Lactate is considered a dead-end product of glycolysis.Its generation and accumulation promotes tumor growth and metastasis,and it is related to the poor prognosis of tumor.But recent studies have found,tumor cells can also uptake and utilize lactate.With the recent advances in tumor metabolism and gene therapy,lactate is a potential therapeutic target in tumors.

Tooth eruption is a series of complicated physiological processes occurring once the crown is formed completely, as well as when the tooth moves toward the occasion plane. As such, the tooth moves through the alveolar bone and the oral mucosa until it finally reaches its functional position. Most studies indicate that the process of tooth eruption involves the alveolar bone, dental follicles, osteoclasts, osteoblasts, and multiple cytokines. Dental follicles regulate both resorption and formation of the alveolar bone, which is required for tooth eruption. Furthermore, root formation with periodontal ligament facilitates continuous tooth eruption. However, the exact mechanism underlying tooth eruption remains unclear. Hence, this review describes the recent research progress on the cellular and molecular mechanisms of tooth eruption.
Dental Sac ; Humans ; Osteoblasts ; Osteoclasts ; Periodontal Ligament ; Tooth ; Tooth Eruption ; physiology ; Tooth Root

Objective To analyze the monitoring results of severe fever with thrombocytopenia syndrome (SFTS) in Shiyan, Hubei province, and to provide a scientific basis for the prevention and control of SFTS. Methods Descriptive epidemiological analysis was conducted on the surveillance data of SFTS, and real-time PCR was performed for detecting SFTSV RNA. Results A total of 54 laboratory-confirmed cases of SFTS were reported in Shiyan from 2011 to 2022, including 5 deaths (9.26%). The cases mainly occurred in March to October, with a peak in April to August (85.18%). People over 50 years old were the high-risk group (94.44%), and farmers were the high-risk occupation (92.59%). The male to female sex ratio was 0.64:1. The three northern counties (Danjiangkou City, Yunyang District, and Yunxi County) were high-incidence areas (90.74%). There was no statistical difference in the positive rates of sampling between within 7 days and 8-11 days after onset (66.67% vs. 57.14%) (Fisher's precision probability test , P＝0.674 ). Conclusion The incidence of SFTS in Shiyan is mainly sporadic, dominated by middle-aged and elderly people and farmers, and shows obvious seasonal and regional characteristics . It is necessary to strengthen vector management, health education, SFTS case reporting and sample collection, and inspection management of high-risk groups, and increase prevention and control efforts in the three northern counties of Shiyan.

Humans ; Melanoma ; Metaplasia ; Mucous Membrane ; Nasopharynx

usions DCUS could initial estimate the pathological typing of advanced gastric caner before operation.

Objective To investigate the clinical value of double contrast-enhanced ultrasonography (DCUS)in diagnosing Lauren classification of advanced gastric carcinoma.Methods Fifty-eight patients with gastric cancer proved by endoscopic biopsy underwent preoperative DCUS examination,and the findings were compared with postoperative pathologic results via hematoxylin-eosin and alcian blue-periodic acid schiff(AB-PAS)staining.Results In 58 patients,34 cases were diagnosed as intestinal type and 24 cases as diffuse type by pathology after operation.In intestinal type,30 cases were enhanced as global homogeneous intensity by using DCUS.another 2 cases as"lamellar"model and the other 2 cases as heterogeneous intensity.However,in diffuse type,22 cases were enhanced heterogeneously with"barrier"signs in 5 cases,"map"signs in 9 cases and"lamellar"signs in 8 cases.the remaining 2 cases of diffuse type enhanced as homogeneous model.The sensitivity and specificity of heterogeneous enhancement in diagnosing diffuse type of advanced gastric cancer was 91.7%and 88.2%respectively,and the Youden's index was 0.8.Conclusions DCUS could be considered as a new valuable method to distinguish the Lauren classification and evaluate the invasiveness,metastasis and prognosis in patients with gastric carcinoma.

Objective To investigate the clinical value of double contrast-enhanced ultrasonography (DCUS)in Borrmann classification of advanced gastric carcinoma preoperatively. Methods A total of 69 patients with advanced gastric carcinoma were examined by ultrasound after taking oral contrast agent and bolus injection of SonoVue preoperatively.A comparison with final pathologic results was made after surgery. Results The accuracy of oral contrast-enhanced ultrasonography and DCUS in Borrmann classification of advanced gastric cancer were 78.3%and 91.3%,respectively.There was a significant difference between two methods(X2=4.087,P＜0.05).In addition,Kappa value of two methods were 0.73 and 0.90,respectively.Conclusions DCUS is a new valuable method for Borrmann classification with its high accuracy preoperatively.

Objective To investigate the value of oral and intravenous contrast enhanced ultrasonography-double contrast ultrasonography (DCUS) in the evaluation of differentiation degree of gastric cancer. Methods Fifty-three patients who had been diagnosed as gastric cancer by gastroscope and confirmed by pathology after operation were examined by DCUS, and they were divided into moderately to well differentiated group and poorly differentiated group. The correlation of size and enhancement features of the lesions was compared with differentiation degree of gastric cancer. Results The size and enhancement distribution of lesions were markedly correlated with the degree of differentiation. The baseline intensity(BI)in poorly differentiated group was lower than that in well and moderately differentiated group[(0.52±1.12)dB vs (1.53±1.87) dB, P<0.05], but enhanced intensity(EI) was higher than that in the second group [(26.22±3.69)dB vs (23.69±5.02)dB, P<0.05]. Conclusions DCUS could initial evaluate the degree of differentiation of gastric cancer before operation.

Humans ; Nasal Cavity ; Melanoma ; Skin Neoplasms ; Paranasal Sinuses

Objective To analyze the factors affecting the effects of hearing aids in presbycusis patients . Methods One hundred and twenty cases with presbycusis were investigated by using general data and the Satisfac-tion with Amplification in Daily Life questionnaire(SADL) .The individual scores and total scores of all the subjects were collected together with the personal information ,including age ,gender ,degree of education ,pure-tone aver-age ,hearing aid type ,monaural/binaural status ,total hearing aid experience ,daily use time ,the time of perceived hearing difficulty .A single factor analysis and multiple stepwise regression analysis were used to filter out main fac-tors influencing the effect of hearing aids .Results The degree of education ,hearing aid type ,monaural/binaural status ,daily use time ,the time of perceived hearing difficulty were factors influencing the effect of hearing aids . The patients with higher level of education ,the longer daily use ,binaural status obtained more scores than those of the low degree of education ,the shorter daily use ,and monaural status( P< 0 .01) .The older people felt better than the youngers(P<0 .01) .The patients with long -time perceived hearing difficulty got more scores than those with short -time perceived hearing difficulty (P<0 .01) .In general ,the degree of education ,and the daily use time were the main factors influencing the effects of hearing aids .Conclusion There are many factors that influence the effects of hearing aids ,in which the degree of education ,daily use time are the main factors ,and the combination of the two factors obtain the effects of hearing aid maximization ,and the binaural status ,the short time of perceived hearing difficulty and the older obtain better satisfaction .The gender doesn't significantly influence the effects of the hearing aids .