We report a case of rhinocerebral mucormycosis in a 31 year
old immunocompetent female presenting initially like acute
rhinosinusitis with nasal stuffiness, severe headache,
vomiting who soon developed isolated right lateral rectus
palsy. Computed tomography(CT) scan of the Post-Nasal
Spaces(PNS) showed an ill defined expansile heterogenous
density mass in the sphenoid with extension into the
ethmoids, nasal cavity, optic canal, superior orbital fissure, clivus and right temporal lobe with signal void in Magnetic Resonance Imaging(MRI). The debris and polypoid mucosa obtained on nasal endoscopy revealed mucormycosis on histopathologic examination. The patient was managed with urgent surgical debridement and medical management.