Objective To investigate indications of video-assisted thoracoscopic surgery in the treatment of esophageal carcinoma.Methods Video-assisted thoracoscopic surgery was performed in 11 patients with esophageal carcinorma from January 2005 to November 2005.The tumors were located at the upper segment in 2 patients,middle segment in 8 patients,and lower segment in 1 patient.The TNM staging results showed T_1N_0M_0 in 1 patient,T_2N_0M_0 in 2 patients,T_2N_1M_0 in 1 patient,and T_3N_0M_0 in 7 patients.Under thoracoscopy via thoracic and cervical incisions,the esophagus and tumor were disconnected and the intrathoracic lymph nodes were cleared through the right thorax.Then a median incision was made at the epigastrium.Through the incision the stomach was disconnected and intraabdominal lymph nodes were removed.Afterwards,esophagectomy and gastroesophagostomy were performed by way of the cervical incision.Results The operation time was 220~300 min(mean,265 min).The operative blood loss was 150~400 ml(mean,240 ml).The number of removed lymph nodes was 4~10(mean,6.4).The drainage tube was taken out at 2~3 days after operation,with a drainage volume of 200~500 ml(mean,350 ml).One patient developed a temporary left recurrent laryngeal nerve palsy that disappeared at 3 months after operation.Follow-up checkups for 4~15 months(mean,8 months) in the 11 patients showed no recurrence or metastasis of tumor.Conclusions Video-assisted thoracoscopic surgery can be adopted in patients with esophageal carcinoma at stage Ⅰ or Ⅱ,

Objective To study the influence of CTP-OD1-HA and CTP-OD2-HA fusion peptides and combined with imatinib on proliferation of K562 cells.Methods K562 cells were treated with CTP-OD1-HA and CTP-OD2-HA peptides or together with imatinib.The proliferation of cells were detected and compared by MTT and clone formation methods.Results MTT examination demonstrated that CTP-OD1-HA and CTP-OD2-HA peptides could inhibit the proliferation of K562 cells,and the effect was more obvious when acted along with imatinib;Clone formation showed that CTP-OD1-HA and CTP-OD2-HA peptides suppressed the continuous colony forming ability of K562 cells.Conclusion CTP-OD1-HA and CTP-OD2-HA could specially inhibit the proliferation of K562 cells,and increase the sensitivity of imatinib.

Objective To discuss the effects of hospital-family transition period exercise management on respiratory function and exercise tolerance in elderly patients with chronic obstructive pulmonary disease (COPD)based on project management. Methods By convenient sampling method,a total of 89 elderly patients with COPD in stable stage were selected in Department of Respiration of Xinxiang Center Hospital from January 2017 to December 2018. According to the admission time,all subjects were divided into the intervention group(n=47)and control group(n=42). Patients in control group received standardized treatment and routine discharge guidance for COPD,while based on the intervention for control group,patients in the observation group developed exercise management model based on project management. The related indicators of respiratory function and exercise tolerance in the two groups were collected and compared on the day of discharge and 3 months after discharge at the outpatient visit. Results After intervention for 3 months,the levels of vital capacity(VC),forced vital capacity(FVC),forced expiratory volume in the first second(FEV1)and mean maximum expiratory flow(MMEF)in the control group were all higher than those on the day of discharge(t=6.228, 7.836,10.995,4.180;P<0.05),and the levels of VC,FVC,FEV1,peak expiratory flow(PEF),FEV1/FVC and MMEF were higher in the intervention group than those on the day of discharge(t=12.189,14.583,30.723, 6.352,6.166,12.420;P<0.05). After discharge for 3 months,the levels of VC,FVC,FEV1,PEF,FEV1/FVC and MMEF were higher in the intervention group than those in the control group(t=6.063,7.234,16.902, 5.596,2.640,7.295;P< 0.05). After discharge for 3 months,the 6-minute walking distance in two groups were both improved than those on the day of discharge(t=5.574,10.389;P<0.01),and the intervention group was better than control group(t=5.244,P< 0.01). Conclusions Hospital-family transition period exercise management based on project management can improve the respiratory function,and improve exercise tolerance in elderly patients with COPD,which helps patients recover early.