ObjectiveTo explore clinical application of selecting flap by using of digital technique in treatment of hemifacial atrophy.MethodsSeven patients with hemifacial atrophy were selected,preoperative CT angiography was performed,deformity and flap three-dimensional reconstruction and design bone and soft tissues using Mimics 14.3 software, latissimus muscular flap or femur anterolateral flap were selected,according to tilt donor area and recipient area blood vessel diameter. Defect model were printed using rapid prototyping. ResultsHemifacial atrophy had a good postoperative shape,and the flaps survived in all the 7 cases.Follow-up 3 years,the flaps look well and the patients get expecting results. ConclusionsThe digital technique was a relatively useful tool that can assist surgeons with reconstruction of the flap,and accurate marking of the extent of the flap to be harvested.Therefore avoiding intraoperative injuries to the blood vessels to better survival of the flaps.

Objective To provide applied anatomic data for relevant operations of blood vessels of perisacral promontory(BVPSP). Methods The composition of BVPSP including origin, course, diameter of the middle sacral vessels, the distance between the sacral promontory and the sacral 1 transverse trunk were observed on 37 adult cadavers. Result The BVPSP is composed of the common and internal iliac vessels, the superior segment of the middle sacral vessels and the sacral 1 transverse trunk. Middle sacral artery comes from abdominal aorta. Middle sacral veins are thin walled without valves. The average diameter of middle sacral artery and vein is 1.02 mm and 2.53 mm respectively. The distance between the sacral 1 transverse trunk and the sacral promontory is 5.75 mm. Conclusion The composition of BVPSP, especially middle sacral veins, plentiful vascular anastomosis are the anatomical basis leading to massive hemorrhage in the relevant operations.

Objective To determine the effect of heat and noise on erythrocyte memb rane ATPase activities in pilots during flying. Method Twenty- four pilots per forming bombing for 3h (45～53℃, 122～97dB in the cabin) served as the su bjects . 21 ground personnel served as control (27℃ in the room). Blood samples were t aken from both groups before flying (6:00 a.m), and immediately (12:00 a.m.) and 8h (8:00 p.m.) after flying. Na+-K+ATPase, and Ca2+-Mg2+ATPase activities in erythrocyte membran e were determined with colorimetry. Result The Na+-K+ATPase activity in eryth rocyte membrane at 6:00 a.m.in pilots was higher than that in control group at the s ame time (P<0.01). The Ca2+-Mg2+ATPase activities in erythrocyte membrane at 12:00 a .m. and 8:00 p.m. in pilots were significantly higher, compared with those in co ntrol group at the same time (P<0.01). Conclusion The ATPase values obtained in our study were all within normal range, and the daytim e variation of both groups are the same. Exposure of human body to heat and noi se for long time may be harmful, the higher ATPase activity is, the more catabol ism of ATP will be. ATP exhaustion will lead to Ca2+ overload in erythrocy te thus stiffen the red cell membrane.

Objective To build a method of mandible 3D model to measure and analysis, then to finish the operation simulation, providing anatomic data to avoiding the complicafious of mandible osteotomy. Methods Using CT data to reconstruct 3D model of mandible with blood vessel and bone, then using Simpleware to measure and analysis, and using Freeform system and an incision method of Boolean to simulation mandible osteotomy safely. Re, tits It was possible to use CT data to rebuild 3D model for 3D measure and analysis for operation simulation. The inferior alveolar artery and never were the main tiasues which went through the madibhilar. The length of mandibular foramen to anterior minus was (19.13±0.66) ram,and the ones to posterior ramus was (18.96± 0.64)mm. The angle of the mandible was (109.70±4.67)°. The rages of the remus for safe operation was (12.62±0.28)mm, and the safe rages about angle of the body and bottom of the mandible was (22.30±4.67)°. There were obvious differences from children to the aged in the mandible physiological and anatomic study. We can use Freeform system to simulate the operation on 3D model. Conclusion It is a new method to build 3D model and use Freefonn system to simulate operation and a new path to communion with patients for a good operation.

Objective To investigate the correlation between serum levels of brain natriuretic peptide (BNP), cancer antigen 125 (CA125) and interleukin-6 (IL-6) with the severity of acute myocardial infarction (AMI) and to evaluate their predictive value for major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI). Methods A total of 100 AMI patients who underwent PCI were enrolled in this study. Patients were divided into MACE group (n=36) and non-MACE group (n=64) based on the occurrence of MACE. Clinical data and serum levels of BNP, CA125 and IL-6 were compared between the two groups. The correlations of serum BNP, CA125 and IL-6 levels with the severity of AMI were analyzed. Factors influencing the occurrence of MACE after PCI in AMI patients were examined. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serum BNP, CA125 and IL-6 for MACE after PCI. Conventional predictive scheme combined risk factors served as the conventional prediction model, while a new prediction model was developed by incorporating serum BNP, CA125 and IL-6 into the conventional model. The area under the curve (AUC), net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were used to compare the predictive values of the two models. Results Among the 100 AMI patients, 36 experienced MACE within three months after PCI. The MACE group had significantly higher age, white blood cell (WBC) count, prevalence of prior myocardial infarction and severity of AMI compared to the non-MACE group (P < 0.05). Serum levels of BNP, CA125 and IL-6 were significantly higher in the MACE group than in the non-MACE group (P < 0.05). Serum BNP, CA125 and IL-6 levels were positively correlated with the severity of AMI (r=0.513, 0.406, 0.320; P < 0.05). Age, WBC count, history of myocardial infarction, and serum BNP, CA125 as well as IL-6 were identified as significant predictors for MACE after PCI (P < 0.05). The AUC for the combined prediction for MACE using BNP, CA125 and IL-6 was greater than that of each individual marker (Z=2.134, 2.005, 2.087; P < 0.05). When age, WBC count and history of myocardial infarction were combined as the conventional prediction model, and serum BNP, CA125 and IL-6 were added to form the new prediction model, the AUC of the new model was significantly higher than that of the conventional model (Z=2.321, P < 0.05). Compared with the conventional prediction scheme, the new prediction scheme had both NRI and IDI greater than zero P < 0.05). Conclusion Elevated serum levels of BNP, CA125 and IL-6 in AMI patients are associated with the severity of AMI and have predictive value for MACE after PCI. The new prediction model with BNP, CA125 and IL-6 demonstrates superior predictive performance for MACE after PCI compared to the conventional model.

Schistosomiasis is prevalent in 78 countries and territories worldwide, while the eastern and western parts of sub-Sahara Africa bear the highest disease burden due to schistosomiasis. Recently, climate change, international trade and travel, urbanization and war have increased the risk of cross-boundary importation and transmission of schistosomiasis, and schistosomiasis has increasingly become a public health concern in non-endemic countries and territories. Biomphalaria straminea, the intermediate host of Schistosoma mansoni, has colonized in southern China and its habitats continue to move northward. In addition, cross-boundary imported cases of schistosomiasis have been reported occasionally in China. However, the real number of cases may be underestimated greatly due to insufficient diagnostic capacity and weak awareness of case reporting for overseas imported schistosomiasis in healthcare facilities. It is necessary to establish a multi-party collaborative mechanism, improve corresponding systems and technical specifications, reinforce surveillance and early warning, and border management, enhance technical reserves and capability building, and improve the awareness of schistosomiasis prevention and healthcare-seeking among entry-exit personnel, in order to effectively address the threat of cross-boundary imported schistosomiasis.