Objective To investigate the clinical diagnostic value of electrocardiogram(ECG)in patients with low blood potassium.Methods From January 2015 to October 2015,patients with low blood potassium were given ECG examination in Yueqing Maternal And Child Health Care Hospital.The relationship between low blood potassium and ECG changes was analyzed.Results The concentration of serum potassium in patients with 0.9 -2.5mmol/L electrocardiogram U wave change,T wave change,ST segment changes,Q -T prolongation,arrhythmia were significantly higher than that of serum potassium concentration in 2.6 -3.4mmol/L patients,and the difference was statistically significant (χ2 =4.63,4.10,4.47,5.01,4.92,all P <0.05).Of patients with hypokalemic ECG showed characteristics of U wave amplitude increased,ST segment depression,T wave amplitude decreased,QT interval prolongation,arrhythmia,of which the most common was premature ventricular contractions,severe low blood potassium could also be occurrence of malignant ventricular arrhythmia.Conclusion Low blood potassium has characteristic changes of ECG,ECG as a noninvasive,simple and quick examination,which is helpful for the rapid diagnosis of low blood potassium.

OBJECTIVETo study the variation in plasma concentration after oral administration of Danshen multi-component osmotic pump tablets in Beagle dogs with conventional Danshen tablets as the control preparation, in order to assess the sustained release of Danshen multi-component osmotic pump tablets.

METHODHPLC was adopted for determination, with Shimadzu's ODS-SP column (4.6 mm x 150 mm, 5 microm), flow rate of 1 mL x min(-1), and column temperature of 30 degrees C. Protein in plasma samples of tanshinone II(A) and salvianolic acid B was removed by ethyl acetate extract and acetone precipitation method respectively. Their pharmacokinetic parameters were calculated based on determination results.

RESULTThe methodology study on the two constituents with different polarity showed conformity to the requirements. Compared with conventional Danshen tablets, Danshen multi-component osmotic pump tablets showed decrease in Cmax and extension in Tmax after oral administration in Beagle dogs.

CONCLUSIONDanshen multi-component osmotic pump tablet has a good sustained-release effect compared with conventional Danshen tablets.

Animals ; Dogs ; Drugs, Chinese Herbal ; pharmacokinetics ; Male ; Osmosis ; Salvia miltiorrhiza ; chemistry ; Tablets ; Time Factors

OBJECTIVETo study the absorption mechanism of tanshinones in the roots of Salvia miltiorrhiza as well as the interaction between the components in the effective fraction.

METHODThe model of intestinal absorption in vivo was used and the concentrations of the tanshinones were determined by HPLC, the apparent absorption constant (K(a)) and half life of absorption (t1/2) were obtained, the other components in the extract on the absorption of the there components were also studied.

RESULTWith the increase of dosage of tanshinone II A or cryptotanshinone, K(a) decreased and absorption half life t1/2 increased, the drug absorption rate constant (K(a)) had little significant effect on duodenum, Jejunum and ileum. Tanshinone I has a good absorbing in the rat small intestine. The absorption of tanshinone II A and cryptotanshinone was promoted by the other components in tanshinones extract while tanshinone I' was decreased.

CONCLUSIONWhen the concentration increases to a certain level, the uptake of tanshinone II A and cryptotanshinone do not increase. The transport mechanism of tanshinone II A and cryptotanshinone in vivo is similar to active transport or facilitated diffusion. They could be well absorbed in general intestinal tract without specific absorption site, and the complex constituents in extract could significant effect the absorption of the pharmaceutical effective constituents.

Absorption ; Animals ; Diterpenes, Abietane ; Drugs, Chinese Herbal ; analysis ; pharmacokinetics ; Intestine, Small ; drug effects ; physiology ; Male ; Phenanthrenes ; analysis ; pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Salvia miltiorrhiza ; chemistry

AIM: To study the inhibitory effect of Xihuang Pill on H

Objective To explore the safety of minimally invasive esophagectomy (MIE) with three-field lymphadenectomy (3-FL) for esophageal squamous cell carcinoma (ESCC) by comparing the short-term outcomes between the 3-FL and the two-field lymphadenectomy (2-FL) in MIE. Methods The clinical data of patients with ESCC who underwent minimally invasive McKeown esophagectomy in our hospital from July 2015 to March 2022 were collected retrospectively. Patients were divided into a 3-FL group and a 2-FL group according to lymph node dissection method. And the clinical outcomes and postoperative complications were compared between the two groups. Results A total of 257 patients with ESCC were included in this study. There were 211 males and 46 females with an average age of 62.2±8.1 years. There were 109 patients in the 3-FL group and 148 patients in the 2-FL group. The operation time of the 3-FL group was about 20 minutes longer than that of the 2-FL group (P<0.001). There was no statistical difference between the two groups in the intraoperatve blood loss (P=0.376). More lymph nodes (P<0.001) and also more positive lymph nodes (P=0.003) were obtained in the 3-FL group than in the 2-FL group, and there was a statistical difference in the pathological N stage between the two groups (P<0.001). But there was no statistical difference in the incidence of anastomotic leak (P=0.667), chyle leak (P=0.421), recurrent laryngeal nerve injury (P=0.081), pulmonary complications (P=0.601), pneumonia (P=0.061), cardiac complications (P=0.383), overall complications (P=0.147) or Clavien-Dindo grading (P=0.152) between the two groups. Conclusion MIE 3-FL can improve the efficiency of lymph node dissection and the accuracy of tumor lymph node staging, but it does not increase the postoperative complications, which is worthy of clinical application.