1.Study on Anti-Proliferative Activities of Cultured Cordyceps Militaris on Cancer Cells
Msayuki HIGASHINO ; Hiroshi HORIE ; Masakatu ITO ; Keiko TANAKA ; Yasuki FUKUDA ; Shozo NISHIDA ; Kazuya MURATA ; Hideaki MATSUDA
Japanese Journal of Complementary and Alternative Medicine 2013;10(1):51-57
Cordyceps militaris has been known to produce an anticancer agent, cordycepin. Investigation on optimum culture condition for C. militaris had been performed. In the research program for discovering a novel function in the culture of C. militaris, the culture media was applied to a proliferation assays using various cell lines. The media showed significant anti-proliferative activities against al cell lines, especially to human leukemia cell line HL-60. The activity-guided purification of active ingredient was performed to obtain uracil. To the best of our knowledge, uracil has not been reported to possess anti-proliferative activity. However, the uracil obtained from the culture media was subjected to ICP-MS analysis to reveal that sodium, potassium and magnesium were found to co-exist with uracil, which might show anti-proliferative activity. Further study on the mechanism of the expression of the activity is now underway.
2.Comparative study on the myocardial protection during cardiac surgery for adult patients with coronary or valvular heart diseaseAssessment of enzyme activity level in serum.
Masayoshi Okada ; Shozo Matsuda ; Kazunori Shio ; Keikichi Nishida ; Yoshiaki Hamaoka ; Shuichi Kozawa ; Tsutomu Shida ; Masayuki Matsumori ; Kazuo Nakamura
Japanese Journal of Cardiovascular Surgery 1984;14(3):166-168
3.Survey on Customer Satisfaction for Evaluation and Improvement of Physical Assessment Practical Training Seminar for Pharmacists
Toru Otori ; Tomomi Inoue ; Koichi Hosomi ; Hiroyuki Nakagawa ; Keiko Takashima ; Hisami Kondo ; Tsugumi Takada ; Eiji Ito ; Takashi Nakayama ; Tetsuyuki Wada ; Shunji Ishiwata ; Tomohiro Maegawa ; Yoshinori Funakami ; Shinya Nakamura ; Yoshie Kubota ; Atsushi Hiraide ; Kenji Matsuyama ; Shozo Nishida
Japanese Journal of Social Pharmacy 2016;35(2):94-101
In the areas of home medical care and self-medication, the role of the pharmacist is growing, partly as a result of Japan’s aging society and the need to reduce medical costs. In response, the Kinki University Faculty of Pharmacy implemented a physical assessment practical training seminar in order to improve the physical assessment skills of practicing pharmacists. A series of questionnaires were conducted among pharmacists to investigate their perceptions of physical assessment practical training seminars. The results of the questionnaires were analyzed using Customer Satisfaction (CS) analysis and text mining. Based on a 5-point scale (1-low∼5-high), questionnaires revealed satisfaction for physical assessment practical training seminars was 4.6±0.6 (Ave.±S.D.). CS analysis revealed that the items “lectures” and “case seminars” had the highest level of satisfaction. However, items showing low levels of satisfaction were “auscultation of respiratory sounds” and “SBAR (Situation, Background, Assessment, Recommendation).” Results of text mining suggested a relationship between “physical assessment” and “difficult”. Analysis of the questionnaires showed a high level satisfaction with physical assessment practical training seminars, notably physical assessment practice methods. However, CS analysis and text mining indicate the finer techniques of physical assessment were difficult to acquire.
4.Comparison of the Perception between Pharmacy Students and Practicing Pharmacists in the Acquisition of Physical Assessment Skills
Toru OTORI ; Tomomi INOUE ; Koichi HOSOMI ; William FIGONI ; Manabu KITAKOJI ; Hiroko HACHIKEN ; Hiroyuki NAKAGAWA ; Keiko TAKASHIMA ; Hisami KONDO ; Tsugumi TAKADA ; Kenji MATSUYAMA ; Shozo NISHIDA
Japanese Journal of Social Pharmacy 2018;37(2):127-133
The expansion of home medical care and the growth in sales of OTC, coupled with Japan’s aging society and the need to reduce medical costs has broadened the role of the pharmacist to include physical assessment. In response, the Kindai University Faculty of Pharmacy, implemented the Physical Assessment Practical Training Course (PAPTC) to improve the physical assessment skills of pharmacy students and practicing pharmacists. In order to investigate pharmacy students’ and practicing pharmacists’ perceptions of PAPTC, a questionnaire using a five-part, forced- choice Lykert type scale was conducted. The results of the questionnaire were analyzed using factor analysis and cluster analysis. The total number of respondents was 456. Three hundred thirteen of the respondents were students, and 143 of the respondents were practicing pharmacists. Factor analysis revealed four factors which we titled, “Physical Assessment Skills”, “Physical Assessment Course”, “Pharmacist Jobs” and, “Knowledge Required by Pharmacist”. Subsequently, cluster analysis identified two distinct groups. Group A which constituted primarily of pharmacy students, and Group B which consisted primarily of practicing pharmacists. Each group displayed notable differences in perceptions related to PAPTC. These differences may be influenced by perceptions toward “skills” and/or “knowledge”. These findings suggest that in order to better address the motivational needs of the participants, PAPTC should be divided into two courses. One, for knowledge-based instruction, and other for skill-based practice.
5.Comparison of the Perception between Pharmacy Students and Practicing Pharmacists in the Acquisition of Physical Assessment Skills
Toru OTORI ; Tomomi INOUE ; Koichi HOSOMI ; William FIGONI ; Manabu KITAKOJI ; Hiroko HACHIKEN ; Hiroyuki NAKAGAWA ; Keiko TAKASHIMA ; Hisami KONDO ; Tsugumi TAKADA ; Kenji MATSUYAMA ; Shozo NISHIDA
Japanese Journal of Social Pharmacy 2018;37(2):127-133
The expansion of home medical care and the growth in sales of OTC, coupled with Japan’s aging society and the need to reduce medical costs has broadened the role of the pharmacist to include physical assessment. In response, the Kindai University Faculty of Pharmacy, implemented the Physical Assessment Practical Training Course (PAPTC) to improve the physical assessment skills of pharmacy students and practicing pharmacists. In order to investigate pharmacy students’ and practicing pharmacists’ perceptions of PAPTC, a questionnaire using a five-part, forced- choice Lykert type scale was conducted. The results of the questionnaire were analyzed using factor analysis and cluster analysis. The total number of respondents was 456. Three hundred thirteen of the respondents were students, and 143 of the respondents were practicing pharmacists. Factor analysis revealed four factors which we titled, “Physical Assessment Skills”, “Physical Assessment Course”, “Pharmacist Jobs” and, “Knowledge Required by Pharmacist”. Subsequently, cluster analysis identified two distinct groups. Group A which constituted primarily of pharmacy students, and Group B which consisted primarily of practicing pharmacists. Each group displayed notable differences in perceptions related to PAPTC. These differences may be influenced by perceptions toward “skills” and/or “knowledge”. These findings suggest that in order to better address the motivational needs of the participants, PAPTC should be divided into two courses. One, for knowledge-based instruction, and other for skill-based practice.