2.Diffusion tensor imaging study of Parkinson disease
Hongge SHU ; Jianpin QI ; Wenzhen ZHU ; Chengyuan WANG ; Junwu HU ; Dingyi FENG
Chinese Journal of Medical Imaging Technology 2010;26(4):643-646
Objective To investigate the change of diffusion tensor imaging (DTI) parameters on extracorticospinal tract and some domain in Parkinson disease (PD), and to explore the relationship between DTI parameters and PD. Methods Ten PD patients with unilateral symptoms and 20 with bilateral symptoms were enrolled in PD group 1 and PD group 2, respectively. Control group included 30 volunteers whose age and sex matched with those of PD group. PD patients and the subjects in control group underwent routine MR plain scan and DTI scan. FA and ADC maps were obtained after postprocessing. FA values and ADC values of ROI (region of interest) were measured. ROI included substantia nigra (SN), red nucleus (NR), globus pallidus (GP), putamen (PUT), caudate nucleus (CN), thalamus, genu of corpus callosum, splenium of corpus callosum, callosal gyrus, white matter of frontal lobe and anterior centra gyrus. All data were analyzed statistically. Results FA value of SN, CN, thalamus and splenium of corpus callosum of PD group degraded obviously compared with that of control group (P<0.05). FA value of PD group 1 was lower than control group and PD group 2 at anterior central gyrus and callosal gyrus (P<0.05). There was no significant difference of FA value among PD groups and control group at other ROI's. There was negative correlation between the changes of FA value at SN and PD grade. No significant difference was found in ADC value among PD group 1, PD group 2 and control group, but there was an increasing tendency of ADC value along with the progress of PD. Conclusion FA values of SN, CN, thalamus and splenium of corpus callosum can offer some important information for the early diagnosis of PD. DTI is useful for the study about PD's pathomechanism and clinical manifestation in vivo.
3.Research on resources chemistry of Chinese medicinal materials and resources recycling utilization ways and goals and tasks.
Jin-ao DUAN ; Shu-lan SU ; Sheng GUO ; Shu JIANG ; Pei LIU ; Hui YAN ; Da-wei QIAN ; Hua-xu ZHU ; Yu-ping TANG ; Qi-nan WU
China Journal of Chinese Materia Medica 2015;40(17):3395-3401
The objects of research on the resources chemistry of Chinese medicinal materials (RCCMM) are promotion of efficient production, rational utilization and improving quality of CMM and natural products. The development of TCM cause depends on the efficient utilization and sustainable development of CMM, hinges on the technologies and methods for using and discovering medicinal biological resources, stand or fall on the extension of industy chains, detailed utilizaion of resource chemical components by multi-way, multi-level. All of these may help to the recycling utilization and sound development of RCMM. In this article, five respects were discussed to the RCCMM researches and resources recycling utilization ways and goals and tasks. First, based on the principle of resource scarcity, discovering or replacing CMM resources, protecting the rare or endangered species or resources. Second, based on the multifunctionality of CMM, realizing the value-added and value compensation, and promoting the utilization efficiency through systermatic and detailed exploitation and utilization. Third, based on the resource conservation and environment-friendly, reducing raw material consumption, lowering cost, promoting recycling utilization and elevating utilization efficiency. Fourth, based on the stratege of turning harm into good, using the invasive alien biological resources by multi-ways and enriching the medicial resources. Fifth, based on the method of structure modification of chemical components, exploring and enhancing the utility value of resouces chemical substances. These data should provide references and attention for improving the utilization efficiency, promoting the development of recycling economy, and changing the mode of economic growth of agriculture and industry of CMM fundamentally.
Agriculture
;
economics
;
trends
;
China
;
Conservation of Natural Resources
;
economics
;
trends
;
Drugs, Chinese Herbal
;
chemistry
;
economics
;
Materia Medica
;
chemistry
;
economics
;
Medicine, Chinese Traditional
;
economics
;
trends
;
Plants, Medicinal
;
chemistry
;
growth & development
4.Research practices of conversion efficiency of resources utilization model of castoff from Chinese material medica industrialization.
Jin-Ao DUAN ; Shu-Lan SU ; Sheng GUO ; Pei LIU ; Da-Wei QIAN ; Shu JIANG ; Hua-Xu ZHU ; Yu-Ping TANG ; Qi-Nan WU
China Journal of Chinese Materia Medica 2013;38(23):3991-3996
The industrialization chains and their products, which were formed from the process of the production of medicinal materials-prepared drug in pieces and deep processed product of Chinese material medica (CMM) resources, have generated large benefits of social and economic. However, The large of herb-medicine castoff of "non-medicinal parts" and "rejected materials" produced inevitably during the process of Chinese medicinal resources produce and process, and the residues, waste water and waste gas were produced during the manufactured and deep processed product of CMM. These lead to the waste of resources and environmental pollution. Our previous researches had proposed the "three utilization strategies" and "three types of resources models" of herb-medicine castoff according to the different physicochemical property of resources constitutes, resources potential and utility value of herb-medicine castoff. This article focus on the conversion efficiency of resources model and analysis the ways, technologies, practices, and application in herb-medicine cast off of the conversion efficiency of resources model based on the recycling economy theory of resources and thoughts of resources chemistry of CMM. These data may be promote and resolve the key problems limited the industrialization of Chinese material medica for long time and promote the realization of herb-medicine castoff resources utilization.
Biotransformation
;
Conservation of Natural Resources
;
methods
;
Drug Industry
;
Drugs, Chinese Herbal
;
chemistry
;
metabolism
;
Materia Medica
;
chemistry
;
metabolism
;
Research Design
5.Effects of Folate Deficiency during Pregnancy of Rats on Expression of Foliate Binding Proteins Gene and WNT Signal Transduction Pathway in Heart of Offspring
ru, LIU ; yu-zhu, PENG ; jing, LI ; hu, TONG ; xiao-qi, GU ; shu-ping, HAN ; xi-rong, GUO
Journal of Applied Clinical Pediatrics 2006;0(13):-
Objective To study the expressions of foliate binding protein 1(Folbp1),Wnt and ?-catenin genes on the heart of offspring during the development of embryo,whose mother was deficient of folic acid.Methods Control group involving 18 rats and study group involving 18 rats were choosen from the total 36 adult female SD rats randomly copulate with the male normal rats after feeding different fodder for 2 weeks.The heart of the 13.5,17.5 days embryos and the newborns were obtained.The expressions of Folbp1,Wnt and ?-catenin genes mRNA at the 3 periods were evaluated by RT-PCR.Results The expressions of Folbp1,Wnt and ?-catenin genes mRNA of the study group were significantly weaker than those of the control group in heart of the 13.5,17.5 days embryos and the newborns(all P
6.Clinical effect of arthroscopy-assisted minimally invasive management of bunion.
Hong-liang LI ; Shu-yuan LI ; Wei QI ; Chun-bao LI ; Feng QU ; Guo QI ; Gang ZHAO ; Yu-jie LIU ; Juan-li ZHU
China Journal of Orthopaedics and Traumatology 2016;29(2):138-141
OBJECTIVETo evaluate the effect of arthroscopy-assisted minimally invasive management of bunion and hallux valgus deformities.
METHODSTotal 50 patients (53 feet) with bunion and hallux valgus deformities were treated under arthroscopy from July 2008 to July 2011, with an average age of 42.3 years old (ranging from 30 to 65 years old) involving 19 left feet, 28 right feet and 3 both feet. The American Orthopedic Foot and Ankle Society (AOFAS) hallux metatarsophalangeal-interphalangeal(MP-IP) Scale Score was used to evaluate the therapeutic effect.
RESULTSThere were no complications such as hallux varus, hallux rigid and nerve or blood vessel injury. Clinically, AOFAS MP-IP Scale Score was increased from 62.19 ± 6.01 preoperatively to 88.26 ± 6.81 postoperatively.
CONCLUSIONArthroscopy-assisted minimally invasive management appears to be a good procedure with advantages of less complication, little trauma and early rehabilitation for bunion and hallux valugs deformities.
Adult ; Aged ; Arthroscopy ; methods ; Female ; Hallux Valgus ; surgery ; Humans ; Middle Aged ; Minimally Invasive Surgical Procedures ; methods
7.Preventing scarring in split-thickness skin donor sites with epidermal grafting.
Zhi-xiang ZHU ; Wei-ping LI ; Wei-qi YANG ; Wan-an CHEN ; Feng WANG ; Mei-shu ZHU ; Xiao-guang XU
Chinese Journal of Plastic Surgery 2005;21(6):437-439
OBJECTIVEIntroducing a new technique for preventing the scar growthing in split thickness skin donor sites using the great sheets of epidermis covering.
METHODSThe donor sites of split thickness skin were grafting with the great sheets of the epidermis, of the thickness about 0.07 approximately 0.12 mm, harvested by electrical power dermatome and fixed the edges of the epidermal sheet with the verges of donor wound together using the nanoparticles-Ag-gauze stripes adding the sutures or skin stapler, dressing the wounds with the nanoparticles-Ag-gauze using the tie-over technique, left the dressing entire for a 5-day period.
RESULTSThis method were used in a total of 209 donor sites of both the split-thickness skin and epidermis for 133 reconstructed sites of 118 cases from November 1999 to November 2003, and the smooth, near normal skin appearance without scarring were obtained in the split thickness skin donor sites, and the epidermal donor sites healed good enough 5 days after surgery, and skin appearance is near normal in 3 months later.
CONCLUSIONSCovering the donor sites of split thickness skin with the large sheets of epidermis is an effective and useful method for preventing the scarring in the split thickness skin donor sites.
Adolescent ; Adult ; Child ; Child, Preschool ; Cicatrix ; prevention & control ; surgery ; Female ; Humans ; Male ; Middle Aged ; Reconstructive Surgical Procedures ; methods ; Skin Transplantation ; methods ; Surgical Flaps ; Transplantation, Autologous ; Wound Healing ; Young Adult
8.Determination of ABO blood group genotypes with one tube PCR reaction.
Fei QIN ; Ji HE ; Fa-Ming ZHU ; Jin-Hui LIU ; Shu CHEN ; Qi-Hua FU ; Li-Xing YAN
Journal of Experimental Hematology 2005;13(6):1117-1119
This study was aimed to establish one tube PCR reaction technique to determine ABO blood group genotypes. Salting-out method was adopted to extract genomic DNA; one tube polymerase chain reaction with GeneScan technique was used to identify ABO genotypes. The results showed that the ABO genotypes of 132 samples were in accordance with the phenotypes determined by serological technique. The frequencies of A, B and O were 0.205, 0.159 and 0.636 respectively. AA, AO, AB, BB, BO and OO genotypes were 8 (6.1%), 31 (23.5%), 7 (5.3%), 6 (4.5%), 23 (17.4%), and 57 (43.2%) respectively. It is concluded that one tube polymerase chain reaction with GeneScan technique can determine the genotypes of ABO blood group.
ABO Blood-Group System
;
genetics
;
Gene Frequency
;
Genotype
;
Humans
;
Polymerase Chain Reaction
;
methods
;
Reproducibility of Results
9.Anti-psoriatic effects of honokiol in imiquimod induced mouse model
Qi-Bin ZHONG ; Shu-Guang ZHU ; Shao-Jun LU ; Zhao-Xu CAI ; Lin-Quan ZANG
Chinese Pharmacological Bulletin 2018;34(5):626-631
Aim To explore the anti-psoriatic effects of honokiol on the mouse model induced by imiquimod and the underlying mechanism. Methods The mice were randomly divided into control group, model group, liposome solvent control group, dexamethasone positive group and honokiol high, medium, low dose groups. The progress of the disease was observed by the psoriasis area and severity index (PASI). The morphological changes of the skin cells were observed by HE staining, and epidermis thickness was meas-ured. The expression of IL-17, IL-23, JAK, STAT3, TNF-α and NF-κB was semi-quantitively analyzed by immunohistochemistry. Results Compared to model group, the scaling and thickness of honokiol treated groups were alleviated. Inflammatory infiltration and micro abscess were reduced. The expressions of IL-17, IL-23, JAK, STAT3, TNF-α and NF-κB in model group were higher than those in honokiol-high and honokiol-medium group in a dose-dependent manner. Conclusion Honokiol can inhibit imiquimod-induced psoriasis-like lesions in mice by inhibiting the IL-17/IL-23 inflammatory axis.
10.A case report of atypical placental site nodule
Yi-Jin LIU ; Shu-Jie PANG ; Qi LIU ; Ping-Chuan MA ; Ying-Jun ZHU
Tianjin Medical Journal 2018;46(3):311-313
Placental site nodule as a kind of benign trophoblastic disease is rare.The features of placental site nodule are known very little. Pathological diagnosis is the gold standard, while the pathological features of atypical placental site nodule are known very little. Here we report a case of mass in uterus with atypical placental site nodule, which can supplement our knowledge of this disease.