1.Analysis on physical and psychological symptoms among the victims of the disaster in Nanba town of Sichuan Province
Chinese Journal of Disease Control & Prevention 2008;0(05):-
Objective Through investigation and analysis of physical and psychological symptoms among the victims of the disaster,to grasp physical and psychological condition of the victims of the disaster in establish place of Nanba town.Methods According to the mechanical random sampling method,11 of 21 pieces of tent community were randomly selected,then all people over 6 years of 1/6 families from each tent community were randomly selected,in total,486 people from 96 families were recruited as the sample of investigation and assessment.According to the designed questionnaire,face-to-face investigation was adopted.Results In 6 body symptoms,positive rate of cough was 1.85%,positive rate of angina was 0.82%,positive rate of tetter was 0.62%,positive rate of fever(≥38 ℃)and positive rate of diarrhea(≥3 times/day)were both 0.21%.No symtom of vomit was found.Among them,only 22.22% of the cough person seek medical advice in time.In 8 psychological symptom,positive rate of insomnia was 4.94%,positive rate of nervous discomfort was 2.88%,positive rate of palpitation was 2.06%,positive rate of discomfort in chest was 1.65%,positive rate of the headache was 1.44%,positive rate of shiver and numb was 0.41%,positive rate of sometimes unconfidence was 0.21%.No victim thinking life hopeless were found.Conclusions The victims of the disaster in Nanba town have good physical condition and psychological state in the recent week after the earthquake.It was attributed to implement of integrated prevention measures(including health and epidemic prevention).77.78% of the persons who had coughs has not sought medical advice in time.We should pay much attention on this facts.
2.Strategic thinking on hospital groups
Chinese Journal of Hospital Administration 1996;0(05):-
As a successful mode of hospital reform, the hospital group offers the key to the solution of some major problems hindering the development of hospitals. The objective of setting up a hospital group is to better realize the strategic goals of the hospitals. While hospital groups have different types and formation patterns, the key to success lies in the operating mechanism and management standards. Organizational and cultural building is of great significance to the long-term development of hospital groups.
3.Systematic Review of Efficacy of Tibolone Tablet in the Treatment of Senile Vaginitis
China Pharmacy 2016;27(30):4249-4251,4252
OBJECTIVE:To systematically review the clinical efficacy of Tibolone tablet in the treatment of senile vaginitis, and provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed,Medline,CJFD,CBM,VIP and Wangfang Database,randomized controlled trials(RCT)about Tibolone tablet in the treatment of senile vaginitis were collct-ed. Meta-analysis was performed by using Rev Man 5.2 software after data extract and quality evaluation. RESULTS:Totally 10 RCTs were enrolled,involving 909 patients. Results of Meta-analysis showed Tibolone tablet can significantly improve the cure rate of senile vaginitis [RR=1.46,95%CI(1.32,1.61),P<0.001],maturation vaginal cell index score [SMD=1.83,95%CI(1.65, 2.01),P<0.001] and vaginal health score [SMD=1.56,95%CI(1.21,1.92),P<0.001],reduce recurrence rate [RR=0.07,95%CI (0.02,0.18),P<0.001] and vaginitis score [SMD=-1.44,95%CI(-1.79,-1.08),P<0.001]. CONCLUSIONS:Tibolone tablet has good clinical efficacy in the treatment of senile vaginitis,it can improve the vaginal mucosa estrogen and vaginal environment, reduce recurrence rate.
4.The Investigation of Air Microorganisms Pollution in Underground Spaces
Shiying ZHENG ; Yongliang ZHANG ; Qiang ZHI
Journal of Environment and Health 1993;0(03):-
Objective To understand the air pollution by microorganisms in the underground spaces. Methods 51 underground spaces were investigated, the impact and sedimentation sampling methods were employed and the total bacterial count, mycetes, streptococcus and anaerobes in air were determined. ELESA was used to detect aflatoxin B1 in aspergillus flavus isolated from air. Results The total bacterial count in the air in underground spaces accorded with the military health standard. In the semi-closed spaces,the mycetes counts were 5 950 cfu/m3 and 9 500 cfu/m3 in aisle and rooms respectively, significantly higher than those in control group (P
5.Air Disinfection with Chlorine Dioxide in Saps
Yongliang ZHANG ; Shiying ZHENG ; Qiang ZHI
Journal of Environment and Health 1992;0(04):-
Objective To observe the effect of air disinfection with chlorine dioxide(ClO2)in the saps and determine the concentration change in order to ensure the safety for people to enter the saps.Methods The disinfection was done at the concentration of 1 000 mg/L and the spray dose of 10 ml/m3 and then to count the total bacteria and fungi with the cascade impactors in the saps before and after air disinfection and to monitor the concentration of ClO2 with the air ClO2 monitor(iTX).Results The 94.6% of the total bacteria and 92.1% of the fungi died in 30 minutes after disinfection.The concentration of ClO2 in the air decreased from 10 mg/m3 to 0.8 mg/m3 81 minutes later and to 0.3 mg/m3 96 minutes later,after 120 minutes,it was 0 mg/m3.Conclusion The air disinfection effect of ClO2 used at the dose of 10 ml/m3 and the concentration of 1 000 mg/L is satisfactory.96 minutes after disinfection,the concentration of ClO2 is safe for human health.
6.Clinical Observation on 67 Early Pregnancy Women Treated by Medicinal Abortion Combined with Fugong Decoction
Cuixia GAO ; Cuiying ZHANG ; Shiying YANG
Journal of Traditional Chinese Medicine 1992;0(08):-
Objective To observe the effect of Fugong Decoction(Decoction for Uterine Restroation) as assistant therapy of medicinal abortion for early pregnancy.Methods The 134 early pregnancy women who were volunteers of medicinal abortion were randomized into a treatment group and a control group with 67 cases in each.The control group was treated with Mifepristone and Misoprostol while the treatment group treated with Fugong Decoction based on these drugs.Totally they were treated for 7 days.The abortion effect,volume of vaginal bleeding,bleeding time,and time of urine human chorionic gonadotrophin(HCG) changed to negative were observed.Results In the treatment group,the time of discharge of gestational sac,volume of vaginal bleeding,bleeding time,time of urine HCG changed to negative,and abortion effect were all better than those of the control group,with significant difference(P
7.The effects of hypertonic-hyperoncotic solution on the lipopolysaccharide-stimulated ICAM-1 mRNA expression in human vascular endothelial cell
Shiying YUAN ; Xueping ZHANG ; Bangxiong ZENG
Chinese Journal of Anesthesiology 1994;0(05):-
Objective To investigate the alteration in intercellular adhesion molecule (ICAM)-l mRNA expression on the surface of human vascular endothelial cells (HUVECs) induced by LPS stimulation and the effects of hypertonic-hyperoncotic solution (HHS) . Methods HUVECs were enzymatically isolated and cultured in RPMI 1640 culture medium at 37℃ for about 7 days when a monolayer of endothelial cells has grown. The primarily cultured HUVECs were mixed with LPS 100ng/ml and incubated at 37℃ for 30min, 1,4,8, 12and 24 h. 10%NaCl and 10% hydroxyethyl starch (Fresenius) were added to RPMI 1640culture medium. The HHS concentrations were 0.25% and 0.5% respectively. HUVECs were first incubated with either HHS (0.25% , 0.5% ) or isotonic solution for 10 min, 1h and 4h and then stimulated by LPS for 4h. The ICAM-1 mRNA was measured by reverse transcriptase-PCR. Results There was slight expression of ICAM-1 mRNA on the surface of HUVECs in normal condition. ICAM-1 mRNA expression began to increase at 1h exposure to LPS and reached peak value at 4h. Both 0.25% and 0.5% HHS could prevent the LPS-induced ICAM-1 mRNA up-regulation (P
8.The effect of hypertonic-hyperoncotic solution on CD11b expression on the lipopolysaccharide-stimulated human neutrophils in vitro
Xueping ZHANG ; Shiying YUAN ; Yonggong REN
Chinese Journal of Anesthesiology 1995;0(10):-
Objective To investigate the effect of hypertonic-hyperoncotic solution (HHS) on CD11b expression on the surface of human neutrophils which are stimulated by lipopolysaccharide (LPS) in vitro. Methods Neutrophils were isolated from fresh peripheral venous blood of healthy volunteers aged 20-4oyr find incubated with LPS 100 ng/ml al 37℃ in 5% CO2 incubator for 15, 30, 60min, 4, 12 or 24h. HHS was prepared with 10%NaCl and 10% hydroxyethyl starch. Neutrophils were incubated with 0.25% or 0.5%HHS for 10min, 1h or 4h. Some of the HHS treated neutrophils were further subjected to LPS stimulation for 30 mm. CDllb on the surface of neutrophils were measured by using immunofluorescence and flow cytometry. Results CD11b expression on neutrophils increased significantly after being exposed to LPS for 15min (P
9.Clinical Analysis of 116 Cases of Keloids Treated by Combination of Surgical Resection and Immediate Postoperative Electron Beam Radiotherapy
Mengxian ZHANG ; Na HAN ; Shiying YU
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2009;38(5):683-685
Objective To evaluate the role of postoperative electron beam radiotherapy in the management of ke-loids. Methods Between January 2004 and December 2006,116 cases of keloids were treated with 6 MeV electron beam radiotherapy within 24 h after surgical resection of the keloids. All patients had received a total of 21 Gy in seven daily 3-Gy fractions. Treatment was started at the 24th h after surgery. Patients were followed up and the information regarding treatment results, early and late radiation toxicity,and the satisfaction level by self-assessments was recorded. Results Recurrence occurred in 17 cases of keloids(14. 7%),and was correlated with site of the lesions(χ~2 =29. 91,P<0. 01). Most recurrences were observed at site of sternum (10/43) and shoulder (5/13 ). Keloid associated symptoms, e. g. itching and pain, were improved in 88. %%. For early toxicity outcomes, 100% had grade 1~2 skin erythema,7. 8% had wound delayed union,and 4. 3% had infection. For late toxicity outcomes, 30. 2% reported grade 1~2 hyperpigmentation, 11. 2% grade 1~2 hypopigmentation, and 5. 2% grade 1 telangiectasia. No severe complications or secondary malignancies were observed. 72. 4% patients described the results of treatment as excellent or good,and 15. 5% patients were not satisfied with the treatment results. Conclusion Postoperative electron radiotherapy is well tolerated and effective in preventing keloid recurrence.
10.Tanshinone type IIA inhibits osteoprotegerin and osteoclast differentiation factor expression at relapse stage after orthodontic tooth movement
Shiying ZHANG ; Jiguang LIU ; Gang ZHAO
Chinese Journal of Tissue Engineering Research 2014;(11):1730-1736
BACKGROUND:In recent years, many drugs emerge to control tooth movement, and scholars in China begin to investigate Chinese herbs with moderate nature and smal adverse reaction.
OBJECTIVE:To observe the relapse after orthodontic tooth movement, osteoprotegerin and osteoclast differentiation factor expression in periodontal tissue after rats were treated with local tanshinone type IIA at different doses.
METHODS:A total of 48 male Wistar rats were randomly divided into four groups:control, low dose (tanshinone type IIA 0.36 mg/d), medium dose (tanshinone type IIA 0.72 mg/d), and high dose (tanshinone type IIA 1.44 mg/d) groups. Taking anterior teeth as the anchorage, the maxil ary first molar of rats was tracted to mesial movement. In experimental groups, gingival mucosa of the first molar was local injected with tanshinone type IIA 1 day
before the force device was removed, while control group was injected with physiological saline, once a day, for 4 weeks. Immediately, 1 week, and 4 weeks after the force device was removed, the distance between the maxil ary first molar and second molar was measured and body mass was weighted. The animals were kil ed after 4 weeks, osteoprotegerin and osteoclast differentiation factor expression in maxil ary first molar and periodontal tissue were determined using immunohistochemical staining.
RESULTS AND CONCLUSION:There was no obvious change in the body weight of rats in each group (P>0.05). In low, medium and high dose groups, recurrent distance of the teeth was shorter than that in control group (P<0.05), and recurrence percentage was significantly lower than control group (P<0.05). The greater the dose was, the
smal er the degree of recurrence was. Osteoprotegerin expression in the periodontal tissue was significantly higher in the experimental groups than the control group (P<0.05), while osteoclast differentiation factor expression was significantly lower than the control group (P<0.05). The ratio of osteoprotegerin/osteoclast differentiation factor in the periodontal tissue was greater than 1 in both control group and experimental groups, and reached the peak in the high dose group. Local delivery of tanshinone type IIA has no impact on body weight of normal rats, and can effectively control the recurrence rate after orthodontic tooth movement. Within a certain range, high dose achieves the most obvious effect. Regulating osteoclast through adjusting the ratio of osteoprotegerin/osteoclast differentiation factor could be the molecular mechanism of tanshinone type IIA accelerating the periodontal tissue rebuilding.