1.Non-union of fractures in Riley Day Syndrome
Brunei International Medical Journal 2012;8(1):48-51
Riley Day Syndrome, also known as familial dysautonomia, is a rare reported entity characterised by disturbance of pain and temperature perceptions, inability to produce tears, labile blood pressure and poor growth due to disorder of the autonomic and sensory nervous system. It is an autosomal recessive condition with the genetic locus mapped to chromosome 9q31-q33. Traumatic fractures are common and due to lack of pain, may go unrecognised for prolonged periods of time, resulting in nonunion or pseudoarthrosis. Scoliosis is seen in up to 90% of the patients. Complications of are common in these patients and range from infection to wound breakdown to failure of fixation. We report a case (nineyear-old girl) of Riley Day Syndrome with general absence of pain and damage to the extremities to highlight this rare syndrome
Pseudoarthrosis
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Dysautonomia, Familial
2.Hand Injuries in the Oil Fields of Brunei Darussalam
Malaysian Orthopaedic Journal 2013;7(1):49-51
Hands are essential organs and their agility and dexterity are vital to our daily lives. In the present study, we analysed 107 patients who presented at the local hospital with hand injuries sustained in the oil fields, oil industries and related employment sectors from the surrounding regions. All the patients were male and the mean age was 37.89 years (range,21-61y). Forty-seven (43.93%) patients had simple cut injuries, 14 patients (13.08%) had tendon injuries, 13 patients (12.14%) had amputation of the digit (30.84%) had
bone fractures (including 20 (66.66%) open fractures). Only
19 (17.75%) patients were admitted in hospital for further
treatment. Ninety-one (85.04%) patients injured within one
year of employment and 57(53.27%) patients were not
satisfied with instructions and orientation before starting
their job. Hand injury is one of the most common injuries in the oil industry and overtime work further increases
incidence of this injury.
3.The Predictors of Parent Reported Behaviors Related to Olfactory Information Processing in Children with ADHD.
Psychiatry Investigation 2010;7(2):116-121
OBJECTIVE: Attention deficit hyperactivity disorder (ADHD) is a heterogeneous disorder with contradictory findings about smell detection function. It is not clear if the parent perceived behavior related to olfactory function is associated with age, gender, severity of ADHD, and cooccurring symptoms of anxiety and oppositional behavior in children with ADHD. METHODS: Participants were a clinical sample of 104 children and adolescents with ADHD using DSM-IV diagnostic criteria by a semi-structured interview. Parent perceived behavior related to olfactory processing function was assessed trough a questionnaire. The parent reported Olfactory Functioning Checklist was used to evaluate "seeking behavior and over-responsiveness to smell (SSBO)" and "smell detection ability (SDA)". RESULTS: ADHD and separation anxiety symptoms count (severity) predicted the SDA scale score. None of the variables of gender, age, ADHD subtypes, co-morbidity with oppositional defiant disorder (ODD), and symptom count of ODD predicted SSBO and SDA scales' scores. CONCLUSION: Parent reported behavior related to olfactory detection impairment increased with higher ADHD and anxiety severity. It is independent of age and gender.
Adolescent
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Anxiety
;
Anxiety, Separation
;
Attention Deficit and Disruptive Behavior Disorders
;
Attention Deficit Disorder with Hyperactivity
;
Automatic Data Processing
;
Checklist
;
Child
;
Diagnostic and Statistical Manual of Mental Disorders
;
Humans
;
Parents
;
Surveys and Questionnaires
;
Smell
4.Longevity of Toxocara cati Larvae and Pathology in Tissues of Experimentally Infected Chickens.
Ahmad ORYAN ; Seyyed Mahmoud SADJJADI ; Shahrzad AZIZI
The Korean Journal of Parasitology 2010;48(1):79-80
This study was conducted to determine the distribution patterns and duration of stay of Toxocara cati larvae in organs of chickens and to investigate chronic phase and potential zoonotic risk of toxocariasis in chickens. Chickens were orally infected with 1,000 embryonated T. cati eggs and necropsied 240 days post-infection. Organs of the chickens were examined at gross and microscopic levels; tissues were digested to recover larvae. Peribronchiolitis with infiltration of lymphocytes, and hyperplasia of bronchiolar associated lymphatic tissues (BALT) and goblet cells, were evident in the lungs of infected chickens. There were mild hemorrhages and infiltration of lymphocytes and a few eosinophils in the meninges. Larvae were recovered from 30% of the exposed chickens. Larvae recovery indicated that T. cati larvae stay alive for at least 240 days in the chicken brain. Therefore, chickens may potentially act as a paratenic host in nature and transfer T. cati larvae to other hosts.
Animals
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Brain/pathology
;
Chickens
;
Larva/physiology
;
*Longevity
;
Lung/pathology
;
Poultry Diseases/*parasitology/*pathology
;
Toxascariasis/pathology/*veterinary
;
Toxocara/*pathogenicity/*physiology
5.Sensory Processing Problems in Children with ADHD, a Systematic Review.
Psychiatry Investigation 2011;8(2):89-94
One of the most common psychiatric disorders in children is attention deficit hyperactivity disorder (ADHD). Its course and outcome are heterogeneous. Sensory processing problems impact the nature of response to daily events. ADHD and sensory problems may occur together and interact. No published review article about sensory processing problems in children with ADHD were found. A systematic search, conducted on Pub-Med (up to January 2010), and Google Scholar, yielded 255 abstracts on sensory processing problems in children including 11 studies about sensory problems in children with ADHD. Sensory processing problems in children with ADHD is not a well studied area. Sensory processing problems in children with ADHD are more common than in typically developing children. Findings do not support that ADHD subtypes are distinct disorders with regard to sensory processing problems. However, co-morbidity with oppositional defiant disorder and anxiety are predictors of more severe sensory processing problems in children with ADHD.
Anxiety
;
Attention Deficit and Disruptive Behavior Disorders
;
Attention Deficit Disorder with Hyperactivity
;
Child
;
Humans
6.Hematological and Serum Biochemical Analyses in Experimental Caprine Besnoitiosis.
Saeed NAZIFI ; Ahmad ORYAN ; Fatemeh NAMAZI
The Korean Journal of Parasitology 2011;49(2):133-138
This study was undertaken to investigate the hematological and biochemical changes in experimentally infected goats with Besnoitia caprae from the time of infection till 360 days post-infection (PI). Six male goats were inoculated subcutaneously with 13x10(7) bradyzoites of B. caprae, and blood samples were collected from the jugular vein. The total erythrocyte and total leukocyte counts, hematocrit value, and differential leukocyte counts were determined. Serum biochemical analysis, including the total protein, albumin, total globulin, cholesterol, triglyceride, chloride, testosterone, calcium (Ca2+), inorganic phosphorus, sodium (Na+), potassium (K+), iron (Fe2+), glucose, serum amyloid A (SAA), haptoglobin (Hp), fibrinogen, ceruloplasmin, aspartate aminotransferase, alanine aminotransferase, creatine kinase, lactate dehydrogenase, and alkaline phosphatase, was undertaken. Skin biopsy from the limbs were collected at weekly intervals and histologically examined for Besnoitia cysts. Cysts were present in the skin biopsies of the leg of the infected goats from day 28 PI. There were variations in hematological analyses, but no significant difference was seen. From day 30 to 360 PI, results showed that SAA, Hp, fibrinogen, and ceruloplasmin concentrations increased, whereas testosterone concentrations decreased. Infected goats exhibited decrease of albumin and increase of serum total protein and globulin concentrations. By contrast, there were no significant differences in the remained analyses concentrations.
Animals
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Biopsy
;
Blood Chemical Analysis
;
Coccidiosis/*parasitology/*pathology
;
Disease Models, Animal
;
Erythrocyte Count
;
Goat Diseases/*parasitology/*pathology
;
Goats
;
Hematocrit
;
Histocytochemistry
;
Leukocyte Count
;
Male
;
Sarcocystidae/*isolation & purification/*pathogenicity
;
Skin/pathology
;
Time Factors
7.Ancient Schwannoma of the cervical sympathetic chain: A case report.
Primuharsa Putra Sabir Husin Athar ; Norleza Ahmad Norhan * ; Megat Shiraz Megat Abdul Rahman
Malaysian Journal of Medical Sciences 2007;14(1):75-78
Schwannoma of the cervical sympathetic chain is an extremely rare nerve tumour. We report an unusual swelling in a 41-year-old female who presented with an asymptomatic solitary mass in the right parapharyngeal space. Clinical examination and computed tomography showed displaced carotid artery in an antero-medial direction. Surgical excision of the lesion was carried out and histological examination revealed an Ancient Schwannoma.
Neurilemmoma
;
Case Report
;
Absence of symptoms
;
Lesion, NOS
;
X-Ray Computed Tomography
8.Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype.
Nargess ARANDI ; Mani RAMZI ; Fatemeh SAFAEI ; Ahmad MONABATI
Blood Research 2018;53(4):294-298
BACKGROUND: Production of immunosuppressive enzymes such as indoleamine 2,3-dioxygenase (IDO) is one of the strategies employed by hematologic malignancies, including acute myeloid leukemia (AML), to circumvent immune surveillance. Moreover, IDO has the ability to convert CD4+CD25− conventional T cells into regulatory T cells (Tregs). In this study, we evaluated the expression of IDO in cytogenetically normal acute myeloid leukemia (CN-AML) patients and its correlation with the Treg marker, FOXP3, as well as clinical and laboratory parameters. METHODS: Thirty-seven newly diagnosed CN-AML patients were enrolled in our study along with 22 healthy individuals. The expression of the IDO and FOXP3 genes was analyzed by SYBR Green real-time PCR. RESULTS: Both IDO and FOXP3 were highly upregulated in CN-AML patients compared to control groups (P=0.004 and P=0.031, respectively). A positive correlation was observed between IDO and FOXP3 expression among AML patients (r=0.512, P=0.001). Expression of IDO and FOXP3 showed no significant correlation with laboratory parameters such as white blood cell and platelet counts, hemoglobin levels, bone marrow blast percentage, gender, and FLT3 mutation status (P>0.05). CONCLUSION: Higher IDO expression in CN-AML patients may be associated with an increased Treg phenotype which may promote disease progression and lead to poor prognosis of CN-AML patients.
Bone Marrow
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Disease Progression
;
Hematologic Neoplasms
;
Humans
;
Indoleamine-Pyrrole 2,3,-Dioxygenase*
;
Karyotype*
;
Leukemia, Myeloid, Acute*
;
Leukocytes
;
Phenotype*
;
Platelet Count
;
Prognosis
;
Real-Time Polymerase Chain Reaction
;
T-Lymphocytes
;
T-Lymphocytes, Regulatory
9.Relationship between religion and school students' road behavior in southern Iran.
Reza TABRIZI ; Maryam AKBARI ; Kamran B LANKARANI ; Seyed Taghi HEYDARI ; Alireza MASOUDI ; Amir Hossein SHAMS ; Armin AKBARZADEH ; Saba MOALEMI ; Maryam Mahmoodi MEHR ; Ahmad Kalateh SADATI ; Payam PEYMANI
Chinese Journal of Traumatology 2017;20(5):264-269
PURPOSEUnsafe behaviors are an important cause of accidents in adolescent age groups. This study was designed to examine the behaviors of adolescent pedestrians in southern Iran.
METHODSThis is a descriptive analytical cross-sectional study. The study population consisted of high school students in Shiraz, capital city of Fars Province, Iran. Five hundred and sixteen students were selected by multi-stage sampling. Data were collected by the use of three questionnaires, which included Persian copies of adolescent road user behavior questionnaire (ARBQ), Duke University Religious Index (DUREL), as well as the context and independent variables questionnaire.
RESULTSThe results showed that a decrease in dangerous behaviors on the road resulted in an increase in respondents' intrinsic religiosity. Also, engagement in unsafe crossing behavior in the road decreased with increasing respondents' intrinsic religiosity. Another finding showed that female students were less involved in dangerous play and planned protective behaviors on the road.
CONCLUSIONFindings clearly indicate that intrinsic religiosity has a significant role in reducing the risky road behaviors of students. Hence, religion may improve road safety in school students' road behavior in Iran.
10.Antimicrobial and cytotoxic activity of Ferula gummosa plant essential oil compared to NaOCl and CHX: a preliminary in vitro study.
Abbas ABBASZADEGAN ; Ahmad GHOLAMI ; Hosein MIRHADI ; Mina SALIMINASAB ; Aboozar KAZEMI ; Mahmood Reza MOEIN
Restorative Dentistry & Endodontics 2015;40(1):50-57
OBJECTIVES: The usage of medicinal plants as natural antimicrobial agents has grown in many fields including dental medicine. The aim of this in vitro study was three-fold: (i) to determine the chemical compositions of the Ferula gummosa essential oil (FGEO), (ii) to compare the antimicrobial efficacy of the oil with sodium hypochlorite (NaOCl) and chlorhexidine (CHX), (iii) to assess the toxic behavior of FGEO in different concentrations compared to 5% NaOCl and 0.2% CHX. MATERIALS AND METHODS: Gas chromatography/mass spectrometry (GC/MS) was used to determine the chemical compositions of the oil. The disk diffusion method and a broth micro-dilution susceptibility assay were exploited to assess the antimicrobial efficacy against Enterococcus faecalis, Staphylococcus aureus, Streptococcus mitis, and Candida albicans. The cytocompatibility of the FGEO was assessed on L929 fibroblasts, and compared to that of NaOCl and CHX. RESULTS: Twenty-seven constituents were recognized in FGEO. The major component of the oil was beta-pinene (51.83%). All three irrigants significantly inhibited the growth of all examined microorganisms compared to the negative control group. FGEO at 50 microg/mL was effective in lower concentration against Enterococcus faecalis than 5% NaOCl and 0.2% CHX, and was also more potent than 0.2% CHX against Candida albicans and Staphylococcus aureus. FGEO was a cytocompatible solution, and had significantly lower toxicity compared to 5% NaOCl and 0.2% CHX. CONCLUSIONS: FGEO showed a promising biological potency as a root canal disinfectant. More investigations are required on the effectiveness of this oil on intracanal bacterial biofilms.
Anti-Infective Agents
;
Biofilms
;
Candida albicans
;
Chlorhexidine
;
Dental Pulp Cavity
;
Diffusion
;
Enterococcus faecalis
;
Ferula*
;
Fibroblasts
;
Plants*
;
Plants, Medicinal
;
Sodium Hypochlorite
;
Spectrum Analysis
;
Staphylococcus aureus
;
Streptococcus mitis