Objective The aim of this study was to generate human cholesteryl ester transfer protein ( CETP) transgenic rabbits and analyze their biological properties.Methods We generated human CETP transgenic rabbits by DNA microinjection, and detected the expression of human CETP by real-time PCR and Western blot assay.The activity of CETP was measured using an activity assay kit.Results Human CETP transgenic rabbits were successfully generated by DNA microinjection.Compared with wide type rabbits, the expression of human CETP was dramatically increased in the liver of the human CETP transgenic rabbits.The plasma CETP activity was also much higher in the liver of human CETP transgenic rabbits than that of control rabbits.Conclusions The model of human CETP transgenic rabbits is successfully established by DNA microinjection.It will provide a useful tool for the studies of CETP biological function and its involvement in the mechanisms of cardiovascular diseases.

Objective To investigate the blood-borne occupational exposure situation of medical staffs and to analyze its risk factors in order to provide a basis for working out the protective measures of medical staffs and risk evaluation .Methods The monitoring data of medical staffs with blood-borne occupational exposure in our hospital from January 2013 to December 2015 were retrospectively analyzed for understanding the occupational exposure risk factors of medical staffs ,exposure sources ,preventive drugs , regular check-up and follow-up situation as well as the relationship between the occupational protection training and the occupational exposure occurrence rate .Results Females among occupational exposure persons were more than males during 2013-2015 ,nurses were more than doctors ,which were dominated by persons under 30 years old .The occupational exposure links were mainly pulling out needle ,followed by operation suture and medical wastes handling ;the occupational exposure mainly occurred at morning , followed by afternoon ,night was minimal .The occupational exposure occurrence rate after protection training was significantly lower than that before training ,the difference was statistically significant(P＜0 .01) .The exposure sources were in turn hepatitis B , syphilis ,AIDS and hepatitis C .No infection case occurred after 6-12 months regular check-ups and follow-up of serology and virology .Conclusion Conducting the occupational protection training for medical staffs ,strictly complying with the medical procedures and increasing the safety protective awareness can reduce the occurrence of occupational exposure and are conducive to control the occupational risk .

Objective:To explore the relationship between resilience and social function in patients with bipolar disorder.Methods:A total of 127 patients with bipolar disorder were investigated using the questionnaires of Connor-Davidson resilience scale (CD-RISC) and scale of social function of psychosis inpatients (SSFPI). The relationship between resilience and social function was analyzed by correlation analysis and stepwise multiple regression analysis.Results:The scores of resilience and social function of patients with bipolar disorder were (45.32±13.84) and (31.38±5.09) respectively.And the CD-RISC score of patients with bipolar disorder was positively correlated with the SSFPI total score ( r=0.499, P<0.01). The stepwise multiple regression analysis showed that the social function of patients with bipolar disorder was affected by tenacity( β=0.336, t=3.42, P=0.001), the age of first onset( β=0.186, t=2.416, P=0.017)and strength( β= 0.205, t=2.053, P=0.042), accounted for 29.9% of the total variation. Conclusion:The resilience level of patients with bipolar disorder is positively related with social function.Resilience levels can influence social function, so effective and targeted measures should be taken to improve their resilience level in order to improve social function of patients with bipolar disorder.