【Objective】 To investigate and analyze the status quo of confidential unit exclusion(CUE) in Xiamen from 2011 to 2020. 【Methods】 The data of all CUEs in Xiamen Blood Center from January 1, 2011 to December 31, 2020 were collected for statistical analysis. 【Results】 From 2011 to 2020, there were 511 602 blood donations in Xiamen, of which 64 were CUE (0.012%, 64/511 602); A total of 156 U blood was discarded, accounting for 0.17%(156/90 649) The main reason for CUE was " high risk behavior" (56.3%, 36/64); The main groups of CUE were male (70.3%, 45/64), 18~30 years old (60.9%, 39/64), college degree or above (53.1%, 34/64), and first-time blood donors (70.3%, 45/64). However, in terms of the proportion of blood donors, little significant difference in the rate of CUE was notable by age and gender (P>0.05), but by educational background and donation numbers (P<0.05). The anti-HIV positive rate of CUE was 1.56% (1 / 64) and significantly higher than that of non-CUE ( 0.14%, 725 / 511 538) (P<0.001). 【Conclusion】 CUE is one of the important measures to ensure blood safety. It is necessary to strengthen the consultation before blood donation and the popularization of blood safety knowledge after blood donation for specific groups, broaden the way to report after blood donation and improve the level of CUE.