1.Orbitofrontal cortex action of 5-hydroxytryptamine, glutamate and nitric oxide in an acute forced swimming stress-induced depression model.
Chinese Journal of Applied Physiology 2011;27(4):474-I
Animals
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Depression
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etiology
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metabolism
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Frontal Lobe
;
metabolism
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Glutamic Acid
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metabolism
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Male
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Nitric Oxide
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metabolism
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Rats
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Rats, Sprague-Dawley
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Serotonin
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metabolism
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Stress, Physiological
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physiology
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Swimming
5.Effects of ginkgolide (Gin) on cerebral water content, Na+, K(+) -ATPase activity, MDA, lactic acid of rats during acute hypoxia condition.
Jian-Cheng LI ; Shu-Yi JIN ; Xiao-Mei WU
Chinese Journal of Applied Physiology 2003;19(3):239-273
Animals
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Brain
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metabolism
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Female
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Ginkgolides
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pharmacology
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Hypoxia
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metabolism
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Lactic Acid
;
metabolism
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Male
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Malondialdehyde
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metabolism
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Rats
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Rats, Sprague-Dawley
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Sodium-Potassium-Exchanging ATPase
;
metabolism
6.Changes of plasma ghrelin concentrations after oral glucose loading in obese children.
Ge-li LIU ; Shu-ying WANG ; Xian-cheng MA
Chinese Journal of Pediatrics 2007;45(7):543-544
Adolescent
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Child
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Female
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Ghrelin
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blood
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Glucose
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pharmacology
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Humans
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Male
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Obesity
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blood
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Time Factors
8.Progress in the study of tubulin inhibitors.
Hai SHANG ; Li PAN ; Shu YANG ; Hong CHEN ; Maosheng CHENG
Acta Pharmaceutica Sinica 2010;45(9):1078-88
Microtubule is one of the key components of the cytoskeleton and plays an important role in the maintenance of cell shape and the process of signal transduction and mitosis. Due to the extreme importance of microtubule in the process of mitosis, tubulin becomes one of the most important targets for development of new anticancer drugs and tubulin inhibitors are used for the treatment of cancer nowadays. These inhibitors have antitumor activity by inhibiting or promoting the assembly of tubulin to microtubules and interfering the process of cell mitosis. This review summarized the research progress of the tubulin inhibitors, especially the introduction of the tubulin inhibitors of pharmacological activities and the progress of clinical research. Also, the development trend of these inhibitors is discussed.
9.Analysis of Interleukin-1 Recepetor Antagonist Gene Polymorphisms of Children with Febrile Seizwres
shu-hua, LI ; chao-feng, HU ; wen-cheng, MA
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To evaluate the relationship between children interleukin-1 receptor antagonist gene(IL-1RN) polymorphisms and susceptibility to febrile seizures(FS).Methods Matching case-control study was carried out,blood samples from 52 patients with FS and 53 healthy children were collected.Genomic DNA was extracted and examined by polymerase chain reaction(PCR) amplification for judging IL-1RN genetype.Results Only Ⅰ/Ⅰ,Ⅰ/Ⅱ,Ⅱ/Ⅳ genetypes of IL-1RN were found in the surveyed Chinese population of Han nationality in Guangdong Province.No significant differences of these genotypes were observed in patients and controls.But the allele frequencise of Ⅰ,Ⅱand Ⅳ in patients were 95.2%,3.8% and 1.0%,respectively,while these frequencise in controls were 84.9%,10.4% and 4.7%,respectively.The allele frequency of IL-1RNⅠin patients was obviously higher than that in controls(P
10.Expression of Vascular Endothelial Growth Factor and Its Receptor of Bone Marrow in Children with Acute Leukemia
shu-jun, LI ; tai-xin, SHI ; cheng-he, TANG
Journal of Applied Clinical Pediatrics 2006;0(15):-
Objective To investigate the expression of vascular endothelial growth factor/vcascular endothelial growth factor receptor(VEGF/VEGFR) in bone marrow of children with acute leukemia(AL),and explore their relationship of the clinical features,and observe changes before and after chemotheropy.Methods The bone marrows of 53 children with AL were assayed to study the expression of VEGF/VEGFR(KDR,Flt-1)before and after chemtheropy with S-P immhistochemical staining.Their relations to the clinical features were evaluated.Results The expressions of VEGF,Flt-1,KDR were significantly higher in newly diagnosed children with AL than those of control group.They were significantly higher in children with acute myeloid leukemia(AML) than in children with ALL.The expressions of VEGF,Flt-1,KDR in remission chidren after chemotheropy were significantly lower than before chemotheropy.There was a positive correlation of the percentage of bone marrow blasts with VEGF expression in children with AL.There was also a positive correlation of the percentage of leukemic cell in blood rountine with VEGF expression.For the untreated group of children,no correlation was found between expressions of VEGF,Flt-1,KDR and age,sex,extramedullary infiltration.Conclusions Expression levels of VEGF,Flt-1,KDR in bone marrow of children with AL increases.VEGF/VEGFR may play an important role in process of chidhood AL.