Fatal Outcome ; Humans ; Infant ; Intracranial Hemorrhages ; etiology ; Male ; Siblings ; Vitamin K Deficiency ; complications

Chinese medicine industry is the new strategic industry with comparative advantage in China. To achieve modernization of Chinese medicine, improving the competitiveness of Chinese medicine enterprise is an inevitable choice. Based on the method of factor analysis and cluster analysis, this article measured and analyzed the competi-tiveness of 42 Chinese medicine listed companies by using the data of year 2012. The result showed that the com-petitiveness of Chinese medicine enterprises was mainly affected by three factors, which were scale of operation, profitability efficiency and growth. The scale of Chinese medicine is small and the large gap of competitiveness ex-its. To enhance the competiveness of Chinese medicine enterprises, this paper put forward corresponding develop-ment recommendations combined with the advantages and disadvantages of Chinese medicine enterprises.

OBJECTIVE:To explore the approach for the improvement and extension of the function of pharmaceutical services in modern hospitals.METHODS:The development of our pharmacy department in recent years was analyzed,aimed at the actual demands of hospitals and patients and in view of the advantages of our department,the new entry point for the pharmaceutical services was explored.RESULTS & CONCLUSIONS:By improving the workflow of prescription dispensing,the time for patients to have their prescriptions filled can be greatly shortened and is left for pharmacists to collect drug-related information based on the demands of both patients and clinic and provide professional guidance so as to increase the weight of patients in the treatment course,which is in the interest of medication safety,patients and hospital.

AIM: To study the expression level of gene SNC66 in gastric cancer tissues, and investigate the relationship between the expression of SNC66 and the pathogenesis of gastric cancer.METHODS: Paired normal and cancerous paraffin-embeded tissues from 20 gastric cancer patients were tested by in situ hybridization (ISH) and in situ reverse transcription and polymerase chain reaction (ISRT-PCR)using ?-actin as a control.RESULTS: ISH and ISRT-PCR both showed that SNC66 were all strong positive expressed in 20 normal gastric mucosa.But in 20 gastric cancer tissues,the ISH showed that 8 were negative,8 were weak positive and 4 were strong positive. The ISRT-PCR showed that 6 were negative,9 were weak positive and 5 were strong positive when the PCR cycled 10 times;4 were negative and 16 were strong positive when the PCR cycled 25 times. CONCLUSION: There was significant expression reduction or defect of SNC66 in gastric cancer tissues.SNC66 should be further investigated as a gastric cancer negative relative gene.

Objective: To investigate the clinical effect of ginger-partitioned moxibustion at Zigong (EX-CA 1) for primary dysmenorrhea. Methods: A total of 112 patients with primary dysmenorrhea were randomized into an observation group and a control group according to their visiting sequence, 56 cases in each group. Patients in the observation group received ginger-partitioned moxibustion at Zigong (EX-CA 1), while patients in the control group received oral intake of analgesic. For both groups, treatment started 1 week before menstruation and lasted for 3 menstrual cycles, continued by a 3-month follow-up visit, then the clinical efficacy was evaluated. Results: By the end of treatment, symptom score in the observation group was lower than that in the control group, showing a statistical significance (P<0.05). After 3 months of treatment, the value of prostaglandin F2a (PGF2α), systolic-to-diastolic peak velocity ratio (S/D), resistance index (RI) and pulsatility index (PI) in the observation group were significantly higher than those in the control group, showing statistical significances (all P<0.01).The recovery rate in the observation group was higher than that in the control group, showing a statistical significance (P<0.05). Conclusion: Ginger-partitioned moxibustion at Zigong (EX-CA 1) for primary dysmenorrhea is a combination of the merits of warming function of moxibustion, dissipating function of ginger and stimulation of acupoint, and is better than oral intake of analgesic.

Objective:To study the effects of enamel matrix proteins (EMPs) on the biological characters of osteoblasts.Methods:MC3T3-E1 osteoblasts were cultured in vitro and exposed to EMPs at 300,400 and 500 ?g/ml.Enzyme kinetic method was used to assay alkaline phosphatase (ALP) synthesis and 3H-proline labelling combining collagenase digestion method was used to assay type I collagen synthesis.Results:The results manifested that ALP level in EMPs treated groups was higher than that in control group (P

Objective To explore the key elements in prescription and summarize the law of prescription-herb treatment, to find core herbs/herb group which play a key role in pharmacological effects, then provide new methods and modern techniques for theory of prescription development and TCM clinical research. Methods The text data sources of stroke disease were retrieved from databases of traditonal Chinese prescription. After pre-processing and information extraction, a prescription-herb matrix was constructed, and then biclustering method was used to simultaneous clustering two dimensions of data. Results Totally 648 effective records were gained after preprocessing, and 6913 herbs were extracted, then a 100×648 prescription-herb matrix was generated. Finally 4-way clustering results were output, along with 8 high descriptive prescriptions, then characteristics of prescription laws of diagnosis and treatment according different syndrome and various types of herbs commonly used were summarized. Conclusion This method can be well applied for prescription-herb knowledge discovery in TCM prescription databases. The prescription-herb information can be effectively extracted, and laws of prescription-herb and syndrome-treament can be mined.

Biliary Tract Diseases ; etiology ; prevention & control ; therapy ; Cholestasis ; etiology ; prevention & control ; therapy ; Humans ; Liver Transplantation ; adverse effects

Objective:To compare the marginal fit changes between after-and before-veneering of the copings using three kinds of materials:gold alloy,cp titanium and Ni-Cr alloy,so as to determine whether the fit changes was influenced with the veneer and their clinical significance.Methods:24 maxillary incisor acrylic resin PFM abutments fabricated by machine with the consolidated standard were divided into three groups,each abutment was waxed-up,invested,and casted with three kinds of materials:gold alloy,cp titanium and Ni-Cr alloy.For all groups,the copings were repositioned on their respective abutments,the marginal fit values of four points of each coping were measured.Furthermore,after three groups of copings were veneered with recommended porcelain,marginal fit values of same point of each abutment were remeasured.SAS software was used to carry out statistical analysis.Results:One way analysis of variance of marginal fit values revealed significant differences between before and after veneering in three groups,and the marginal fit value enhanced after veneered.Among three groups,cp titanium group had a significant difference when compared with other two groups(P

A study was made of the effects of carboxymethyl modified hemi-cellulose ( CMMH ) on the immune reaction in mice. When it was administered with 1.5% 300mg/kg ip daily for 5 d, CMMH remarkably enhanced the phagocytic activity of peritoneal exudate macro-phages(P