1.One Case of Buzhong Yiqi Decoction Adding Gardeniae Fructus for Treatment of Acute Suppurative Otitis Media
Chinese Journal of Information on Traditional Chinese Medicine 2018;25(4):120-121
The article mainly discussed the method and prescription of Buzhong Yiqi Decoction adding Gardeniae Fructus for the treatment of acute suppurative otitis media. The author summarized the pharmacological effects, clinical efficacy and application of Buzhong Yiqi Decoction by searching relevant literature,and proposed that weak spleen and stomach and imbalance of yin and yang are the pathogenesis in clinic,which can be treated with Buzhong Yi q i Decoction.
2.Effect of Oral Glucose on Heart Rate of Healthy Newborns
jian, YU ; min-shu, ZOU ; xue-mei, LIU ; guo-ming, NIE
Journal of Applied Clinical Pediatrics 2006;0(15):-
0.05).The change of heart rate in 2 groups was greater than that of distilled water respectively(P
3.Influence of Losartan on Transforming Growth Factor-?1 and Connective Tissue Growth Factor in Rats with Diabetic Nephropathy
jian, YU ; min-shu, ZOU ; xue-mei, LIU ; guo-ming, NIE ; jing, LIU
Journal of Applied Clinical Pediatrics 2006;0(20):-
Objective To investigate expression of transforming growth factor-?1(TGF-?1)and connective tissue growth factor(CTGF) protein in renal tissues,and detect the levels of urinary TGF-?1 and CTGF in rats with diabetic nephropathy(DN).To observe the influence of losartan on expression of the two protein in renal tissue and excretion in urine.Methods Wistar rats were treated by intravenous injection of streptozotocin after right nephrectomy to induce DN rat model.The DN rats were randomly divided into two groups:DN experimental group and losartan treated group.The expression of TGF-?1 and CTGF in renal tissue were determined with immunohistochemical staining,urinary TGF-?1 and CTGF were assayed by enzyme-linked immunosorbent assay(ELISA) at 6,12 weeks respectively.Results Compared with losartan treated group,urinary protein excretion and the protein expression of TGF-?1 and CTGF significantly increased(P
4.Relative factors in home safety evaluated by multilevel statistical models
Shu-Mei WANG ; Jin-Liang ZOU ; Wen-Yan XU ; Ming-Min YIN
Chinese Journal of Epidemiology 2010;31(9):975-978
Objective To understand the situations of home establishments and the related domestic behaviors that causing injuries. Methods A total of 9760 families with regular residents in a community in Shanghai were investigated. Questionnaire was designed bascd on the Guidelines for Conducting Community Surveys on Injuries and Violence and International Classification of External Causes of Injuries. Results Inside the home settings, relative factors were found on issues as fire protection and using of electricity. In terms of household settings, 14.85% of the families had smoke alarm systems in the kitchen; 40.75% had no windows set for emergence. 50% to 70% of the residents had the idea of safe behaviors, including 35.93% of the families stored cleaning products,other chemicals or medical substances in alternative containers, such as used drinking bottle. Only 1.81% of the people being investigated thought that home was also a high risk place where injury might occur and it was placed number 9 in a multiple choice questionnaire. Data from the multiple level model analysis showed that factors as number of family members, space, education, profession etc. were closely related to the situation of home settings and their resident's behaviors. Conclusion Many injury related factors were found related to home establishments and people' s daily behaviors at home which called for interventions to be taken.
5.Review on the etiological property of 1957 Asian flu virus (H2N2).
Ning DU ; Xiao-Xing YANG ; Lei YANG ; Yu-Hong ZENG ; Shu-Mei ZOU ; Hong BO ; Yuan-Ji GUO ; De-Xin LI ; Yue-Long SHU
Chinese Journal of Virology 2009;25 Suppl():12-16
6.Identification of melatonin receptor in human embryonic peripheral tissue
Zhi-Min LIU ; Jun-Jie ZOU ; Yu-Mei SHEN ; Zu-Qian LU ; Shu-Fen HE ; Shu-Xun PENG
Academic Journal of Second Military Medical University 2001;22(1):8-11
Objective: To determine protein binding characteri stic and signal transmission pathway of melatonin(Mel) receptor(MR) in human e mbryonic peripheral organ tissues. Methods: MR was measured by radio ligand-binding assay and the effect of GTPγS on melatonin specific bindi ng was studied. Results: Mel specific binding sites were det ermined in 16 kinds of human embryonic tissue and this binding could be inhibit ed by GTPγS, supporting the theory that MR is coupled to inhibitory G-proteins system. Conclusion: MR is measured in human embryo tissue, the se results provide experimental data for elucidating the mechanism of the effect of Mel.
7.Short-term efficacy of sevelamer hydrochloride on hyperphosphatemia in patients undergoing maintenance hemodialysis
Yi FANG ; Xiaoqiang DING ; Jianzhou ZOU ; Yan FANG ; Jiaqi QIAN ; Shu RONG ; Changlin MEI ; Qiang QIU ; Xiangmei CHENG ; Zhihua ZHENG ; Xueqing. YU
Chinese Journal of Nephrology 2012;28(3):183-188
Objective To evaluate the short-term efficacy and safety of sevelamer hydrochloride in treating maintenance hemodialysis (MHD) patients with hyperphosphemia.Methods A multicenter,open-labeled,self-control study was performed.Phosphate binders were discontinued during a two-week washout period.Patients with more than 1.78 mmol/L serum phosphorus after two-week washout period were eligible for the trial.The dose was adjusted every two weeks as necessary to achieve serum phosphorus control. Sevelamer hydrochloride was administered to 138 MHD patients for 10 weeks and a second two-week washout period followed.Results A total of 111 from 138 patients fulfilled the whole 14-week study. Mean serum phosphorus and calcium-phosphate products starte to decline after two-week sevelamer hydrochloride treatment. By the end of 10-week sevelamer hydrochloride treatment, mean serum level of phosphorus [(1.85±0.50) vs (2.57±0.54) mmol/L,P<0.01],calcium-phosphate product [(4.16± 1.72) vs (5.79 ± 1.50) mmol2/L2,P<0.01 ] and low density lipoprotein [(1.64±0.76) vs (2.31 ±0.87) mmol/L,P<0.01] were significantly decreased,while the adjusted serum level of calcium and serum intact parathyroid hormone kept steady.Both serum phosphorus and calcium-phosphrus product increased after the second washout period, but the levels were still lower as compared to pre-treatment [(2.26±0.71) vs (2.57±0.54) mmol/L; (5.12±1.63) vs (5.79±1.50) mmol2/L2,P<0.01].Of the 138 patients involved,214 episodes in 106 patients and 121 episodes in 89 patients were reported as adverse events and adverse drug reaction respectively. Gastrointestinal symptoms,of which most were mild or moderate,happened to 68.1% (94/138) patients. Conclusions Sevelamer hydrochloride can control serum phosphorus and reduce the levels of calcium-phosphorus product and cholesterol.Slight gastrointestinal symptoms like constipation are common during the treatment.
8.Study of clinical outcome and analysis of prognosis related factor in children with acute myeloid leukemia.
Yao ZOU ; Hua WANG ; Xiao-Juan CHEN ; Shu-Chun WANG ; Li ZHANG ; Yu-Mei CHEN ; Xiao-Fan ZHU
Chinese Journal of Hematology 2006;27(9):621-625
OBJECTIVETo analyse the clinical outcome and the prognostic factor of childhood acute myeloid leukemia (AML).
METHODSDisease-free survival (DFS), event-free survival (EFS) and overall survival (OS) rates were estimated by Kaplan-Meier method and prognostic factors were evaluated by Cox regression with SPSS in 141 childhood AML in our hospital from August 1995 to July 2004. The patients were divided into 2 groups: acute promyelocytic leukemia (APL) as group A and AML other than APL as group B.
RESULTSOf the 90 group B patients, 54.4% (49/90) achieved complete remission (CR) after one course chemotherapy , with a total CR rate of 76.7%. The cumulative 5 year DFS and OS rate for group B patients were (28.4 +/- 9.0)% and (35.5 +/- 6.3)%, the 51 group A patients were (94.3 +/- 4.0)% and (81.4 +/- 5.7)%, and for total 141 AML patients were (56.9 +/- 6.3)% and (53.3 +/- 4.8)% respectively. Multivariate analysis demonstrated that higher bone marrow blast cell percentage at diagnosis, CR after more than one course of chemotherapy and less than six courses of consolidation chemotherapy were risk prognostic factors in childhood AML other than APL (P < 0.05).
CONCLUSIONThe prognosis of childhood APL is better, while of childhood t(8;21) AML is no better than other FAB subtypes.
Adolescent ; Bone Marrow Cells ; cytology ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Infant ; Leukemia, Myeloid, Acute ; mortality ; therapy ; Male ; Prognosis ; Regression Analysis ; Retrospective Studies ; Treatment Outcome
9.Investigation of GSTT1, GSTM1 and NQO1 genes polymorphisms in myelodysplastic syndromes.
Lin YANG ; Xu ZOU ; Mei-rong ZHANG ; Yue ZHANG ; Yu-shu HAO ; Zhi-jian XIAO
Chinese Journal of Hematology 2005;26(11):674-677
OBJECTIVETo investigate the relationship between GSTM1, GSTT1 and NQO1(C609T) genotypes and myelodysplastic syndromes (MDS) susceptibility and chromosome abnormalities.
METHODSGSTT1, GSTM1 and NQO1(C609T) genotypes were detected in 52 MDS patients and 241 unrelated controls by PCR or PCR-RFLP.
RESULTSThe incidence of GSTT1 and GSTM1 null genotype was significantly increased in MDS patients as compared with controls (P = 0.001 and P < 0.001, respectively). In individuals with GSTT1 and GSTM1 null genotype, the odds ratios for MDS risk were elevated to 2.873 (95% CI: 1.491-5.537) and 3.591 (95% CI: 1.717-7.508), respectively. A significantly increased frequency of GSTT(1) null genotype among MDS patients with normal karyotype and increased frequency of GSTM1 null genotype among MDS patients with chromosome abnormalities were found as compared to controls (OR = 5.336, P = 0.005 and P = 0.003, OR = 3.740, respectively). There was no difference in the incidence of NQO1(C609T) genotypes between MDS patients and controls.
CONCLUSIONDetermination of the GSTM1 and GSTT1 genotypes may be used as a stratification marker to predicate high-risk individuals for MDS.
Adolescent ; Adult ; Aged ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase ; genetics ; Humans ; Male ; Middle Aged ; Myelodysplastic Syndromes ; genetics ; NAD(P)H Dehydrogenase (Quinone) ; genetics ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length
10.Morphological study and Ca/P ratio analysis of Er, Cr:YSGG laser irradiation on periodontal diseased root surfaces.
Shu-ping SUN ; Ya-ping PAN ; Dong-mei ZHANG ; Bo ZOU
West China Journal of Stomatology 2006;24(5):444-446
OBJECTIVETo observe the morphological transformation and Ca/P changes of the periodontally disease root surfaces irradiated by Er, Gr:YSGG Laser.
METHODS18 periodontally diseased teeth and 6 wisdom teeth were collected in vitro. After 18 periodontally diseased teeth were planed, 12 teeth were randomly selected as the laser treatment group, the others as the acid treatment group. The 6 wisdom teeth were selected as the healthy control. Then the evaluation for root surfaces morphological transformation was conducted by SEM. An energy spectrum analyzer was used to analyze the Ca/P ratio of root surfaces.
RESULTSThe root surfaces were clean and even in the laser treatment group. Smear layer could also be effectively eliminated in the laser treatment group and the acid treatment group, but the SEM results were different. Atom content analysis showed that the Ca/P ratio of the laser treatment group and the acid treatment group had no distinct difference.
CONCLUSIONIt is effective to remove smear layers and infected cementum of surface layers with Er, Cr:YSGG irradiating on the planed periodontal root surfaces.
Cell Adhesion ; Dental Cementum ; Humans ; Lasers, Solid-State ; Microscopy, Electron, Scanning ; Periodontal Diseases ; Root Planing ; Smear Layer ; Tooth Root