Objective? To investigate the correlation between nursing humanistic care and health behavior ability in elder patients with diabetes mellitus (DM). Methods? From June 2015 to June 2017, a total of 208 elder patients with DM in Affiliated Hospital of Yangzhou University were selected by convenience sampling method. The levels of nursing humanistic care and health behavior ability were evaluated by Nursing Humanistic Care Experience Scale-Noninfectious Chronic Disease Patients Version (NHCES-NCDP) and Self-Rated Abilities for Health Practices Scale (SRAHP). Results? The average score of NHCES-NCDP was (68.64±7.27), and the lowest dimension score was support for individual uniqueness (2.60±0.30). The SRAHP average score was (55.40±4.80), the lowest dimension score was nutrition (12.25±2.00). Pearson correlation analysis showed that the total score and dimension scores of NHCES-NCDP were positively correlated with total score and the dimension scores of SRAHP (P＜ 0.05). Multivariate linear regression showed that the level of nursing humanistic care were the influencing factor for health behavior ability (P＜0.01). Conclusions? The levels of nursing humanistic care and health behavior ability in elder patients with DM is low. Improving the level of nursing humanistic care can improve the patient's health behavior ability.

Objective:To evaluate the one year therapeutic effect of respiratory rehabilitation in patients with chronic ob-structive pulmonary disease(COPD)and identify prognostic risk factors. Method:COPD patients,hospitalized in the First Affiliated Hospital of Guangzhou Medical University from January 2017 to March 2019,were retrospectively analyzed.A total of 418 target patients,enrolled by 1∶1 propensity score matching,were divided into respiratory rehabilitation group and conventional treatment group according to whether they had received respiratory rehabilitation therapy.Among them,209 cases in respirato-ry rehabilitation group and 209 cases in conventional treatment group were compared one year after discharge.According to the occurrence of adverse prognostic events(death or aggravated hospitalization),the patients were divided into favorable prognosis group and bad prognosis group.According to the survival time＞1 year and＜1 year,the patients were divided into survival group and death group.x2 test was used for univariate analysis,and multivariate logistic regression model and multivariate cox proportional hazards regression model were used for multivariate analysis. Result:One year after discharge,respiratory rehabilitation group had fewer exacerbation hospitalizations than conventional treatment group(0.89±1.21 vs.1.23±1.18,P=0.008),fewer annual exacerbation hospitalizations(43.5％vs.61.7％,P＜0.001)and fewer annual frequent exacerbation hospitalizations(16.7％vs.28.2％,P=0.006),but no significant difference in the annual mortality between two groups(15.3％vs 13.4％,P＞0.05).There were significant differences between the poor prognosis group and the favorable prognosis group in respi-ratory rehabilitation therapy,history of aggravated hospitalization in the previous year,arterial blood carbon di-oxide level and bicarbonate level(P＜0.05).Arterial blood carbon dioxide level and venous blood hemoglobin level in the death group were significantly different from those in the survival group(P＜0.05).Multivariate lo-gistic regression analysis showed that the history of exacerbation hospitalization,no respiratory rehabilitation in the previous year,anemia and hypercapnia were independent risk factors for poor prognosis one year after dis-charge(P＜0.05).Multivariate cox proportional hazards regression analysis showed that anemia and hypercapnia were independent risk factors for mortality one year after discharge(P＜0.05). Conclusion:Respiratory rehabilitation therapy extended from early hospitalization to discharge effectively re-duced the composite risk of death or re-exacerbation of hospitalization in COPD patients one year after dis-charge,which is worthy of promotion.Anemia and hypercapnia were risk factors for death one year after dis-charge,and history of previous exacerbation hospitalization was a risk factor for death or re-exacerbation hospi-talization after one year discharge.

OBJECTIVE: To investigate the effects of fecal microbiota transplantation (FMT) on intestinal microbiome and organism in patients with severe pneumonia during the convalescence period. METHODS: A prospective non-randomized controlled study was conducted. From December 2021 to May 2022, patients with severe pneumonia during the convalescence period who received FMT (FMT group) and patients with severe pneumonia during the convalescence period who did not receive FMT (non-FMT group) admitted to the First Affiliated Hospital of Guangzhou Medical University were enrolled. The differences of clinical indicators, gastrointestinal function and fecal traits between the two groups were compared 1 day before and 10 days after enrollment. The 16S rDNA gene sequencing technology was used to analyze the changes of intestinal flora diversity and different species in patients with FMT before and after enrollment, and metabolic pathways were analyzed and predicted by Kyoto Encyclopedia of Genes and Genomes database (KEGG). Pearson correlation method was used to analyze the correlation between intestinal flora and clinical indicators in FMT group. RESULTS: The level of triacylglycerol (TG) in FMT group was significantly decreased at 10 days after enrollment compared with before enrollment [mmol/L: 0.94 (0.71, 1.40) vs. 1.47 (0.78, 1.86), P < 0.05]. The level of high-density lipoprotein cholesterol (HDL-C) in non-FMT group was significantly decreased at 10 days after enrollment compared with before enrollment (mmol/L: 0.68±0.27 vs. 0.80±0.31, P < 0.05). There were no significant differences in other clinical indexes, gastrointestinal function or fecal character scores between the two groups. Diversity analysis showed that the α diversity indexes of intestinal flora in FMT group at 10 days after enrollment were significantly higher than those in non-FMT group, and β diversity was also significantly different from that in non-FMT group. Differential species analysis showed that the relative abundance of Proteobacteria at the level of intestinal flora in FMT group at 10 days after enrollment was significantly lower than that in non-FMT group [8.554% (5.977%, 12.159%) vs. 19.285% (8.054%, 33.207%), P < 0.05], while the relative abundance of Fusobacteria was significantly higher than that in non-FMT group [6.801% (1.373%, 20.586%) vs. 0.003% (0%, 9.324%), P < 0.05], and the relative abundance of Butyricimonas, Fusobacterium and Bifidobacterium at the genus level of the intestinal flora was significantly higher than that in non-FMT group [Butyricimonas: 1.634% (0.813%, 2.387%) vs. 0% (0%, 0.061%), Fusobacterium: 6.801% (1.373%, 20.586%) vs. 0.002% (0%, 9.324%), Bifidobacterium: 0.037% (0%, 0.153%) vs. 0% (0%, 0%), all P < 0.05]. KEGG metabolic pathway analysis showed that the intestinal flora of FMT group was changed in bisphenol degradation, mineral absorption, phosphonate and phosphinate metabolism, cardiac muscle contraction, Parkinson disease and other metabolic pathways and diseases. Correlation analysis showed that Actinobacteria and prealbumin (PA) in intestinal flora of FMT group were significantly positively correlated (r = 0.53, P = 0.043), Bacteroidetes was positively correlated with blood urea nitrogen (BUN; r = 0.56, P = 0.029) and complement C3 (r = 0.57, P = 0.027), Firmicutes was positively correlated with BUN (r = 0.56, P = 0.029) and complement C3 (r = 0.57, P = 0.027), Fusobacteria was significantly positively correlated with immunoglobulin M (IgM; r = 0.71, P = 0.003), Proteobacteria was significantly positively correlated with procalcitonin (PCT; r = 0.63, P = 0.012) and complement C4 (r = 0.56, P = 0.030). CONCLUSIONS FMT can reduce TG level, reconstruct intestinal microecological structure, change body metabolism and function, and alleviate inflammatory response by reducing the relative abundance of harmful bacteria in patients with severe pneumonia during the convalescence period.
Humans ; Fecal Microbiota Transplantation ; Complement C3 ; Convalescence ; Prospective Studies ; Feces