Humans ; Periodontal Diseases ; complications ; microbiology ; Periodontium ; microbiology ; Systemic Inflammatory Response Syndrome ; microbiology

Colorectal Neoplasms ; diagnosis ; prevention & control ; Humans ; Translational Medical Research

Equipment Design ; Humans ; Pacemaker, Artificial

Objective To explore the prognostic factors of osteosarcoma.Methods Clinical data of 32 cases with osteosarcoma were retrospectively reviewed.Sex,age,course of disease,serum level of alkaline phosphatase (AKP),tumor size,tumor site,Enneking surgical stage,surgical method and distant metastasis were statistically analyzed.Results All the patients were followed up,and 12 patients died with a median survival of 6-52 (40.28 ± 5.58) months.Overall survival rate of 3 years was 62.5％ (20/32).Univariate analysis revealed that the prognosts of osteosarcoma was significantly related to tumor site,Enneking surgical stage,surgical method and distant metastasis.Multivariate analysis suggested that Enneking surgical stage,surgical method and distant metastasis were independent prognostic factors.Conclusions Enneking surgical stage,surgical method and distant metastasis are independent prognostic factors.Early diagnosis and the radical resection of tumor can improve the prognosis.

ObjectiveTo explore salivary concentration of carcinoembryonic antigen (CEA),interleukin (IL)-6,IL-8 in oral squamous cell carcinoma and its' clinical significance.MethodsForty-two cases with oral squamous cell carcinoma were selected as experience group and 50 healthy persons as control group.ELISA method was performed to detect CEA,IL-6,IL-8 level of salivary and serum in two groups.ResultsThe salivary concentration of CEA,IL-6 and IL-8 was (62.37 ± 20.80)μ g/L,(79.12 ± 30.26)ng/L,( 834.61 ± 231.85 ) ng/L respectively in experience group,(25.72 ± 12.65 ) μ g/L,(0.58 ± 0.25 ) ng/L,(209.71 ± 67.92) ng/L in control group.There was significant difference between two groups(P＜ 0.01 ).The serum concentration of CEA,IL-6 and IL-8 was(61.15 ± 23.69)μ g/L,(58.17 ± 12.83) ng/L,(852.31 ±172.97) ng/L respectively in experience group,and IL-6 level of serum were much lower than that of salivary (P ＜ 0.05).ConclusionsCEA,IL-6 and IL-8 can be biomarkers of oral squamous cell carcinoma.Salivary detection is an ideal auxiliary diagnosis method for its simplicity and sensitivity.

The organic cation transport systems were initially recognized in studies of renal elimination.A variety of endogenous and exogenous compounds that are harmful to the body are eliminated from the kidney via glomerular filtration and/or active tubular secretion.Among those compounds are polar organic cations that require a transporter-mediated process to cross cellular membrane and be eventually excreted into the urine.The organic cation transport systems in the kidney have been recognized for several decades.Following the insight gained from the kidney,organic cation transporters (OCTs) have also been characterized in other tissues.In particular,the OCTs in the liver and in the intestine have been proposed as important determinants of drug absorption and disposition.Over the past several decades,the mechanisms of organic cation transport have been extensively characterized using in vivo models,ex vivo organ perfusions,in vitro tissue preparations and cell lines.In particular,the molecular cloning and characterization of OCTs have remarkably increased our knowledge of this important subfamily of solute carriers.In this article,we first review the molecular cloning and characterization of OCTs.We will then describe their transport mechanisms,tissue distribution and localization,and their specificity of interaction with organic cations.Regulatory mechanisms and genetic animal models will be reviewed as they provide the most important insight on this class of transporters in recent years.Finally,we will summarize genetic variation in human OCT genes and raise clinical perspectives on these important transporters.

Objective:To screen auramine O in Guci tablets. Methods:Auramine O was detected by HPLC method on a Diamon-sil-C18(250mm×4.6mm,5μm)columnwiththemobilephaseofacetonitrile-0.025mol·L-1monopotassiumphosphatebuffersolu-tion(containing 0. 2% triethylamine,adjusting pH to 3. 0 with phosphoric acid)(36∶65)at the flow rate of 0. 8 ml·min-1. The detec-tion wavelength was 432 nm and the column temperature was 35℃. Results:The LOD of auramine O was 0. 05ng. Among 45 batches of tested samples, auramine O was found in seven ones. Conclusion:The method is simple, rapid and accurate, which can guarantee the drug safety of Guci tablets.

Intracranial pressure monitoring is a mainstay in the management of children with severe traumatic brain injury.The research issues on the intracranial pressure monitoring have become important for neurocritical care.This paper has reviewed the significance of intracranial pressure monitoring in children with severe traumatic brain injury.

BACKGROUND:There is no unified conclusion on the efficacy of immediate implantation and restoration. Some studies have shown that the success rate and aesthetic effect of immediate implantation are better than those of delayed implantation. However, in other studies, the immediate implantation has no difference from the delayed implantation, and it also has safety hazards. OBJECTIVE:To observe the clinical efficacy and safety of BLB implant for immediate implantation and delayed implantation. METHODS:Eighty patients undergoing denture implantation and restoration, 35 males and 45 females, aged 20-52 years were equaly divided into research group treated with immediate implantation of BLB implant and control group treated with delayed implantation. Crown restoration was completed at 3 months after implantation. Then, the patients were folowed up for 6 months to observe the implant stability, implantation efficacy and adverse effects. RESULTS AND CONCLUSION:There was no intra-group or intergroup difference in the implant stability quotients of two groups at 1, 3, 6 months after restoration (P> 0.05). The total effective rate was 95% in the research group and 90% in the control group, and there was no significant difference between the two groups (P > 0.05). In the research group, there was one case of gingivitis and one case of lower lip numbness; in the control group, there were two cases of wound infection and one case of lower lip numbness, but there was no difference in the incidence of complications between the two groups (P > 0.05). These findings indicate that BLB implant has good efficacy and safety both in immediate implantation and delayed implantation.

Objective To explore the value of hepcidin measurement in differential diagnosis of iron deficiency anemia(IDA) and anemia of chronic diseases(ACD) .Methods Serum hepcidin was measured by using ELISA .Serum iron(SI) and total iron binding capacity(TIBC) were determined by using Ferro zine colorimetric method .Results Hepcidin expression increased in ACD group (P<0 .05) ,but decreased in IDA group(P<0 .05) .The area under the curve of ROC for hepcidin ,SI and TIBC were 0 .97 ,0 .66 and 0 .85 respectively .Conclusion Hepcidin is a simple and safe indicator in differential diagnosis of IDA and ACD ,and its diagnos-tic accuracy is better than SI and TIBC .