1.CROSS--SECTION AREAS AND VOLUMES OF THE SPINAL CORD SEGMENTS OF CHINESE
Keren ZHANG ; Shouxiang LU ; Jingzhong ZHENG
Acta Anatomica Sinica 1955;0(03):-
The segment length,the length of dorsal root attachment of each segment of the spinal cord of 10 adult men were measured.The cross sections from 4 specimens were stained with 1% osmic acid and the area of each section was measured with a com- pensating polar planimeter after being magnified 10 diameters.The segment volume was obtained by multiplying the segment length by the cross-sectlon area. The results shows that the length of spinal cords in Chinese are essentially the same as those from European and Japanese.They are approximately 44cm.in length. The length of each part of the cord in Chinese,European and Japanese were compared. The length of each part of the cord in Chinese and European are essentially alike,but the length of lumbar cord of Japanese appears to be slightly longer. The results show that the weight of the segment was closely related to the segment length. The coronal diameter of each segment is longer than the sagittal diameter,especial- ly it is true in the cervical enlargement.The longest coronal and sagittal diameters are found in the cervical enlargement,the next are in the lumbar enlargement,and the shortest are in the thoracic segment. The volume of the cervical segment and the lumbo-sacral segment is closely rela- ted to their cross-section area particularly to the area of their white matter. The volume of the gray matter of the cervical and the lumbo-sacral segments has a close relation to the gray matter area of the same segment,but that of the thoracic segment is related to its length. It is quite obvious that the volume of the white matter of both the cervical and lumbar enlargements reaches its highest value at segments higher than that of the gray matter,which may indicate that the increase in volume in the gray and white matter are dependent upon each other.
2.THE SEGMENTAL DISTRIBUTION OF THE AFFERENT NERVES OF THE CAECUM AND TSUSANLI REGION IN RABBITS——A STUDY WITH THE HORSERADISH PEROXIDASE METHOD
Zhendong XUE ; Shouxiang LU ; Changsheng YUE ; Ming ZHAO ; Jianguang HE ;
Acta Anatomica Sinica 1955;0(03):-
Ten adult rabbits (7 and ♀3; body weights 1.5~2 kg) were selected for thee present study. A solution of 2~10% HRP (RZ=2.9) was injected into the subserosa of the caecum in seven rabbits and a solution of 5~10% HRP into the deep peroneal nerve of Tsusanli (足三里) region in the other three. The uptake and retrograds transmission of HRP in the afferent fibres of both the somatic and visceral nerves were traced to the spinal ganglia. The range of segments where the neurons from which these two afferent fibres originate overlap each other. The results are a follows:1. Labelled sensory neurons from the region of the caecum where HRP was injected are observed in the spinal ganglia C_8~S_3 with a higher concentration in T_(11)~L_2.2. Labelled neurons from the region of Tsusanli are found in the spinal ganglia L_1~S_3 with a higher concentration in L_6~S_2.3. The ranges of distribution of labelled neurons from the two groups of afferent fibres overlap in the segments L_1~S_3.4. Most of the labelled cells are small and medium in size and the Iabelled cells are found more concentrated in the lumbosacral segments.
3.ORIGINS OF THE AFFERENTS TO THE HIPPOCAMPUS IN THE RAT——HRP METHOD
Shouxiang LU ; Zhendong XUE ; Ming ZHAO ; Jianguang HE
Acta Anatomica Sinica 1955;0(03):-
The afferent projections to the hippocampus were studied with HRP. Thirty three per cent solution of HRP was slowly injected into the dorsal or ventral hippocampus on its right side in 25 albino rats and HRP-labelled cells were found in the following nuclei:1. On the ipsilateral side: entorhinal cortex, medial septal nucleus, supramammillary nucleus, submammillothalamic nucleus, dorsal raphe nucleus, median raphe nucleus, locus coeruleus, diagonal band and nucleus of superior colliculus.2. On the contralateral side: areas CA_3 and CA_4 of hippocampus and locus coeruleus.
4.High sensitive Serum C-reaction protein in macrovascular disease with or without type 2 diabetes
Hongwen LU ; Yinhuan ZHANG ; Lin LIU ; Shouxiang SHEN ; Xiangfeng MENG
Chinese Journal of Rehabilitation Theory and Practice 2005;11(5):393-394
ObjectiveTo observe the changes of high sensitive serum C-reaction protein (hsCRP) in macrovascular disease with or without type 2 diabetes.MethodsThere were 3 groups population in our study:148 type 2 diabetic patients were divided into 2 subgroups:77 patients with macrovascular disease and 71 without macrovascular disease, 73 non-diabetic patients with macrovascular disease and 75 health controls. The concentration of serum hsCRP of all patients were determined by ELISA.ResultsThere was significant difference in concentration of serum hsCRP between type 2 diabetes with or without macrovascular disease groups, non-diabetes macrovascular disease group and control(P<0.01 or P<0.001). However, there was not significant difference between 2 diabetes groups and non- diabetic macrovascular disease group(P>0.05). There was no significant difference in hsCRP between type 2 diabetes with and without macrovascular disease (P>0.05).ConclusionThere may be a chronic inflammatory reaction in patients with type 2 diabetes or macrovascular disease. hsCRP might be a well forecasting factor of the occurrence and development of type 2 diabetes and atherosclerosis.
5.Investigation and Analysis of Medication Information Labeling in 157 Package Inserts of Anticancer Drugs
Jing MA ; Yan WANG ; Bo LU ; Shouxiang TANG ; Lihua YUAN ; Xuemin ZHOU
China Pharmacy 2019;30(7):985-990
OBJECTIVE: To investigate and analyze medication information labeling in package inserts of anticancer drugs, and to provide reference for clinical rational use. METHODS: The package inserts of anticancer drugs were collected from drug catalogues of 3 Third Grade Class A hospitals in Nanjin. Common problems of drug package inserts (whether the main contents arweree contradictory or not and whether the contents were fully expressed, etc.), complete specific labeling items (detailed contents of “ADR” “contraindication” “precautions” and other items), detailed intravenous injection dispensing guidance (solvent selection, precautions during dispensing, etc.), package insert labeling difference of drugs with same general name and route of administration were evaluated according to Drug Package Inserts and Label Management Regulation,Regulations for Chemical Drugs and Biological Products for Treatment. RESULTS: A total of 157 package inserts for anticancer drugs were collected and divided into domestic drugs (80 pieces) and imported drugs (77 pieces) according to the source as well as also divided into oral preparation (44 pieces) and injection (113 pieces). The common problems of package inserts for anticancer drugs contained contradictory main contents, incomplete description, Chinese character errors, missing items and simple description of drug interactions, etc. Compared with domestic or oral anticancer drugs, the labeling rate of each item in the import or injection anticancer drug package inserts was higher, but specific labeling items such as prevention and treatment of vomiting (<20%) under “precautions” and interference of drugs on clinical tests (<40%) were lower. The labeling rate of serious ADR after large dose or long-term use was all less than 41% under the item of “drug overdose” (except for imported drugs). The labeling rate of intravenous dispensing guidance of imported anticancer drug injection package inserts about preparations was higher than that of domestic ones. There were differences in labeling items as “precautions” (30/56,53.57%), “pharmacological toxicology” (29/56,51.79%), “contraindication” (26/56,46.43%) among 56 groups of drug package inserts with same general name and route of administration. CONCLUSIONS: The labeling items for drug package inserts of anticancer drugs need to be further standardized and improved. It is recommended that the relevant departments force pharmaceutical manufacturers to regularly supplement the deficiencies in the package inserts to improve the safety of drug use in clinic.