adult ; Antiviral Agents ; therapeutic use ; Cost of Illness ; Female ; Follow-Up Studies ; Hepatitis B, Chronic ; drug therapy ; economics ; Humans ; Male ; Middle Aged ; Quality of Life ; Surveys and Questionnaires

Objective To observe the clinical effect of adjustable moxibustion box on kidney-deficiency related lumbago. Methods 97 kidney-deficiency related lumbago patients were randomly divided into treatment group (48 patients) and control group (49 patients). Treatment group was treated by adjustable moxibustion box, while the control group accepted the traditional moxibustion box. Duration of the treatment was two weeks.Results The overall efficacy of the treatment group 85.41% was significantly higher than that of the control group 71.43% ( x2 =4. 841 ,P =0. 027 8 ). The overall incidence of local skin burning sensation and side effect of the treatment group was lower than that of the control group ( P ＜ 0. 01 or P ＜ 0. 05 ). Conclusions Treatment with adjustable moxibustion box improves the efficacy and reduces side effects, which is an effective therapy to the kidney-deficiency related lumbago.

We present here the case of a 40-year-old woman with a greater than 10 year prior history of bilateral breast silicone injection and saline bag implantation. Bilateral palpable breast nodules were observed, but the ultrasound scan was suboptimal and the magnetic resonance imaging showed no gadolinium-enhanced tumor. The 18F-FDG PET/CT scan showed a hypermetabolic nodule in the left breast with a 30% increase of 18F-FDG uptake on the delayed imaging, and this mimicked breast cancer. She underwent a left partial mastectomy and the pathology demonstrated a siliconoma.
Adult ; Breast Implants/adverse effects ; Breast Neoplasms/diagnosis ; Diagnosis, Differential ; *False Positive Reactions ; Female ; Fluorodeoxyglucose F18/diagnostic use ; Granuloma, Foreign-Body/*diagnosis ; Humans ; Injections ; *Positron-Emission Tomography ; Radiopharmaceuticals/diagnostic use ; Silicones/administration & dosage/*adverse effects ; *Tomography, X-Ray Computed

Objective To investigate the effect of supine regulating on maternal fetal occiput posterior position during the delivery after epidural analgesia. Methods Totally600 cases of parturient with intravaginal posterior occipital position with 3cm voluntary labor analgesia were selected,who were born in Dalian maternity hospital from October 2015 to October 2016.The(Visual Analogue Scale/Score) VAS pain score at 15min after epidural labor analgesia was as effective as less than 3 points.They were randomly divided into the control group and the observation group by random number table method,with 300 cases in each group.The control group monitored parturient respiration, pulse, blood pressure, heart rate and fetal heart rate according to routine treatment.The control group monitored parturient respiration, pulse, blood pressure, heart rate and fetal heart rate according to routine treatment.In the observation group,except for routine treatment according to the labor process,after the opening of 5cm,the pregnant women were instructed to take the lateral prone position,so that the maternal side and the fetal side of the spinal column should be the same side. To observe the difference between the two groups in the rate of spontaneous vaginal delivery, delivery rate, cesarean section rate, fetal cardioversion rate, time of birth process and neonatal Apgar score. Results Totally 283 cases delivery through vagina and 17 cases of cesarean section in observation group,while 257 cases of vaginal delivery and 43 cases of cesarean section in the control group.The successful rate of fetal position transfer in the observation group was 74.6%(211/283) which was significantly higher than 45.9% (118/257) of the control group (Χ2=62.782, P<0.01), natural labor rate was also 87.3% (262/300) which increased significantly according to 64.7% (194/300) (Χ2=42.251, P<0.01),the rate of midwifery (7.0%, 21/300) and cesarean section (5.7%, 17/300) were significantly lower than 21.0% (63/300)and 14.3% (43/300) of the control group (Χ2=24.419, 12.519,P<0.01),the second stage of labor was(1.60±0.56)h which was significantly shortened than(2.19±0.53)h also(t=-12.589,P<0.01).In the observation group, the ratio of the posterior occipital position to the occipital transverse position after the opening of 8-10 cm and the complete dilation of the cervical were 7.4%(21/283)and 13.1%(37/283),which were also significantly increased than 3.4%(9/264),6.8%(18/264) of the control group (Χ2=4.240, 5.911, P<0.05). Conclusions Supine adjustment after the cervix dilatation larger than 5cm is more conducive to fetal rotation and to avoid the adverse complications, reduce the rate of vaginal delivery and cesarean section rate,improve the rate of natural childbirth,shorten delivery time,improve the quality of delivery.

Objective To observe the effect of the Jianpiyishenfang decoction combined with acupuncture and moxibustion and Rocalirol for curing maintenance hemodialysis patients with renal osteodystrophy disease. Methods 30 cases of maintenance hemodialysis(MD)patients were randomly divided into two groups. "treatment group of 15 cages "and "control group of 15 cases".The treatment group took Jianpiyishenfang twice a day,and accepted acupuncture and moxibustion for three times one week combined with Rocalirol,0.25 μg,qd.During the treatment,the drug including EPO,the dialysis parameters,such as blood flowing volume per minute and dialyzer type and hemedialysis machine were all the same.The control group took Rocalirol,0.25 μg,qd,only.3 months'observation was conducted.For the two groups,measuring the changes of Ca2+,P3+,PTH,B-MG,Scr,UA,BUN,HGB and so on was performed.Results The treatment group,which accepted the treatment of Jianpiyishenfang decoction combined with acupuncture and moxibustion and Rocalirol,exhibited a relief of the degree of bone pain and an alleviation of the symptoms of cramp, with the difference being significant(P<0.05).But on the aspects of changes of Ca2+.P3+,PTH,and β-MG data, it showed no dominant difference(P<0.05).Conclusions,The combined treatment of the Jianpiyishenfang decoction with acupuncture and moxibustion and Rocalirol can obviously relieve the degree of bone pain.regulate the balance of Ca2+,P3+ metabolism,and reduce the level of serum PTH and β-MG,SO as to treat the renal osteodystrophy disease.

Objective To investigate the expression changes and effects of hypoxia inducible factor1α (HIF-1α) on non-lethal high temperature induced thermotolerance and its role on thermotolerance protection.Methods H9c2 cardiomyocytes were cultured and pretreated with the HIF-1α inhibitor YC-1,the cells were then subjected to normal temperature (37 ℃),thermotolerance induction (40 ℃,3 h),or hyperthermia (43 ℃,2 h).The cells were divided into 8 groups (n =3 each):normal temperature control group ; thermotolerance group ; thermotolerance/hyperthermia group ; hyperthermia group ; DMSO + normal temperature group; YC-1 + thermotolerance group; YC-1 + thermotolerance/hyperthermia group; YC-1 +hyperthermia group.Cell apoptotic rate was assessed by flow cytometry.Western blot was used to detect the expression of HIF-1 α and caspase-3.Results Flow cytometry results showed that apoptosis rate was similar between control group and thermotolerance group,between DMSO + normal temperature group and YC-1 + thermotolerance group,between YC-1 + thermotolerance/hyperthermia group and YC-1 + hyperthermia group,but was significantly higher in hyperthermia group [(17.35 ± 1.07)％] than in control group [(7.52 ± 1.55)％,P ＜ 0.01] which was partly reduced in thermotolerance/hyperthermia group [(12.58 ± 1.97)％,P ＜ 0.01 vs.thermotolerance group].Cell apoptosis rate of YC-1 + thermotolerance/hyperthermia group (23.75 ± 1.92) ％ was significantly higher than that of thermotolerance/hyperthermia group [(12.58 ± 1.97) ％,P ＜ 0.01],and in YC-1 + hyperthermia group [(24.89 ± 1.83) ％] than in hyperthermia group [(17.35 ± 1.07) ％,P ＜ 0.01].HIF-1α expression was obviously upregulated in thermotolerance cells compared with control cells,in thermotolerance/hyperthermia cells than in hyperthermia cells,in YC-1 + thermotolerance group,YC-1 + thermotolerance/hyperthermia group and YC-1 + hyperthermia group than in DMSO group (all P ＜ 0.05).Caspase-3 expression was similar between control group and thermotolerance group,but was significantly lower in thermotolerance/hyperthermia group than in hyperthermia group (P ＜ 0.05),significantly higher in YC-1 + thermotolerance group,YC-1 + thermotolerance/hyperthermia group and YC-1 + hyperthermia group than in DMSO group (all P ＜ 0.05) and significantly higher in YC-1 + thermotolerance/hyperthermia group than in thermotolerance/hyperthermia group (P ＜ 0.01) and in YC-1 + hyperthermia group than in hyperthermia group (P ＜ 0.01).Conclusion Non-lethal high temperature induced thermotolerance can reduce heat stress-induced cardiomyocytes apoptosis rate via upregulating the expression of HIF-1 α and inhibiting caspase-3 signalling pathways.