Objective To observe the effect of Ganoderma lucidum and Astragalus membranaceus on the liver nucleic acid content of the mice exposed to the noise. Methods Noise-exposed mice were given Ganoderma lucidum and Astragalus membranaceus by stomach perfusion. Measured the liver nucleic acid content of the mice liver with diphenylamine and orcinol method. Results The DNA content of the liver cell nucleus, the RNA content of the liver cell nucleus and the RNA content of the liver cytoplasm in the experimental groups approached those in the normal group, but significantly higher than those in the noise exposed group (P

Objective To analyze the influencing factors of frailty in the patients with acute stroke,and to construct and verify its nomogram prediction model.Methods The simple random sampling method was a-dopted to select the inpatients with acute stroke admitted to a class 3A hospital of Suzhou City from Septem-ber 2022 to May 2023 as the study subjects.The general information questionnaires,Chinese version of Til-burg Frailty Scale(TFI),Health Questionnaire Depressive Symptom Group Scale(PHQ-9),Barthel Index(BI),Morse Fall Assessment Scale(MFS),Braden Pressure Ulcer Risk Assessment Scale and Kubota drink-ing water test were used to conduct the survey.The univariate and multivariate logistic regression were adopt-ed to analyze the influencing factors for frailty occurrence in the patients with acute stroke The nomogram prediction model was constructed.The Bootstrap method was adopted to conduct the internal verification of prediction model.The goodness of fit was evaluated by the Hosmer-Lemeshow test.The discrimination was e-valuated by the C-index.The consistency was verified by the calibration curve.Results A total of 193 patients with stroke were included,among them 70 cases developed frail with an incidence rate of 36.3％.The univari-ate analysis results showed that BMI,NIHSS score,PHQ-9 score,BI score,Braden score,age,history of diabe-tes,fall risk,modified Rankin scale(mRS)score ≥2 points and dysphagia were related with the frailty occur-rence in the patients with acute stroke(P＜0.05).The variables of the prediction model included the age,his-tory of diabetes,PHQ-9 score and Braden score.The area under the receiver operating characteristic(ROC)curve was 0.839(95％CI:0.781-0.897),the best cutoff value was 0.328,the sensitivity was 78.6％and the specificity was 75.6％.The Hosmer-Lemeshow test showed the goodness of fit was good(x2=12.281,P=0.139).C-index was 0.839(95％CI:0.781-0.897),the prediction mode had good discrimination.The cali-bration cure showed that the frailty occurrence risk predicted by the model had good consistency with the ac-tual risk occurrence.Conclusion The constructed nomogram model could predict the occurrence risk of frailty in the patients with acute stroke,which provides a basis for the nursing staff condcuting early screening and intervention.

With the increasing number of dementia patients by year, the research about the family caregivers is getting extensive. From the point of the stress reaction of family caregivers of dementia patients, we summarized different measure tools and their similarities and differences, so as to provide references for nursing staff in the research of dementia patients and their caregivers.

Objective:To investigate the application value of dual-source CT urography with stellar photon detectors in the diagnosis of gout.Methods:Forty patients who were diagnosed with gout according to American College of Rheumatology Guideline for the Diagnosis of Gout and received treatment between April 2018 and May 2020 were included in the observation group. Forty patients who were concurrently diagnosed with osteoarthritis and received treatment in the same hospital were included in the control group. All patients underwent dual-source CT urography with stellar photon detectors and corresponding biochemical index detection. Blood levels of uric acid, urea nitrogen, creatinine, total cholesterol, and triglyceride were compared between the observation and control groups.Results:Blood levels of uric acid, creatinine, urea nitrogen, total cholesterol, and triglyceride in the observation group were (519.38 ± 97.91) μmol/L, (110.21 ± 18.29) μmol/L, (12.21 ± 3.29) mmol/L, (6.49 ± 1.22) mmol/L, (3.45 ± 1.89) mmol/L, respectively, which were significantly higher than those in the control group (310.45 ± 61.40) μmol/L, (86.22 ± 13.12) μmol/L, (6.82 ± 1.75) mmol/L, (4.75 ± 0.56) mmol/L, (1.98 ± 0.85) mmol/L, respectively ( t = 11.43, 6.741, 9.148, 8.198, 4.486, all P < 0.05). Dual-source CT urography with stellar photon detectors revealed that urate crystals (color coded as green) were detected in 3 and 36 patients from the control and observation groups, respectively, with the detection rate of 7.5% (3/40) and 90% (36/40), respectively. There was significant difference in urate crystal detection rate between the observation and control groups ( χ2 = 24.993, P < 0.05). In the control group, no obvious destruction of bone, tendon and ligament were observed, urate deposition, total volume of (1.023 ± 0.83) cm 3, was found in feet and knee joint of a small number of patients. In the observation group, there were 30 patients with uric acid crystals and bone destruction in the metatarsophalangeal joint ( n = 6), distal tibia ( n = 7), distal fibula ( n = 3), proximal talus ( n = 4), proximal calcaneus ( n = 6), and wrist joint ( n = 4). There were 20 patients with ligament or tendon damage, involving deltoid ligament ( n = 2), Achilles tendon ( n = 10), and extensor and flexor tendon ( n = 53). Total volume of uric acid crystals was (32.22 ± 5.83) cm 3. The volume of uric acid crystals deposited in the hand, elbow, feet and knee was (8.00 ± 4.92) cm 3, (5.32 ± 2.75) cm 3, (36.00 ± 15.54) cm 3, and (13.31 ± 9.14) cm 3, respectively. Conclusion:Dual-source CT urography with stellar photon detectors has a high sensitivity in the diagnosis of gout, can accurately locate and quantify uric acid crystals and is of high application value in the diagnosis of gout.